{"id":27767,"date":"2025-04-12T04:29:00","date_gmt":"2025-04-11T20:29:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=27767"},"modified":"2025-04-12T06:18:54","modified_gmt":"2025-04-11T22:18:54","slug":"chest%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e4%bc%b4%e8%82%ba%e5%ad%a2%e5%ad%90%e8%99%ab%e5%ae%9a%e6%a4%8d%e7%9a%84%e9%87%8d%e7%97%87%e8%82%ba%e7%82%8e%e6%82%a3%e8%80%85%e7%9a%84%e4%b8%b4","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=27767","title":{"rendered":"[Chest\u53d1\u8868\u8bba\u6587]\uff1a\u4f34\u80ba\u5b62\u5b50\u866b\u5b9a\u690d\u7684\u91cd\u75c7\u80ba\u708e\u60a3\u8005\u7684\u4e34\u5e8a\u7279\u5f81\u53ca\u9884\u540e"},"content":{"rendered":"\n

Clinical Characteristics and Prognosis of Patients With Severe Pneumonia With\u00a0Pneumocystis jirovecii<\/em>\u00a0Colonization: A Multicenter, Retrospective Study<\/h1>\n\n\n\n

Yongpo\u00a0Jiang,\u00a0Xiaohan\u00a0Huang,\u00a0Huili\u00a0Zhou,\u00a0et al<\/h3>\n\n\n\n

Chest 2025; 167: 54-66<\/h3>\n\n\n\n

DOI:\u00a010.1016\/j.chest.2024.07.140<\/a><\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

For decades, the incidence and clinical characteristics of Pneumocystis jirovecii<\/em> colonization in patients with severe pneumonia was unclear.<\/p>\n\n\n\n

Research Question<\/h3>\n\n\n\n

What are the clinical features and outcomes associated with P jirovecii<\/em> colonization in individuals diagnosed with severe pneumonia?<\/p>\n\n\n\n

Study Design and Methods<\/h3>\n\n\n\n

In this multicenter, retrospective, matched study, patients with severe pneumonia who underwent bronchoalveolar lavage clinical metagenomics from 2019 to 2023 in the ICUs of 17 medical centers were enrolled. Patients were diagnosed based on clinical metagenomics, pulmonary CT scans, and clinical presentations. Clinical data were collected retrospectively, and according to propensity score matching and Cox multivariate regression analysis, the prognosis of patients with P jirovecii<\/em> colonization was compared with that of patients who were P jirovecii<\/em>-negative.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

A total of 40%\u00a0of\u00a0P jirovecii<\/em>-positive patients are considered to have\u00a0P jirovecii<\/em>\u00a0colonization. The\u00a0P jirovecii<\/em>\u00a0colonization group had a higher proportion of patients with immunosuppression and a lower lymphocyte count than the\u00a0P jirovecii<\/em>-negative group. More frequent detection of cytomegalovirus, Epstein-Barr virus, human herpesvirus-6B, human herpesvirus-7, and torque teno virus in the lungs was associated with\u00a0P jirovecii<\/em>\u00a0colonization than with\u00a0P jirovecii<\/em>\u00a0negativity. By constructing two cohorts through propensity score matching, we incorporated codetected microorganisms and clinical features into a Cox proportional hazards model and revealed that\u00a0P jirovecii<\/em>\u00a0colonization was an independent risk factor for mortality in patients with severe pneumonia. According to sensitivity analyses, which included or excluded codetected microorganisms, and patients not receiving trimethoprim-sulfamethoxazole treatment, similar conclusions were reached.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Interpretation<\/h3>\n\n\n\n

Immunosuppression and a reduced lymphocyte count were identified as risk factors for P jirovecii<\/em> colonization in patients with non-Pneumocystis pneumonia. More frequent detection of various viruses was observed in patients colonized with P jirovecii<\/em>, and P jirovecii<\/em> colonization was associated with an increased 28-day mortality in patients with severe pneumonia.<\/p>\n","protected":false},"excerpt":{"rendered":"

Clinical Characteristics and Prognosis of Patients With […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27767"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27767"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27767\/revisions"}],"predecessor-version":[{"id":27768,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27767\/revisions\/27768"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}