{"id":27922,"date":"2025-06-10T04:21:00","date_gmt":"2025-06-09T20:21:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=27922"},"modified":"2025-06-10T06:00:14","modified_gmt":"2025-06-09T22:00:14","slug":"icu-management-practice-%e6%9c%af%e5%90%8e%e8%84%93%e6%af%92%e7%97%87%e5%af%b9%e7%97%b4%e5%91%86%e7%9a%84%e5%bd%b1%e5%93%8d","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=27922","title":{"rendered":"[ICU Management &#038; Practice]: \u672f\u540e\u8113\u6bd2\u75c7\u5bf9\u75f4\u5446\u7684\u5f71\u54cd"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Impact of Postoperative Sepsis on Dementia<\/h1>\n\n\n\n<ul>\n<li>In&nbsp;<a href=\"https:\/\/healthmanagement.org\/c\/sepsis\">Sepsis<\/a><\/li>\n\n\n\n<li>Mon, 10 Feb 2025<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/res.cloudinary.com\/healthmanagement-org\/image\/upload\/c_thumb,f_auto,fl_lossy,q_90\/v1739191415\/cw\/00129245_cw_image_wi_0f10e9f2e1a4777e693fb0da48db4f53.webp\" alt=\"\"\/><\/figure>\n\n\n\n<p>Dementia is a progressive neurodegenerative disease with growing public health and economic implications. In 2019, 57.4 million people had dementia worldwide, a number projected to reach 152.8 million by 2050. The global financial burden is substantial, estimated at $1.31 trillion annually. As dementia prevalence rises, increased healthcare resources and preventive strategies will be critical.<\/p>\n\n\n\n<p>Postoperative sepsis is a severe complication that increases morbidity, mortality, and the risk of long-term cognitive decline, including dementia. It triggers systemic inflammation, blood-brain barrier dysfunction, and neuronal damage. While sepsis has been linked to dementia in general populations, its impact in postoperative settings remains understudied.<\/p>\n\n\n\n<p>A new study used data from the National Health Insurance Research Database (NHIRD) to investigate the association between postoperative sepsis and dementia. Previous research has explored infection-related dementia risk but not specifically in the postoperative period. If a link is confirmed, targeted perioperative interventions could help mitigate both immediate complications and long-term dementia risk.<\/p>\n\n\n\n<p>The study analysed data from Taiwan\u2019s National Database (2005\u20132022). Surgeries performed between 2008 and 2013 were analysed to identify patients without prior dementia. A 12-month post-surgery period was used to track sepsis events and assess their impact on dementia risk. 778 patients were in the postoperative sepsis group and 3,112 in the non-sepsis group.&nbsp;<\/p>\n\n\n\n<p>Study findings show that dementia incidence was higher in the sepsis group (26% vs. 13.6%). A dose-response relationship was observed, as dementia rates increased from 24.5% with one sepsis event to 34.9% with multiple events. Mortality was also higher in the sepsis group (40.5% vs. 31.6%).<\/p>\n\n\n\n<p>This study provides new evidence linking postoperative sepsis to increased risks of dementia and mortality in surgical patients. Patients who developed postoperative sepsis had a higher incidence of dementia (26% vs. 13.6%), with a dose-response effect\u2014those experiencing multiple sepsis events faced a significantly greater risk (34.9%). These findings highlight the need for improved perioperative infection control strategies to prevent sepsis and its long-term cognitive consequences.<\/p>\n\n\n\n<p>Compared to previous research, which primarily examined general infections, this study is among the first to focus specifically on postoperative sepsis. It highlights distinct mechanisms, including systemic inflammation, blood-brain barrier dysfunction, and neurovascular damage, that may contribute to cognitive decline following sepsis.<\/p>\n\n\n\n<p>These findings establish a strong association between postoperative sepsis and increased dementia risk, showing a dose-dependent effect. Patients with multiple sepsis episodes faced a significantly higher dementia incidence. The study highlights the need for improved perioperative infection control and sepsis prevention to mitigate both immediate and long-term cognitive risks.<\/p>\n\n\n\n<p>Source:&nbsp;<a href=\"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/s13054-025-05276-z\" target=\"_blank\" rel=\"noreferrer noopener\">Critical Care<\/a><br \/>Image Credit: iStock&nbsp;<br \/>&nbsp;<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">References:<\/h4>\n\n\n\n<p>Sun M, Li F, Wang Y et al. (2025)&nbsp;<a href=\"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/s13054-025-05276-z\" target=\"_blank\" rel=\"noreferrer noopener\">Postoperative sepsis and its sequential impact on dementia<\/a>. Crit Care. 29, 66.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Impact of Postoperative Sepsis on Dementia Dementia is  [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[24,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27922"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27922"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27922\/revisions"}],"predecessor-version":[{"id":27923,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27922\/revisions\/27923"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27922"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27922"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27922"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}