Methods<\/h3>\n\n\n\n
We did a retrospective, nationwide, patient-level analysis of the Kids\u2019 Inpatient Database, including 5733 patients with acute pulmonary embolism<\/a> aged 0\u201319 years admitted to hospital in the USA in 2016 and 2019. The database includes data of all children admitted to hospital during the 2 years available. We also accessed the US Multiple Cause of Death database and population data from the US Census Bureau for the same 2 years. We estimated the incidence, mortality, case fatality<\/a>, and proportional mortality rates<\/a>, provided data on the annual pulmonary embolism burden, and provided data on clinical events recorded during hospitalisation.<\/p>\n\n\n\n In the years 2016 and 2019, 5733 patients (3353 [58.5%] female and 2380 [41.5%] male) were admitted to hospital with acute pulmonary embolism as the primary diagnosis or a concomitant diagnosis. The annual incidence of acute pulmonary embolism was 3\u00b75 (95% CI 3\u00b74\u20133\u00b76) per 100 000 people. Two peaks in the incidence rate were observed\u2014one in infants younger than 1 year and one in adolescents aged 15\u201319 years. The in-hospital\u00a0case fatality<\/a>\u00a0rate was 4\u00b75% (4\u00b70\u20135\u00b71). The crude odds ratio for in-hospital death among patients with (vs<\/em>\u00a0without) acute pulmonary embolism was 9\u00b73 (7\u00b79\u201310\u00b79). The association between acute pulmonary embolism and death persisted across different multivariable models. Patients with acute pulmonary embolism with high-risk (vs<\/em>\u00a0no high-risk) features had the highest risk of death: 25\u00b73% (20\u00b76\u201330\u00b75) among patients aged 0\u20139 years and 13\u00b79% (11\u00b79\u201316\u00b72) among patients aged 10\u201319 years. In patients without high-risk features, risk of death was 4\u00b79% (3\u00b71\u20137\u00b76) among patients aged 0\u20139 years and 0\u00b77% (0\u00b75\u20131\u00b70) among patients aged 10\u201319 years. The risk of\u00a0intracranial bleeding<\/a>\u00a0was also highest in the presence of pulmonary embolism with high-risk features: 8\u00b71% (5\u00b75\u201311\u00b77) among patients aged 0\u20139 years and 3\u00b76% (2\u00b76\u20134\u00b79) among patients aged 10\u201319 years. In patients without high-risk features, the risk of\u00a0intracranial bleeding<\/a>\u00a0was 2\u00b75% (1\u00b73\u20134\u00b76) among those aged 0\u20139 years and 0\u00b75% (0\u00b73\u20130\u00b78) in those aged 10\u201319 years. Reperfusion treatments beyond systemic\u00a0thrombolysis<\/a>\u00a0were rarely used among children and adolescents with acute pulmonary embolism.<\/p>\n\n\n\n Acute pulmonary embolism is rare during childhood and adolescence. The high pulmonary embolism-related fatality among specific subgroups of patients can be interpreted in the context of severe comorbidities and pulmonary embolism events with high-risk features.<\/p>\n\n\n\n None.<\/p>\n","protected":false},"excerpt":{"rendered":" Articles Acute pulmonary embolism in children and adole […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29273"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=29273"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29273\/revisions"}],"predecessor-version":[{"id":29274,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/29273\/revisions\/29274"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=29273"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=29273"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=29273"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Findings<\/h3>\n\n\n\n
![\"\"\/](\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S2213260024004120-gr1_lrg.jpg\")
<\/figure>\n\n\n\n![\"\"\/](\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S2213260024004120-gr2_lrg.jpg\")
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<\/figure>\n\n\n\nInterpretation<\/h3>\n\n\n\n
Funding<\/h3>\n\n\n\n