{"id":28983,"date":"2025-10-01T04:11:00","date_gmt":"2025-09-30T20:11:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=28983"},"modified":"2025-10-01T05:44:42","modified_gmt":"2025-09-30T21:44:42","slug":"jama%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e7%be%8e%e5%9b%bd%e5%9b%bd%e7%ab%8b%e5%8d%ab%e7%94%9f%e7%a0%94%e7%a9%b6%e9%99%a2%e7%bb%88%e6%ad%a2%e7%9a%84%e7%a0%94%e7%a9%b6%e9%a1%b9%e7%9b%ae","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=28983","title":{"rendered":"[JAMA\u53d1\u8868\u8bba\u6587]\uff1a\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7ec8\u6b62\u7684\u7814\u7a76\u9879\u76ee\u7279\u5f81"},"content":{"rendered":"\n

Research Letter <\/p>\n\n\n\n

Characterization of Research Grant Terminations at the National Institutes of Health<\/h1>\n\n\n\n

Michael Liu, Kushal T. Kadakia, Vishal R. Patel, et al<\/h3>\n\n\n\n

JAMA 2025;334;(6):534-536. doi:10.1001\/jama.2025.7707<\/h3>\n\n\n\n

The National Institutes of Health (NIH) recently initiated a series of grant terminations focused on topics not aligned with agency priorities.1<\/a><\/sup> The scope of terminations, types of grants affected, and differential impact of cuts across career stages have not been characterized, resulting in uncertainty about the implications of grant terminations on the US health research enterprise.2<\/a><\/sup>,3<\/a><\/sup> Therefore, this study quantified the number and corresponding funding amounts of terminated NIH grants overall and by institute or center and award type.<\/a><\/p>\n\n\n\n

Methods<\/a><\/p>\n\n\n\n

We used the Tracking Accountability in Government Grants System database to identify all grants awarded by the US Department of Health and Human Services that were terminated since the start of the current presidential administration.4<\/a><\/sup> Only grants where the NIH was listed as the awarding office were analyzed. The activity code and administering institute or center were derived from the Federal Award Identification Number. Grants were categorized as research project grants, early career grants, center grants, or other grants based on their activity codes per NIH definitions.5<\/a><\/sup> The number of terminated grants, obligated funding dollars, and unexpended funding dollars were summed across administering institutes and centers and award types. Proportions of terminated grants and funding dollars across all previously active grants were calculated. To evaluate the relative size of terminated grants, we calculated the ratio of the proportion of terminated funding dollars to the proportion of terminated grants across institutes and centers. The RePORTER tool\u2014a repository of all NIH funding\u2014was used to determine total grant and funding denominators of active projects before grant terminations. Data were obtained on April 25, 2025, and analyses were performed using R version 4.4.3 (R Foundation).<\/a><\/p>\n\n\n\n

Results<\/a><\/p>\n\n\n\n

Between February 28, 2025, and April 8, 2025, 694 NIH grants were terminated across 24 of the 26 institutes and centers (including the Office of the Director) that administered active NIH grants. No grants administered by the NIH Clinical Center or the National Center for Complementary and Integrative Health were terminated. The cumulative amount of terminated grant funding was $1.81 billion, of which $544\u202f024\u202f077 (30.0%) had not been expended at the time of grant termination. Across 210 recipient institutions, Columbia University (n\u2009=\u2009157), Johns Hopkins University (n\u2009=\u200919), Yale University (n\u2009=\u200914), Emory University (n\u2009=\u200914), University of Michigan (n\u2009=\u200914), Northwestern University (n\u2009=\u200913), University of California San Francisco (n\u2009=\u200913), University of Miami (n\u2009=\u200912), University of Pittsburgh (n\u2009=\u200910), and University of Maryland (n\u2009=\u200910) experienced the highest number of grant terminations.<\/a><\/p>\n\n\n\n

The largest number of terminated grants was administered by the National Institute of Mental Health (n\u2009=\u2009128) and the National Institute on Minority Health and Health Disparities (NIMHD; n\u2009=\u200977) (Table 1<\/a>). The dollar amount of terminated grant funding was highest for the National Institute of Allergy and Infectious Diseases ($505\u202f968\u202f126) and the NIMHD ($223\u202f566\u202f041). Across all institutes and centers, the NIMHD accounted for the greatest proportion of terminated grants relative to previously active grants (77\/864 [8.9%]) and the highest proportion of terminated funding relative to previously active funding ($223\u202f566\u202f041\/$755\u202f275\u202f779 [29.6%]). The ratio of the proportion of terminated funding to the proportion of terminated grants across institutes and centers ranged from 0.5 to 11.9.<\/a><\/p>\n\n\n\n

Table 1. \u00a0Terminated National Institutes of Health Grants by Institute or Center<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
Institute\/center<\/th>No.\/total No. (%)<\/th>Amount of terminated grants\/total amount of all grants, $ (%)<\/th>Ratioa<\/sup><\/th>Unexpended amount of terminated grants, $<\/th><\/tr><\/thead>
National Institute on Minority Health and Health Disparities<\/td>77\/864 (8.9)<\/td>223\u202f566\u202f041\/755\u202f275\u202f779 (29.6)<\/td>3.3<\/td>66\u202f579\u202f646<\/td><\/tr>
National Institute of Nursing Research<\/td>19\/379 (5.0)<\/td>30\u202f201\u202f265\/225\u202f701\u202f215 (13.4)<\/td>2.7<\/td>12\u202f546\u202f431<\/td><\/tr>
Fogarty International Center<\/td>12\/483 (2.5)<\/td>12\u202f902\u202f867\/123\u202f792\u202f439 (10.4)<\/td>4.2<\/td>4\u202f566\u202f308<\/td><\/tr>
National Center for Advancing Translational Sciences<\/td>3\/549 (0.5)<\/td>57\u202f155\u202f428\/882\u202f130\u202f169 (6.5)<\/td>11.9<\/td>6\u202f373\u202f432<\/td><\/tr>
National Institute on Alcohol Abuse and Alcoholism<\/td>34\/1179 (2.9)<\/td>34\u202f197\u202f017\/539\u202f813\u202f462 (6.3)<\/td>2.2<\/td>10\u202f066\u202f941<\/td><\/tr>
National Institute of Mental Health<\/td>128\/4324 (3.0)<\/td>172\u202f818\u202f996\/2\u202f728\u202f706\u202f641 (6.3)<\/td>2.1<\/td>47\u202f004\u202f871<\/td><\/tr>
National Institute of Allergy and Infectious Diseases<\/td>59\/8560 (0.7)<\/td>505\u202f968\u202f126\/8\u202f172\u202f186\u202f424 (6.2)<\/td>9.0<\/td>112\u202f876\u202f236<\/td><\/tr>
National Institute of Child Health and Human Development<\/td>59\/3861 (1.5)<\/td>124\u202f301\u202f573\/2\u202f150\u202f408\u202f225 (5.8)<\/td>3.8<\/td>47\u202f091\u202f699<\/td><\/tr>
National Institute on Drug Abuse<\/td>45\/3118 (1.4)<\/td>97\u202f414\u202f919\/2\u202f276\u202f938\u202f853 (4.3)<\/td>3.0<\/td>24\u202f219\u202f110<\/td><\/tr>
National Institute on Aging<\/td>36\/6421 (0.6)<\/td>127\u202f510\u202f085\/5\u202f337\u202f581\u202f099 (2.4)<\/td>4.3<\/td>49\u202f121\u202f478<\/td><\/tr>
National Cancer Institute<\/td>59\/10\u202f694 (0.6)<\/td>180\u202f774\u202f481\/7\u202f988\u202f134\u202f520 (2.3)<\/td>4.1<\/td>91\u202f059\u202f461<\/td><\/tr>
Office of the Director<\/td>40\/908 (4.4)<\/td>43\u202f219\u202f562\/1\u202f942\u202f042\u202f766 (2.2)<\/td>0.5<\/td>17\u202f185\u202f163<\/td><\/tr>
National Institute of Arthritis and Musculoskeletal and Skin Diseases<\/td>6\/1789 (0.3)<\/td>17\u202f001\u202f440\/865\u202f011\u202f402 (2.0)<\/td>5.9<\/td>2\u202f777\u202f553<\/td><\/tr>
National Human Genome Research Institute<\/td>7\/835 (0.8)<\/td>11\u202f970\u202f833\/680\u202f067\u202f549 (1.8)<\/td>2.1<\/td>4\u202f710\u202f440<\/td><\/tr>
National Institute of Environmental Health Sciences<\/td>16\/1444 (1.1)<\/td>15\u202f322\u202f668\/945\u202f481\u202f114 (1.6)<\/td>1.5<\/td>4\u202f279\u202f578<\/td><\/tr>
National Library of Medicine<\/td>5\/276 (1.8)<\/td>8\u202f421\u202f529\/523\u202f351\u202f050 (1.6)<\/td>0.9<\/td>586\u202f661<\/td><\/tr>
National Institute of General Medical Sciences<\/td>26\/7933 (0.3)<\/td>55\u202f068\u202f031\/3\u202f450\u202f717\u202f898 (1.6)<\/td>4.9<\/td>12\u202f667\u202f916<\/td><\/tr>
National Institute of Neurological Disorders and Stroke<\/td>12\/5678 (0.2)<\/td>37\u202f225\u202f669\/3\u202f711\u202f124\u202f978 (1.0)<\/td>4.7<\/td>14\u202f187\u202f821<\/td><\/tr>
National Institute of Diabetes and Digestive and Kidney Diseases<\/td>14\/4889 (0.3)<\/td>16\u202f973\u202f836\/2\u202f456\u202f788\u202f467 (0.7)<\/td>2.4<\/td>3\u202f340\u202f237<\/td><\/tr>
National Institute of Dental and Craniofacial Research<\/td>5\/1396 (0.4)<\/td>3\u202f761\u202f325\/596\u202f001\u202f809 (0.6)<\/td>1.8<\/td>1\u202f121\u202f496<\/td><\/tr>
National Eye Institute<\/td>6\/2093 (0.3)<\/td>5\u202f817\u202f956\/966\u202f303\u202f208 (0.6)<\/td>2.1<\/td>1\u202f075\u202f619<\/td><\/tr>
National Heart, Lung, and Blood Institute<\/td>19\/7205 (0.3)<\/td>28\u202f059\u202f366\/5\u202f750\u202f114\u202f380 (0.5)<\/td>1.9<\/td>9\u202f078\u202f625<\/td><\/tr>
National Institute on Deafness and Other Communication Disorders<\/td>4\/1231 (0.3)<\/td>2\u202f667\u202f864\/591\u202f012\u202f441 (0.5)<\/td>1.4<\/td>1\u202f332\u202f510<\/td><\/tr>
National Institute of Biomedical Imaging and Bioengineering<\/td>3\/1115 (0.3)<\/td>860\u202f033\/579\u202f549\u202f188 (0.1)<\/td>0.6<\/td>174\u202f845<\/td><\/tr>
Total<\/td>694\/77\u202f174 (0.9)<\/td>1\u202f813\u202f180\u202f909\/54\u202f238\u202f235\u202f075 (3.3)<\/td>3.7<\/td>544\u202f024\u202f077<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Across 694 terminated grants, 400 (57.6%) were research project grants, 139 (20.0%) were early career grants, 111 (16.0%) were other grants, and 44 (6.3%) were center grants (Table 2<\/a>). Within award types, the dollar amount of terminated grant funding was largest among R01 grants (n\u2009=\u2009229; $470\u202f994\u202f788), followed by U54 grants (n\u2009=\u200931; $211\u202f796\u202f665), T32 grants (n\u2009=\u200927; $44\u202f947\u202f561), and OT2 grants (n\u2009=\u200936; $37\u202f188\u202f312).<\/a><\/p>\n\n\n\n

Table 2. \u00a0Terminated National Institutes of Health (NIH) Grants by Award Type<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
Award type<\/th>Terminated grants, No.<\/th>Total amount of terminated grants, $<\/th>Unexpended amount of terminated grants, $<\/th><\/tr><\/thead>
Research project grants<\/td><\/tr>
Total<\/td>400<\/td>1\u202f207\u202f493\u202f474<\/td>344\u202f710\u202f407<\/td><\/tr>
R01<\/td>229<\/td>470\u202f994\u202f788<\/td>139\u202f967\u202f006<\/td><\/tr>
UM1<\/td>5<\/td>218\u202f479\u202f211<\/td>26\u202f259\u202f747<\/td><\/tr>
U19<\/td>4<\/td>208\u202f820\u202f072<\/td>85\u202f296\u202f548<\/td><\/tr>
U01<\/td>22<\/td>115\u202f501\u202f301<\/td>19\u202f305\u202f292<\/td><\/tr>
UM2<\/td>2<\/td>60\u202f620\u202f049<\/td>25\u202f226\u202f806<\/td><\/tr>
Early career grants<\/td><\/tr>
Total<\/td>139<\/td>85\u202f601\u202f357<\/td>17\u202f182\u202f577<\/td><\/tr>
T32<\/td>27<\/td>44\u202f947\u202f561<\/td>8\u202f352\u202f796<\/td><\/tr>
K12<\/td>5<\/td>14\u202f636\u202f579<\/td>3\u202f366\u202f803<\/td><\/tr>
K01<\/td>12<\/td>7\u202f053\u202f456<\/td>1\u202f002\u202f995<\/td><\/tr>
K23<\/td>10<\/td>4\u202f811\u202f223<\/td>1\u202f257\u202f489<\/td><\/tr>
F31<\/td>59<\/td>4\u202f440\u202f069<\/td>986\u202f561<\/td><\/tr>
Center grants<\/td><\/tr>
Total<\/td>44<\/td>363\u202f590\u202f903<\/td>135\u202f139\u202f952<\/td><\/tr>
U54<\/td>31<\/td>211\u202f796\u202f665<\/td>106\u202f863\u202f380<\/td><\/tr>
P30<\/td>5<\/td>60\u202f953\u202f579<\/td>7\u202f031\u202f361<\/td><\/tr>
P50<\/td>5<\/td>45\u202f755\u202f805<\/td>14\u202f198\u202f730<\/td><\/tr>
UL1<\/td>1<\/td>42\u202f625\u202f469<\/td>4\u202f748\u202f175<\/td><\/tr>
P20<\/td>2<\/td>2\u202f459\u202f384<\/td>2\u202f298\u202f306<\/td><\/tr>
Other grants<\/td><\/tr>
Total<\/td>111<\/td>156\u202f495\u202f176<\/td>46\u202f991\u202f141<\/td><\/tr>
OT2<\/td>36<\/td>37\u202f188\u202f312<\/td>13\u202f179\u202f277<\/td><\/tr>
U24<\/td>4<\/td>26\u202f054\u202f874<\/td>7\u202f299\u202f611<\/td><\/tr>
R25<\/td>28<\/td>23\u202f942\u202f617<\/td>6\u202f568\u202f332<\/td><\/tr>
R24<\/td>5<\/td>15\u202f880\u202f965<\/td>6\u202f346\u202f934<\/td><\/tr>
S06<\/td>2<\/td>12\u202f896\u202f676<\/td>3\u202f583\u202f820<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Discussion<\/a><\/p>\n\n\n\n

Targeted grant terminations have affected more than $1.8 billion in NIH funding. Terminations were spread across nearly all NIH institutes and centers, although cuts disproportionately impacted the NIMHD (30% of all funding).<\/a><\/p>\n\n\n\n

The proportion of terminated grant funding was higher than the proportion of grants terminated across most institutes and centers, suggesting that larger-than-average grants were more likely to be terminated. Although most terminated grants were classified as independent research projects, 20% were formal training, fellowship, or career development awards.6<\/a><\/sup> Study findings also demonstrate that grant terminations have affected both public and private recipient institutions across the US.<\/a><\/p>\n\n\n\n

Study limitations include an inability to systematically categorize topic areas of terminated grants and lack of data on the specific reasons for grant terminations.<\/a><\/p>\n\n\n\n

The landscape of NIH grant terminations continues to evolve dynamically. Ongoing monitoring and data transparency will be critical for understanding the impact of grant terminations on the US health research enterprise.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research Letter  Characterization of Research Gran […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28983"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28983"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28983\/revisions"}],"predecessor-version":[{"id":29230,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28983\/revisions\/29230"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28983"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28983"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}