{"id":27870,"date":"2025-05-01T04:26:00","date_gmt":"2025-04-30T20:26:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=27870"},"modified":"2025-05-01T06:23:52","modified_gmt":"2025-04-30T22:23:52","slug":"bmj%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e8%82%a5%e8%83%96%e6%82%a3%e8%80%85%e9%95%87%e9%9d%99%e7%8a%b6%e6%80%81%e4%b8%8b%e8%a1%8c%e8%83%83%e8%82%a0%e9%95%9c%e6%97%b6%e9%ab%98%e6%b5%81","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=27870","title":{"rendered":"[BMJ\u53d1\u8868\u8bba\u6587]\uff1a\u80a5\u80d6\u60a3\u8005\u9547\u9759\u72b6\u6001\u4e0b\u884c\u80c3\u80a0\u955c\u65f6\u9ad8\u6d41\u91cf\u9f3b\u5bfc\u7ba1\u6c27\u7597\u5bf9\u7f3a\u6c27\u53d1\u751f\u7387\u7684\u5f71\u54cd"},"content":{"rendered":"\n<p><strong>Research<\/strong><\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"page-title\">Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial<\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">Leilei Wang, Yuanyuan Zhang, Dan Han, et al<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><em>BMJ<\/em>\u00a02025;\u00a0388\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1136\/bmj-2024-080795\">https:\/\/doi.org\/10.1136\/bmj-2024-080795<\/a>\u00a0(Published 11 February 2025)Cite this as:\u00a0<em>BMJ<\/em>\u00a02025;388:e080795<\/h3>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p id=\"p-2\"><strong>Objective<\/strong>&nbsp;To determine whether high flow nasal cannula (HFNC) oxygenation can reduce the incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity.<\/p>\n\n\n\n<p id=\"p-3\"><strong>Design<\/strong>&nbsp;Multicentre, randomised, parallel group trial.<\/p>\n\n\n\n<p id=\"p-4\"><strong>Setting<\/strong>&nbsp;Three tertiary hospitals in Shanghai, China.<\/p>\n\n\n\n<p id=\"p-5\"><strong>Participants<\/strong>&nbsp;1000 adult patients with obesity (body mass index \u226528) who were scheduled for gastrointestinal endoscopy.<\/p>\n\n\n\n<p id=\"p-6\"><strong>Interventions<\/strong>&nbsp;Participants were randomly allocated to receive regular nasal cannula oxygenation or HFNC oxygenation during a sedated procedure with propofol and low dose sufentanil.<\/p>\n\n\n\n<p id=\"p-7\"><strong>Main outcome measures<\/strong>&nbsp;The primary outcome was the incidence of hypoxia (75%\u2264SpO<sub>2<\/sub>&lt;90% for &lt;60 s) during the procedure. Secondary outcomes included the incidences of subclinical respiratory depression (90%\u2264SpO<sub>2<\/sub>&lt;95% for any duration) and severe hypoxia (SpO<sub>2<\/sub>&lt;75% for any duration or 75%\u2264SPO<sub>2<\/sub>&lt;90% for &gt;60 s) during the procedure.<\/p>\n\n\n\n<p id=\"p-8\"><strong>Results<\/strong>\u00a0From 6 May 2021 to 26 May 2023, 984 patients (mean age 49.2 years; 36.9% (n=363) female) completed the study and were analysed. Compared with regular nasal cannula oxygenation, HFNC oxygenation reduced the incidence of hypoxia from 21.2% (103\/487) to 2.0% (10\/497) (difference \u221219.14, 95% confidence interval \u221223.09 to \u221215.36; P&lt;0.001), subclinical respiratory depression from 36.3% (177\/487) to 5.6% (28\/497) (difference \u221230.71, \u221235.40 to \u221225.92; P&lt;0.001), and severe hypoxia from 4.1% (20\/487) to 0% (0\/497) (difference \u22124.11%, \u22126.26 to \u22122.48; P&lt;0.001). Other sedation related adverse events did not differ between the two groups.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.bmj.com\/content\/bmj\/388\/bmj-2024-080795\/F1.large.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.bmj.com\/content\/bmj\/388\/bmj-2024-080795\/F2.large.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<p id=\"p-9\"><strong>Conclusions<\/strong>&nbsp;In patients with obesity, oxygenation via HFNC during sedated gastrointestinal endoscopy significantly reduced the incidences of hypoxia, subclinical respiratory depression, and severe hypoxia without increasing other adverse events.<\/p>\n\n\n\n<p id=\"p-10\"><strong>Trial registration<\/strong>&nbsp;ClinicalTrials.gov&nbsp;<a href=\"https:\/\/www.bmj.com\/lookup\/external-ref?link_type=CLINTRIALGOV&amp;access_num=NCT04500392&amp;atom=%2Fbmj%2F388%2Fbmj-2024-080795.atom\">NCT04500392<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Effect of high flow nasal cannula oxygenation  [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27870"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27870"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27870\/revisions"}],"predecessor-version":[{"id":27871,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27870\/revisions\/27871"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}