{"id":27753,"date":"2025-04-11T04:42:00","date_gmt":"2025-04-10T20:42:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=27753"},"modified":"2025-04-11T05:34:25","modified_gmt":"2025-04-10T21:34:25","slug":"lancet-infect-dis%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e4%b8%ad%e5%9b%bd%e6%96%b0%e5%8f%91%e8%84%be%e5%aa%92%e8%99%be%e5%a4%b7%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e7%b3%bb%e5%88%97%e7%97%85","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=27753","title":{"rendered":"[Lancet Infect Dis\u53d1\u8868\u8bba\u6587]\uff1a\u4e2d\u56fd\u65b0\u53d1\u813e\u5a92\u867e\u5937\u75c5\u6bd2\u611f\u67d3\u7cfb\u5217\u75c5\u4f8b\uff1a\u4e3b\u52a8\u76d1\u6d4b\u4e0e\u57fa\u56e0\u7ec4\u5206\u6790"},"content":{"rendered":"\n

A series of patients infected with the emerging tick-borne Yezo virus in China: an active surveillance and genomic analysis<\/h1>\n\n\n\n

Ming-Zhu\u00a0Zhang,\u00a0Cai\u00a0Bian,\u00a0Run-Ze\u00a0Ye, et al<\/h3>\n\n\n\n

Lancet Infect Dis Available online 7 November 2024<\/h3>\n\n\n\n

https:\/\/doi.org\/10.1016\/S1473-3099(24)00616-9<\/h3>\n\n\n\n

Summary<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

Yezo virus (YEZV) is an emerging tick-borne pathogen, which was initially reported in Japan in 2021. Only one patient had been reported in China so far. We aimed to describe the epidemiological, clinical, and laboratory findings of a series of patients, and to characterise the viral genomes of YEZV.<\/p>\n\n\n\n

\u80cc\u666f\uff1a\u867e\u5937\u75c5\u6bd2\uff08YEZV\uff09\u662f\u4e00\u79cd\u65b0\u53d1\u8731\u5a92\u75c5\u539f\u4f53\uff0c\u6700\u521d\u4e8e 2021 \u5e74\u5728\u65e5\u672c\u62a5\u544a\u3002\u8fc4\u4eca\u4e3a\u6b62\u4e2d\u56fd\u4ec5\u62a5\u544a\u4e86\u4e00\u4f8b\u60a3\u8005\u3002\u6211\u4eec\u65e8\u5728\u63cf\u8ff0\u7cfb\u5217\u75c5\u4f8b\u7684\u6d41\u884c\u75c5\u5b66\u3001\u4e34\u5e8a\u548c\u5b9e\u9a8c\u5ba4\u7ed3\u679c\uff0c\u5e76\u63cf\u8ff0 YEZV \u57fa\u56e0\u7ec4\u7279\u5f81\u3002<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

In this active surveillance and genomic analysis, we conducted active surveillance at Mudanjiang Forestry Central Hospital, Heilongjiang Province of northeast China. Participants were eligible for inclusion if they sought medical care for a recent tick bite between May 1 and July 31, in 2022 and 2023, and between May 1 and July 10, in 2024. We collected sera from participants to detect YEZV infection by meta-transcriptomic sequencing, real-time RT-PCR, and indirect immunofluorescence assay. We isolated YEZV by cell culture and characterised the pathogen by morphological and phylogenetic analyses.<\/p>\n\n\n\n

\u65b9\u6cd5\uff1a\u5728\u4e2d\u56fd\u4e1c\u5317\u9ed1\u9f99\u6c5f\u7701\u7684\u7261\u4e39\u6c5f\u6797\u4e1a\u4e2d\u5fc3\u533b\u9662\u8fdb\u884c\u4e3b\u52a8\u76d1\u6d4b\u548c\u57fa\u56e0\u7ec4\u5206\u6790\u3002\u53c2\u4e0e\u8005\u7eb3\u5165\u6807\u51c6\u4e3a 2022 \u548c 2023 \u5e74 5 \u6708 1 \u65e5\u81f3 7 \u6708 31 \u65e5\u4ee5\u53ca 2024 \u5e74 5 \u67081 \u65e5\u81f3 7 \u6708 10 \u65e5\u671f\u95f4\uff0c\u56e0\u8fd1\u671f\u88ab\u8731\u53ee\u54ac\u800c\u5c31\u8bca\u8005\u3002\u6211\u4eec\u91c7\u96c6\u53c2\u4e0e\u8005\u7684\u8840\u6e05\uff0c\u901a\u8fc7\u5b8f\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u3001\u5b9e\u65f6 RT-PCR \u548c\u95f4\u63a5\u514d\u75ab\u8367\u5149\u8bd5\u9a8c\u68c0\u6d4b YEZV \u611f\u67d3\u3002\u901a\u8fc7\u7ec6\u80de\u57f9\u517b\u5206\u79bb YEZV\uff0c\u5e76\u8fdb\u884c\u8be5\u75c5\u539f\u4f53\u7684\u5f62\u6001\u5b66\u548c\u7cfb\u7edf\u53d1\u80b2\u7279\u5f81\u5206\u6790\u3002<\/p>\n\n\n\n

Findings<\/h3>\n\n\n\n

A series of 18 patients with YEZV infection (12 male and six female; median age 53 years, IQR 45\u201360) were identified among 988 participants. The patients presented with fever (18 patients, 100%), headache (ten patients, 56%), dizziness (nine patients, 50%), malaise (three patients, 17%), lumbago (three patients, 17%), and cough (three patients, 17%). Nine (50%) patients had rash around the tick bite site and four (22%) had lymphadenopathy. Nine (50%) patients had gastrointestinal symptoms, and five (28%) had neurological symptoms. We observed leukopenia in ten (63%) and thrombocytopenia in five (31%) of 16 assessed patients. Elevated hepatic transaminase concentrations were identified in 13 (72%) of all 18 patients, lactate dehydrogenase or \u03b1-hydroxybutyric dehydrogenase in nine (50%), serum amyloid protein A in 13 (72%), and hypersensitive C-reactive protein in ten (56%). Eight (7%) of 119\u00a0Ixodes persulcatus<\/em>\u00a0ticks removed from participants were positive for YEZV. Three YEZV strains were isolated from the sera of patients. Ten viral genomes were obtained from five patients, a blood-sucking\u00a0I persulcatus<\/em>\u00a0removed from a participant, and four host-questing tick samples collected in the areas where patients were identified or in the adjacent region. Phylogenetic analyses revealed that YEZVs in either patients or ticks were divided into two clades, each with distinct mutations.<\/p>\n\n\n\n

\u53d1\u73b0\uff1a\u5728 988 \u540d\u53c2\u4e0e\u8005\u4e2d\u53d1\u73b0\u4e86 18 \u4f8b YEZV \u611f\u67d3\u60a3\u8005\uff0812 \u540d\u7537\u6027\u548c 6 \u540d\u5973\u6027\uff1b\u5e74\u9f84\u4e2d\u4f4d\u6570\u4e3a 53 \u5c81\uff0c\u56db\u5206\u4f4d\u6570\u5728 45\u201360 \u5c81\u4e4b\u95f4\uff09\u3002\u60a3\u8005\u8868\u73b0\u51fa\u53d1\u70ed\uff0818\u4f8b\uff0c100%\uff09\u3001\u5934\u75db\uff0810 \u4f8b\uff0c56%\uff09\u3001\u5934\u6655\uff089 \u4f8b\uff0c50%\uff09\u3001\u4e4f\u529b\uff083 \u4f8b\uff0c17%\uff09\u3001\u8170\u75db\uff083 \u4f8b\uff0c17%\uff09\u548c\u54b3\u55fd\uff083 \u4f8b\uff0c17%\uff09\u30029 \u540d\u60a3\u8005\uff0850%\uff09\u5728\u8731\u54ac\u5904\u51fa\u73b0\u76ae\u75b9\uff0c4 \u540d\u60a3\u8005\uff0822%\uff09\u6709\u6dcb\u5df4\u7ed3\u80bf\u5927\u30029 \u540d\u60a3\u8005\uff0850%\uff09\u51fa\u73b0\u80c3\u80a0\u75c7\u72b6\uff0c5 \u540d\u60a3\u8005\uff0828%\uff09\u6709\u795e\u7ecf\u7cfb\u7edf\u75c7\u72b6\u3002\u5728 16 \u540d\u6709\u8840\u5e38\u89c4\u68c0\u6d4b\u7ed3\u679c\u7684\u60a3\u8005\u4e2d\uff0c10 \u540d\uff0863%\uff09\u51fa\u73b0\u767d\u7ec6\u80de\u51cf\u5c11\uff0c5 \u540d\uff0831%\uff09\u51fa\u73b0\u8840\u5c0f\u677f\u51cf\u5c11\u3002\u5168\u90e8 18 \u540d\u60a3\u8005\u4e2d\uff0c13 \u540d\uff0872%\uff09\u809d\u8f6c\u6c28\u9176\u5347\u9ad8\uff0c9 \u540d\uff0850%\uff09\u4e73\u9178\u8131\u6c22\u9176\u6216 \u03b1-\u7f9f\u57fa\u4e01\u9178\u8131\u6c22\u9176\u5347\u9ad8\uff0c13\u540d\uff0872%\uff09\u8840\u6e05\u6dc0\u7c89\u6837\u86cb\u767d A \u5347\u9ad8\uff0c10 \u540d\uff0856%\uff09\u8d85\u654f C \u53cd\u5e94\u86cb\u767d\u5347\u9ad8\u3002\u4ece\u53c2\u4e0e\u8005\u8eab\u4e0a\u6458\u53d6\u7684\u6b63\u5728\u5438\u8840\u7684 119 \u53ea\u5168\u6c9f\u786c\u8731\u4e2d\uff0c8 \u53ea\uff087%\uff09YEZV \u9633\u6027\u3002\u4ece\u60a3\u8005\u8840\u6e05\u4e2d\u5206\u79bb\u5230 3 \u682a YEZV\uff0c\u5e76\u83b7\u5f97\u4e86 10 \u5957\u75c5\u6bd2\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u5176\u4e2d 5 \u5957\u6765\u81ea\u75c5\u4eba\u30011 \u5957\u6765\u81ea\u4ece\u53c2\u4e0e\u8005\u8eab\u4e0a\u6458\u53d6\u7684\u6b63\u5728\u5438\u8840\u7684\u8731\u30014 \u5957\u6765\u81ea\u4ece\u60a3\u8005\u5c45\u4f4f\u5730\u57df\u53ca\u5468\u8fb9\u5730\u533a\u91c7\u96c6\u7684\u6e38\u79bb\u8731\u3002\u7cfb\u7edf\u53d1\u80b2\u5206\u6790\u663e\u793a\uff0c\u60a3\u8005\u6216\u8731\u4e2d\u7684 YEZV \u5206\u4e3a\u4e24\u4e2a\u8fdb\u5316\u5206\u679d\uff0c\u6bcf\u4e2a\u5206\u679d\u5177\u6709\u72ec\u7279\u7684\u7a81\u53d8\u4f4d\u70b9\u3002<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Interpretation<\/h3>\n\n\n\n

Awareness of YEZV infection is important and clinicians should consider the virus when diagnosing patients with suitable symptoms.<\/p>\n\n\n\n

\u89e3\u8bfb\uff1a\u5bf9 YEZV \u611f\u67d3\u7684\u8ba4\u8bc6\u5f88\u91cd\u8981\uff0c\u4e34\u5e8a\u533b\u751f\u5bf9\u5177\u6709\u76f8\u5e94\u4e34\u5e8a\u8868\u73b0\u7684\u60a3\u8005\u5e94\u8003\u8651\u5230\u8be5\u75c5\u6bd2\u7684\u611f\u67d3\u3002<\/p>\n\n\n\n

Funding<\/h3>\n\n\n\n

National Key Research and Development Program of China.<\/p>\n\n\n\n

\u8d44\u52a9\uff1a\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212<\/p>\n\n\n\n

Translation<\/h3>\n\n\n\n

For the Chinese translation of the abstract see Supplementary Materials section.<\/p>\n","protected":false},"excerpt":{"rendered":"

A series of patients infected with the emerging tick-bo […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27753"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27753"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27753\/revisions"}],"predecessor-version":[{"id":27754,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27753\/revisions\/27754"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}