{"id":27217,"date":"2025-01-29T04:36:00","date_gmt":"2025-01-28T20:36:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=27217"},"modified":"2025-01-29T06:16:13","modified_gmt":"2025-01-28T22:16:13","slug":"clin-infect-dis%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e9%87%8d%e5%ba%a6%e9%a2%85%e8%84%91%e6%8d%9f%e4%bc%a4%e6%82%a3%e8%80%85%e7%9c%9f%e8%8f%8c%e6%84%9f%e6%9f%93%e7%9a%84%e5%8d%b1%e9%99%a9","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=27217","title":{"rendered":"[Clin Infect Dis\u53d1\u8868\u8bba\u6587]\uff1a\u91cd\u5ea6\u70e7\u4f24\u60a3\u8005\u771f\u83cc\u611f\u67d3\u7684\u5371\u9669\u56e0\u7d20\u53ca\u9884\u540e"},"content":{"rendered":"\n

Risk Factors and Outcome Associated With Fungal Infections in Patients With Severe Burn Injury: 10-year Retrospective IFI-BURN Study <\/h1>\n\n\n\n

Emmanuel Dudoignon,  Sylvie Chevret,  Sorel Tsague,  et al<\/h3>\n\n\n\n

Clinical Infectious Diseases<\/em>, Volume 79, Issue 3, 15 September 2024, Pages 682\u2013689, https:\/\/doi.org\/10.1093\/cid\/ciae337<\/a><\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/p>\n\n\n\n

In burn patients, skin barrier disruption and immune dysfunctions increase susceptibility to invasive fungal diseases (IFDs) like invasive candidiasis (IC) and invasive mold infections (IMI). We provide an in-depth analysis of IFD-related factors and outcomes in a 10-year cohort of severe burn patients.<\/p>\n\n\n\n

Methods<\/p>\n\n\n\n

This retrospective cohort study includes adult patients admitted to the burn intensive care unit (BICU) between April 2014 and May 2023 with total burn surface area (TBSA) \u226515%. Patients were classified as proven IFD according to EORTC\/MSGERC criteria applicable for IC. Putative IMIs were defined with: \u22652 positive cultures from a skin biopsy\/bronchoalveolar lavage or \u22652 positive blood specific-quantitative polymerase chain reactions (qPCRs) or a combination of both.<\/p>\n\n\n\n

Results<\/p>\n\n\n\n

Among 1381 patients admitted, 276 consecutive patients with TBSA \u226515% were included. Eighty-seven (31.5%; IC n = 30; IMI n = 43; both n = 14) patients fulfilled the criteria for probable\/putative IFD. At Day 30 after the burn injury, the estimated cumulative incidence proven\/putative (pr\/pu) IFD was 26.4% (95% confidence interval [CI], 21.4%\u201331.8%). Factors independently associated with IFDs were TBSA, severity scores and indoor burn injury (ie, from confined space fire). Overall mortality was 15.3% and 36.8% in the no IFD, pr\/pu IFD groups respectively (P<\/em>\u00a0< .0001). IFD was independently associated with a risk of death (hazard ratio [HR]: 1.94 for pr\/pu IFD; 95% CI, 1.12\u20133.36;\u00a0P<\/em>\u00a0= .019).<\/p>\n\n\n\n

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Conclusions<\/p>\n\n\n\n

This study describes twenty-first-century characteristics of IFDs in severe burn patients confirming known risk factors with thresholds and identifying the indoor injury as an independent factor associated to IFDs. This suggests a link to contamination caused by fire damage, which is highly susceptible to aerosolizing spores.<\/p>\n","protected":false},"excerpt":{"rendered":"

Risk Factors and Outcome Associated With Fungal Infecti […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27217"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27217"}],"version-history":[{"count":3,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27217\/revisions"}],"predecessor-version":[{"id":27617,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27217\/revisions\/27617"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}