{"id":28125,"date":"2025-05-31T04:17:00","date_gmt":"2025-05-30T20:17:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=28125"},"modified":"2025-05-31T07:07:16","modified_gmt":"2025-05-30T23:07:16","slug":"jama-netw-open%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%ae%9e%e7%94%a8%e6%80%a7%e8%b4%ab%e8%a1%80%e9%9b%86%e6%9d%9f%e5%8c%96%e6%8e%aa%e6%96%bd%e4%b8%8e%e9%87%8d%e7%97%87%e6%82%a3%e8%80%85","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=28125","title":{"rendered":"[JAMA Netw Open\u53d1\u8868\u8bba\u6587]\uff1a\u5b9e\u7528\u6027\u8d2b\u8840\u96c6\u675f\u5316\u63aa\u65bd\u4e0e\u91cd\u75c7\u60a3\u8005\u8840\u7ea2\u86cb\u767d\u6062\u590d"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

Critical Care Medicine<\/p>\n\n\n\n

March 28, 2025<\/p>\n\n\n\n

Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial<\/h1>\n\n\n\n

Matthew A. Warner, Matthew L. Johnson, Andrew C. Hanson, et al<\/h3>\n\n\n\n

JAMA Netw Open. <\/em>2025;8(3):e252353. doi:10.1001\/jamanetworkopen.2025.2353<\/h3>\n\n\n\n

<\/a>Key Points<\/p>\n\n\n\n

Question<\/strong>  Does a multifaceted anemia prevention and treatment bundle vs standard care improve hemoglobin recovery and functional outcomes in adults with postsurgical or medical critical illness?<\/p>\n\n\n\n

Findings<\/strong>  In this randomized clinical trial that included 100 critically ill adults, receipt of the anemia intervention bundle achieved significantly higher hemoglobin recovery up to 3 months after hospital discharge compared with standard care.<\/p>\n\n\n\n

Meaning<\/strong>  The findings of this trial indicate that using an anemia prevention and treatment bundle improves hemoglobin concentrations after acute illness; these data can inform the design of future trials.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Anemia is a common complication of surgery and acute illness that is associated with adverse clinical outcomes. The role of anemia prevention and treatment strategies in this setting remains unclear.<\/p>\n\n\n\n

Objective<\/strong>  To evaluate the effect of a multifaceted anemia management bundle vs standard care on posthospitalization hemoglobin recovery and multidimensional functional outcomes in survivors of acute illness.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  This parallel group randomized clinical trial, known as the Practical Anemia Bundle for Sustained Blood Recovery, was conducted at postsurgical and medical intensive care units at a large US medical center. Critically ill patients (aged \u226518 years) with moderate to severe anemia (hemoglobin concentration <10 g\/dL) were enrolled between March 2022 and November 2023. Participants were randomly assigned 1:1 to the intervention or standard care group. Intention-to-treat analyses were performed between July 2024 and January 2025.<\/p>\n\n\n\n

Intervention<\/strong>  The intervention bundle was delivered throughout the duration of hospitalization and included optimized phlebotomy practices, clinical decision support, and pharmacological anemia treatment with intravenous iron.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was the mean difference in hemoglobin concentration at 1 month after hospital discharge.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0A total of 100 patients (median [IQR] age, 68 [61-72] years; 57 men [57.0%]; 65 [65.0%] with postsurgical admission to the intensive care unit) were enrolled during acute illness. Forty-nine patients (49.0%) were assigned to receive the intervention, and 51 (51.0%) were assigned to receive standard care. Hemoglobin concentration at 1 month after discharge was greater in patients receiving the intervention vs standard care (median [IQR], 12.2 [11.8-13.0] g\/dL vs 11.5 [10.2-12.6] g\/dL; adjusted mean difference, 0.69 [95% CI, 0.13-1.20] g\/dL;\u00a0P<\/em>\u2009=\u2009.02).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  This randomized clinical trial found that a multifaceted anemia prevention and treatment bundle was feasible, was well tolerated, and improved posthospitalization hemoglobin concentrations up to 3 months in critically ill adults. These findings can inform the design of future trials.<\/p>\n\n\n\n

Trial Registration<\/strong>  ClinicalTrials.gov Identifier: NCT05167734<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  Critical Care Medicine Mar […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28125"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28125"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28125\/revisions"}],"predecessor-version":[{"id":28502,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/28125\/revisions\/28502"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=28125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=28125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}