{"id":28383,"date":"2025-07-12T04:15:00","date_gmt":"2025-07-11T20:15:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=28383"},"modified":"2025-07-12T06:23:48","modified_gmt":"2025-07-11T22:23:48","slug":"jama-intern-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e9%bb%84%e6%b2%b9%e5%92%8c%e6%a4%8d%e7%89%a9%e6%b2%b9%e7%9a%84%e6%91%84%e5%85%a5%e9%87%8f%e4%b8%8e%e6%ad%bb%e4%ba%a1%e7%8e%87","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=28383","title":{"rendered":"[JAMA Intern Med\u53d1\u8868\u8bba\u6587]\uff1a\u9ec4\u6cb9\u548c\u690d\u7269\u6cb9\u7684\u6444\u5165\u91cf\u4e0e\u6b7b\u4ea1\u7387"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

March 6, 2025<\/p>\n\n\n\n

Butter and Plant-Based Oils Intake and Mortality<\/h1>\n\n\n\n

Yu Zhang, Katia S. Chadaideh, Yanping Li, et al<\/h3>\n\n\n\n

JAMA Intern Med. <\/em>2025;185(5):549-560. doi:10.1001\/jamainternmed.2025.0205<\/h3>\n\n\n\n

<\/a>Key Points<\/p>\n\n\n\n

Question<\/strong>  What are the associations of long-term intakes of butter and plant-based oils with mortality in the US population?<\/p>\n\n\n\n

Findings<\/strong>  In this cohort study of 221\u202f054 adults from 3 large cohorts, higher butter intake was associated with increased total and cancer mortality, while higher intake of plant-based oils was associated with lower total, cancer, and cardiovascular disease mortality.<\/p>\n\n\n\n

Meaning<\/strong>  Substituting butter with plant-based oils, particularly olive, soybean, and canola oils, may confer substantial benefits for preventing premature deaths.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  The relationship between butter and plant-based oil intakes and mortality remains unclear, with conflicting results from previous studies. Long-term dietary assessments are needed to clarify these associations.<\/p>\n\n\n\n

Objective<\/strong>  To investigate associations of butter and plant-based oil intakes with risk of total and cause-specific mortality among US adults.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  This prospective population-based cohort study used data from 3 large cohorts: the Nurses\u2019 Health Study (1990-2023), the Nurses\u2019 Health Study II (1991-2023), and the Health Professionals Follow-up Study (1990-2023). Women and men who were free of cancer, cardiovascular disease (CVD), diabetes, or neurodegenerative disease at baseline were included.<\/p>\n\n\n\n

Exposures<\/strong>  Primary exposures included intakes of butter (butter added at the table and from cooking) and plant-based oil (safflower, soybean, corn, canola, and olive oil). Diet was assessed by validated semiquantitative food frequency questionnaires every 4 years.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  Total mortality was the primary outcome, and mortality due to cancer and CVD were secondary outcomes. Deaths were identified through the National Death Index and other sources. A physician classified the cause of death based on death certificates and medical records.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0During up to 33 years of follow-up among 221\u202f054 adults (mean [SD] age at baseline: 56.1 [7.1] years for Nurses\u2019 Health Study, 36.1 [4.7] years for Nurses\u2019 Health Study II, and 56.3 [9.3] years for Health Professionals Follow-up Study), 50\u202f932 deaths were documented, with 12\u202f241 due to cancer and 11\u202f240 due to CVD. Participants were categorized into quartiles based on their butter or plant-based oil intake. After adjusting for potential confounders, the highest butter intake was associated with a 15% higher risk of total mortality compared to the lowest intake (hazard ratio [HR], 1.15; 95% CI, 1.08-1.22;\u00a0P\u00a0<\/em>for trend\u2009<\u2009.001). In contrast, the highest intake of total plant-based oils compared to the lowest intake was associated with a 16% lower total mortality (HR, 0.84; 95% CI, 0.79-0.90;\u00a0P<\/em>\u00a0for trend\u2009<\u2009.001). There was a statistically significant association between higher intakes of canola, soybean, and olive oils and lower total mortality, with HRs per 5-g\/d increment of 0.85 (95% CI, 0.78-0.92), 0.94 (95% CI, 0.91-0.96), and 0.92 (95% CI, 0.91-0.94), respectively (all\u00a0P\u00a0<\/em>for trend\u2009<\u2009.001). Every 10-g\/d increment in plant-based oils intake was associated with an 11% lower risk of cancer mortality (HR, 0.89; 95% CI, 0.85-0.94;\u00a0P\u00a0<\/em>for trend\u2009<\u2009.001) and a 6% lower risk of CVD mortality (HR, 0.94; 95% CI, 0.89-0.99;\u00a0P\u00a0<\/em>for trend\u2009=\u2009.03), whereas a higher intake of butter was associated with higher cancer mortality (HR, 1.12; 95% CI, 1.04-1.20;\u00a0P<\/em>\u00a0for trend\u2009<\u2009.001). Substituting 10-g\/d intake of total butter with an equivalent amount of total plant-based oils was associated with an estimated 17% reduction in total mortality (HR, 0.83; 95% CI, 0.79-0.86;\u00a0P<\/em>\u2009<\u2009.001) and a 17% reduction in cancer mortality (HR, 0.83; 95% CI, 0.76-0.90;\u00a0P<\/em>\u2009<\u2009.001).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  In this cohort study, higher intake of butter was associated with increased mortality, while higher plant-based oils intake was associated with lower mortality. Substituting butter with plant-based oils may confer substantial benefits for preventing premature deaths.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  March 6, 2025 Butter and P […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28383"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28383"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28383\/revisions"}],"predecessor-version":[{"id":28697,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28383\/revisions\/28697"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}