{"id":28316,"date":"2025-07-02T04:16:00","date_gmt":"2025-07-01T20:16:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=28316"},"modified":"2025-07-02T05:49:01","modified_gmt":"2025-07-01T21:49:01","slug":"jama-netw-open%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%a4%96%e5%91%a8%e9%9d%99%e8%84%89%e5%af%bc%e7%ae%a1%e7%95%99%e7%bd%ae%e6%97%b6%e9%97%b4%e4%b8%8e%e8%a1%80%e6%b5%81%e6%84%9f%e6%9f%93","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=28316","title":{"rendered":"[JAMA Netw Open\u53d1\u8868\u8bba\u6587]\uff1a\u5916\u5468\u9759\u8109\u5bfc\u7ba1\u7559\u7f6e\u65f6\u95f4\u4e0e\u8840\u6d41\u611f\u67d3\u98ce\u9669"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

Infectious Diseases<\/p>\n\n\n\n

April 24, 2025<\/p>\n\n\n\n

Dwell Time and Risk of Bloodstream Infection With Peripheral Intravenous Catheters<\/h1>\n\n\n\n

Marie-C\u00e9line Zanella, Gaud Catho, Holly Jackson, et al<\/h3>\n\n\n\n

JAMA Netw Open. <\/em>2025;8(4):e257202. doi:10.1001\/jamanetworkopen.2025.7202<\/h3>\n\n\n\n

<\/a>Key Points<\/p>\n\n\n\n

Question<\/strong>  What is the association of dwell time with the risk of bloodstream infections with peripheral intravenous catheters (PIVCs)?<\/p>\n\n\n\n

Findings<\/strong>  In this cohort study conducted at Geneva University Hospitals and including 371\u202f061 PIVCs, the risk of bloodstream infections was significantly increased after 3 days of dwell time.<\/p>\n\n\n\n

Meaning<\/strong>  This study suggests that the indication for PIVC should be challenged and PIVC replacement should be considered after 3 days of dwell time.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Bloodstream infections (BSIs) associated with peripheral intravenous catheters (PIVCs) are rare but preventable adverse events. The association of dwell time with the risk of BSIs with PIVCs remains controversial.<\/p>\n\n\n\n

Objective<\/strong>  To analyze the risk of BSIs during PIVC maintenance therapy.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  In this observational cohort study, all patients hospitalized at Geneva University Hospitals with at least 1 PIVC insertion on the upper extremity (N\u2009=\u2009371\u202f061) between January 1, 2016, and February 29, 2020, were evaluated. Statistical analysis was performed from January 2023 to January 2025.<\/p>\n\n\n\n

Exposure<\/strong>  At least 1 PIVC insertion on the upper extremity.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was BSIs with PIVCs; data were collected by prospective BSI surveillance. The daily risk of BSIs with PIVCs was analyzed using the hazard rate function by kernel-based methods. Multivariable logistic models were performed to evaluate the risk of BSIs with PIVCs comparing different cutoff values of dwell times (>3 vs \u22643 days, >4 vs \u22644 days, >5 vs \u22645 days, and >6 vs \u22646 days).<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0A total of 371\u202f061 PIVCs (median patient age, 63 years [IQR, 41-79 years]; 187\u202f786 women [51%]) with documented catheter duration were included. A total of 140\u202f178 PIVCs (38%) had a dwell time of 1 to 2 days, 119\u202f252 (32%) had a dwell time of 3 to 4 days, and 111\u202f631 (30%) had a dwell time of more than 4 days. The instantaneous risk of BSIs with PIVCs was low in the first 2 days of dwell time and increased rapidly thereafter. The risk of BSIs was significantly increased after 3 days of catheter maintenance (adjusted odds ratio [AOR], 13.55; 95% CI, 5.44-34.00). This risk was the highest after 3 days and remained increased thereafter (>4 days: AOR, 8.53; 95% CI, 4.47-16.28; >5 days: AOR, 5.38; 95% CI, 3.23-8.96; and >6 days: AOR, 7.63; 95% CI, 4.57-12.74).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  In this cohort study of 371\u202f061 PIVCs, dwell time was associated with the development of BSIs with PIVCs. After day 3, PIVC indication should be reviewed and PIVC replacement considered.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  Infectious Diseases April& […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28316"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28316"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28316\/revisions"}],"predecessor-version":[{"id":28684,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28316\/revisions\/28684"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28316"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28316"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}