{"id":29313,"date":"2025-11-25T04:24:00","date_gmt":"2025-11-24T20:24:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=29313"},"modified":"2025-11-25T05:33:38","modified_gmt":"2025-11-24T21:33:38","slug":"nejm%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a2024-2025%e5%b9%b4%e7%be%8e%e5%9b%bd%e9%80%80%e4%bc%8d%e5%86%9b%e4%ba%ba%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e7%96%ab%e8%8b%97%e6%8e%a5%e7%a7%8d","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=29313","title":{"rendered":"[NEJM\u53d1\u8868\u8bba\u6587]\uff1a2024-2025\u5e74\u7f8e\u56fd\u9000\u4f0d\u519b\u4eba\u65b0\u51a0\u75c5\u6bd2\u75ab\u82d7\u63a5\u79cd\u4e0e\u4e34\u5e8a\u7ed3\u5c40\u7684\u76f8\u5173\u6027"},"content":{"rendered":"\n

ORIGINAL ARTICLE<\/a><\/p>\n\n\n\n

Association of 2024\u20132025 Covid-19 Vaccine with Covid-19 Outcomes in U.S. Veterans<\/h1>\n\n\n\n

Miao\u00a0Cai,\u00a0Yan\u00a0Xie,\u00a0Ziyad\u00a0Al-Aly<\/h3>\n\n\n\n

N Engl J Med Published\u00a0October 8, 2025<\/h3>\n\n\n\n

DOI: 10.1056\/NEJMoa2510226<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

BACKGROUND<\/h3>\n\n\n\n

Amid the declining clinical severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and diminishing public uptake of annual coronavirus disease 2019 (Covid-19) vaccines, contemporary evidence on vaccine effectiveness against clinically relevant outcomes is needed.<\/p>\n\n\n\n

METHODS<\/h3>\n\n\n\n

We conducted an observational study that used the electronic health records of the Department of Veterans Affairs to evaluate the effectiveness of the 2024\u20132025 Covid-19 vaccine among veterans who received the Covid-19 and influenza vaccines on the same day (164,132 participants) and in an active-comparator group of veterans who received the influenza vaccine only (131,839 participants), between September 3 and December 31, 2024. Participants were followed for 180 days or until the occurrence of an outcome, whichever came first. We used inverse-probability\u2013weighted models to estimate vaccine effectiveness (calculated as 1 minus the risk ratio) against Covid-19\u2013associated emergency department visits, hospitalizations, and deaths at 6 months.<\/p>\n\n\n\n

RESULTS<\/h3>\n\n\n\n

At 6 months of follow-up, the estimated vaccine effectiveness was 29.3% (95% confidence interval [CI], 19.1 to 39.2) against Covid-19\u2013associated emergency department visits (risk difference per 10,000 persons, 18.3; 95% CI, 10.8 to 27.6), 39.2% (95% CI, 21.6 to 54.5) against Covid-19\u2013associated hospitalizations (risk difference per 10,000 persons, 7.5; 95% CI, 3.4 to 13.0), and 64.0% (95% CI, 23.0 to 85.8) against Covid-19\u2013associated deaths (risk difference per 10,000 persons, 2.2; 95% CI, 0.5 to 6.9). Vaccine effectiveness against a composite of these outcomes was 28.3% (95% CI, 18.2 to 38.2), with a risk difference per 10,000 persons of 18.2 (95% CI, 10.7 to 27.5). The Covid-19 vaccine was associated with decreased risks of these outcomes across prespecified subgroups defined according to age (<65 years, 65 to 75 years, and >75 years), the presence or absence of major coexisting conditions, and immunocompetence status.<\/p>\n\n\n\n

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CONCLUSIONS<\/h3>\n\n\n\n

In this national cohort of U.S. veterans, the receipt of the 2024\u20132025 Covid-19 vaccine was associated with decreased risks of severe clinical outcomes. (Funded by the Department of Veterans Affairs.)<\/p>\n","protected":false},"excerpt":{"rendered":"

ORIGINAL ARTICLE Association of 2024\u20132025 Covid-19 Vacc […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29313"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29313"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29313\/revisions"}],"predecessor-version":[{"id":29314,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29313\/revisions\/29314"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}