{"id":27829,"date":"2025-04-28T04:07:00","date_gmt":"2025-04-27T20:07:00","guid":{"rendered":"https:\/\/csccm.org.cn\/?p=27829"},"modified":"2025-04-28T06:02:02","modified_gmt":"2025-04-27T22:02:02","slug":"clin-infect-dis%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e7%b2%aa%e8%8f%8c%e7%a7%bb%e6%a4%8d%e9%a2%84%e9%98%b2%e5%a4%8d%e5%8f%91%e6%80%a7%e9%9a%be%e8%be%a8%e6%a2%ad%e7%8a%b6%e8%8a%bd%e5%ad%a2","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=27829","title":{"rendered":"[Clin Infect Dis\u53d1\u8868\u8bba\u6587]\uff1a\u7caa\u83cc\u79fb\u690d\u9884\u9632\u590d\u53d1\u6027\u96be\u8fa8\u68ad\u72b6\u82bd\u5b62\u6746\u83cc\u611f\u67d3\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027"},"content":{"rendered":"\n

A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficile<\/em> Infection<\/h1>\n\n\n\n

Dimitri M Drekonja, Aasma Shaukat, Yuan Huang, et al<\/h3>\n\n\n\n

Clinical Infectious Diseases<\/em>, Volume 80, Issue 1, 15 January 2025, Pages 52\u201360, https:\/\/doi.org\/10.1093\/cid\/ciae467<\/a><\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/p>\n\n\n\n

Clostridioides difficile<\/em> infection (CDI) is the most common cause of healthcare\u2013associated infections in US hospitals, with 15%\u201330% of patients experiencing recurrence. The aim of our randomized, double-blind clinical trial was to assess the efficacy of capsule-delivered fecal microbiota transplant (FMT) versus placebo in reducing recurrent diarrhea and CDI recurrence. The secondary aim was FMT safety assessment.<\/p>\n\n\n\n

Methods<\/p>\n\n\n\n

Between 2018 and 2022, Veterans across the Veterans Health Administration system with recurrent CDI who responded to antibiotic treatment were randomized in a 1:1 ratio to oral FMT or placebo capsules. Randomization was stratified by number of prior CDI recurrences (1 or \u22652). The primary endpoint was clinical recurrence by day 56, defined as >3 unformed stools daily for \u22652 days with or without laboratory confirmation of C. difficile<\/em>, or death within 56 days.<\/p>\n\n\n\n

Results<\/p>\n\n\n\n

The study was stopped due to futility after meeting prespecified criteria. Of 153 participants (76 FMT, 77 placebo) with an average age of 66.5 years, 25 participants (32.9%) in the FMT arm and 23 (29.9%) in the placebo arm experienced the primary endpoint of diarrhea and possible or definite CDI recurrence or death within 56 days of capsule administration (absolute difference, 3.0% [95% confidence interval, \u221211.7% to 17.7%]). Stratification by number of recurrences revealed no statistically significant differences. There were no clinically important differences in adverse events.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
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Conclusions<\/p>\n\n\n\n

FMT therapy versus placebo did not reduce CDI recurrence or death at 56 days. There were no meaningful differences in adverse events between treatment groups.<\/p>\n\n\n\n

Clinical Trials Registration<\/p>\n\n\n\n

NCT03005379.<\/p>\n","protected":false},"excerpt":{"rendered":"

A Randomized Controlled Trial of Efficacy and Safety of […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27829"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27829"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27829\/revisions"}],"predecessor-version":[{"id":28183,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27829\/revisions\/28183"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}