{"id":29365,"date":"2025-12-02T04:35:00","date_gmt":"2025-12-01T20:35:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=29365"},"modified":"2025-12-02T05:51:31","modified_gmt":"2025-12-01T21:51:31","slug":"jama-intern-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%85%a2%e8%8a%82%e5%a5%8f%e9%9f%b3%e4%b9%90%e4%b8%8e%e6%8e%a5%e5%8f%97%e6%9c%ba%e6%a2%b0%e9%80%9a%e6%b0%94%e8%80%81%e5%b9%b4%e6%82%a3","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=29365","title":{"rendered":"[JAMA Intern Med\u53d1\u8868\u8bba\u6587]\uff1a\u6162\u8282\u594f\u97f3\u4e50\u4e0e\u63a5\u53d7\u673a\u68b0\u901a\u6c14\u8001\u5e74\u60a3\u8005\u7684\u65e0\u8c35\u5984\/\u660f\u8ff7\u5929\u6570"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

Aging and Health<\/p>\n\n\n\n

Slow-Tempo Music and Delirium\/Coma-Free Days Among Older Adults Undergoing Mechanical Ventilation: A Randomized Clinical Trial<\/h1>\n\n\n\n

Babar A. Khan, Sikandar H. Khan, Anthony J. Perkins, et al<\/h3>\n\n\n\n

JAMA Intern Med Published Online: October 13, 2025<\/h3>\n\n\n\n

doi: 10.1001\/jamainternmed.2025.5263<\/h3>\n\n\n\n

Key Points<\/p>\n\n\n\n

Question<\/strong>  Among critically ill, mechanically ventilated older adults in the intensive care unit, does a music-listening intervention reduce delirium, pain, or anxiety?<\/p>\n\n\n\n

Findings<\/strong>  In this randomized clinical trial of 158 mechanically ventilated older adults, a twice-daily music intervention delivered via noise-canceling headphones and tablets for up to 7 days did not demonstrate a statistically significant decrease in delirium duration, delirium severity, pain, or anxiety.<\/p>\n\n\n\n

Meaning<\/strong>  A music-listening intervention did not improve delirium, pain, or anxiety among critically ill older adults.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  An estimated 70% to 80% of older adults develop delirium in the intensive care unit (ICU).<\/p>\n\n\n\n

Objective<\/strong>  To determine if a slow-tempo music (60-80 beats\/min) listening intervention decreases delirium duration, delirium severity, pain, or anxiety in older adults undergoing mechanical ventilation.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  This multicenter randomized clinical trial with concealed outcomes assessments was conducted in older adults undergoing mechanical ventilation from February 2020 to December 2023. Patients were enrolled from the ICUs of 2 hospitals affiliated with the Indiana University School of Medicine and from the Mayo Clinic in Rochester, Minnesota.<\/p>\n\n\n\n

Intervention<\/strong>  A music intervention comprising classical and contemporary tracks, delivered twice daily through noise-canceling headphones and tablets for up to 7 days, was compared to active control listening to a silence track delivered under identical conditions.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was delirium\/coma-free days during the 7-day intervention period assessed by the Confusion Assessment Method for the ICU (CAM-ICU) and the Richmond Agitation-Sedation Scale. The secondary outcomes were delirium severity assessed by the CAM-ICU-7, pain assessed by the Critical Care Pain Observation Tool, and anxiety assessed by the visual analog scale for anxiety (VAS-A).<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0A total of 158 patients were randomized (mean [SD] age, 68 (9.2) years; 72 [45.5%] female and 86 [54.4%] male). In an intention-to-treat analysis, no differences were found in the number of delirium\/coma-free days in the music intervention group compared with control (median [IQR] days, 2.5 [0-5] vs 3 [0-5];\u00a0P<\/em>\u2009=\u2009.66). There were also no statistically significant differences in the mean CAM-ICU-7 scores, mean pain scores, or mean VAS-A scores over the 7-day intervention period. By end of the 7-day period, both music intervention and control groups had similar mean (SD) CAM-ICU-7 scores (2.72 [2.80] vs 2.56 [2.72]), Critical Care Pain Observation Tool scores (0.20 [0.55] vs 0.61 [1.29]), and VAS-A scores (43.6 [24.7] vs 28.8 [38.4]).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  In this randomized clinical trial among older adults undergoing mechanical ventilation, a slow-tempo music intervention did not demonstrate a statistically significant decrease in delirium duration, delirium severity, pain, or anxiety symptoms.<\/p>\n\n\n\n

Trial Registration<\/strong>  ClinicalTrials.gov Identifier: NCT04182334<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  Aging and Health Slow-Temp […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29365"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29365"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29365\/revisions"}],"predecessor-version":[{"id":29672,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29365\/revisions\/29672"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}