{"id":27495,"date":"2025-02-26T04:57:00","date_gmt":"2025-02-25T20:57:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=27495"},"modified":"2025-02-26T05:57:47","modified_gmt":"2025-02-25T21:57:47","slug":"jama-netw-open%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9amssa%e6%84%9f%e6%9f%93%e6%80%a7%e5%bf%83%e5%86%85%e8%86%9c%e7%82%8e%e7%9a%84%ce%b2-%e5%86%85%e9%85%b0%e8%83%ba%e6%8e%a5%e7%a7%8d%e6%95%88","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=27495","title":{"rendered":"[JAMA Netw Open\u53d1\u8868\u8bba\u6587]\uff1aMSSA\u611f\u67d3\u6027\u5fc3\u5185\u819c\u708e\u7684\u03b2-\u5185\u9170\u80fa\u63a5\u79cd\u6548\u5e94"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

Infectious Diseases<\/p>\n\n\n\n

December 20, 2024<\/p>\n\n\n\n

\u03b2-Lactam Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus<\/em> Infective Endocarditis<\/h1>\n\n\n\n

Baptiste Jean, Maelys Crolle, Candice Pollani, et al<\/h3>\n\n\n\n

JAMA Netw Open. <\/em>2024;7(12):e2451353. doi:10.1001\/jamanetworkopen.2024.51353<\/h3>\n\n\n\n

<\/a>Key Points<\/p>\n\n\n\n

Question<\/strong>  Is the clinical outcome of methicillin-susceptible Staphylococcus aureus <\/em>(MSSA) infective endocarditis associated with some underappreciated phenotypic characteristics of the bacterial strains and the \u03b2-lactam used?<\/p>\n\n\n\n

Findings<\/strong>  In this case series of 216 patients with MSSA, first-month mortality in infective left-sided endocarditis due to MSSA strains appeared to be independently associated with the presence of blaZ<\/em> and an inoculum effect, and this may account for some differences in outcomes between antistaphylococcal penicillin and cefazolin.<\/p>\n\n\n\n

Meaning<\/strong>  These findings suggest that characterizing the presence of blaZ<\/em> and an inoculum effect may help to select the best treatment for MSSA infective endocarditis and improve clinical outcomes.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Infective endocarditis (IE) caused by Staphylococcus aureus<\/em> is associated with high mortality, approximately 20% to 30%, mostly in the first month, with no improvement in recent decades. Current opinion is that antistaphylococcal penicillin and cefazolin are equally effective in treating methicillin-susceptible S aureus<\/em> (MSSA) IE, and both are recommended as possible first-line treatments. Most MSSA strains carry the \u03b2-lactamase blaZ<\/em> gene, and some blaZ<\/em>-positive strains exhibit an inoculum effect, meaning increased minimum inhibitory concentrations at high inoculum. This reduced susceptibility to an antibiotic at high bacterial inoculum may be particularly relevant in IE, where vegetations have very high bacterial densities.<\/p>\n\n\n\n

Objective<\/strong>  To evaluate the association between phenotypic characteristics of S aureus<\/em> isolates, \u03b2-lactam used, and outcome in patients with MSSA IE.<\/p>\n\n\n\n

Design, Settings, and Participants<\/strong>  This retrospective case series included MSSA cases treated at 3 French university hospitals between February 2016 and February 2022. The study included patients who had clinical isolates available and had definite or possible S aureus<\/em> IE that involved native or prosthetic valves. Data were analyzed from July 2023 to June 2024.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  MSSA isolates were tested for the presence of blaZ<\/em> and for inoculum effects to cefazolin and oxacillin. The association between first-month mortality and the \u03b2-lactam used, the presence of blaZ<\/em>, and the presence of an inoculum effect to the treatment received was evaluated.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0This study included 216 patients with MSSA IE (median [IQR] age, 65 [49-73] years; 152 [70.4%] male) who were treated with antistaphylococcal penicillin (139 [64.4%]) or cefazolin (77 [35.6%]). One-month mortality of left-sided IE was 44 of 180 patients (24.4%), with no overall difference between patients treated with antistaphylococcal penicillin or cefazolin. However, 1-month mortality was higher in patients infected with\u00a0blaZ<\/em>-positive strains than with\u00a0blaZ<\/em>-negative strains (38 of 129 [29.5%] vs 6 of 51 [11.8%];\u00a0P<\/em>\u2009=\u2009.01), and with strains with an inoculum effect to the \u03b2-lactam received than with strains without an inoculum effect (25 of 62 [40.3%] vs 13 of 67 [19.4%];\u00a0P<\/em>\u2009=\u2009.005). On multivariable analysis, the presence of an inoculum effect was independently associated with first-month mortality (HR, 2.84; 95% CI, 1.28-6.30;\u00a0P<\/em>\u2009=\u2009.01).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  In this case series of MSSA IE, the presence of an inoculum effect to the \u03b2-lactam received was a risk factor for death in the first month. Phenotyping MSSA isolates for inoculum effect may guide \u03b2-lactam choice and improve outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  Infectious Diseases Decemb […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27495"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27495"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27495\/revisions"}],"predecessor-version":[{"id":27857,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27495\/revisions\/27857"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27495"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}