{"id":27137,"date":"2025-01-12T04:42:00","date_gmt":"2025-01-11T20:42:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=27137"},"modified":"2025-01-12T07:24:05","modified_gmt":"2025-01-11T23:24:05","slug":"jama-netw-open%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%af%8d%e4%ba%b2%e5%92%8c%e6%96%b0%e7%94%9f%e5%84%bfabo%e8%a1%80%e5%9e%8b%e4%b8%8e%e6%96%b0%e7%94%9f%e5%84%bf%e7%bb%86%e8%8f%8c%e6%84%9f","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=27137","title":{"rendered":"[JAMA Netw Open\u53d1\u8868\u8bba\u6587]\uff1a\u6bcd\u4eb2\u548c\u65b0\u751f\u513fABO\u8840\u578b\u4e0e\u65b0\u751f\u513f\u7ec6\u83cc\u611f\u67d3\u98ce\u9669"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

Pediatrics<\/p>\n\n\n\n

October 30, 2024<\/p>\n\n\n\n

Maternal-Newborn ABO Blood Groups and Risk of Bacterial Infection in Newborns<\/h1>\n\n\n\n

Emily Ana Butler, Joel G. Ray, Eyal Cohen<\/h3>\n\n\n\n

JAMA Netw Open. <\/em>2024;7(10):e2442227. doi:10.1001\/jamanetworkopen.2024.42227<\/h3>\n\n\n\n

<\/a>Key Points<\/p>\n\n\n\n

Question<\/strong>  If a mother and newborn have incongruent ABO blood groups, is the newborn at a lower risk of bacterial infection than if they had congruent ABO blood group?<\/p>\n\n\n\n

Findings<\/strong>  In this cohort study of 138 207 mother-newborn pairs, ABO blood group incongruence was not associated with a lower risk of bacterial infection within 30 days of birth.<\/p>\n\n\n\n

Meaning<\/strong>  Findings of this study suggest ABO blood group incongruence is not associated with a lower risk of bacterial infection within 30 days of birth.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Newborn immunity largely relies on maternal-fetal transfer of antibodies in utero. Incongruency in ABO blood groups between a mother and newborn may be associated with protection against serious infections, but data specific to newborn bacterial infections are lacking.<\/p>\n\n\n\n

Objective<\/strong>  To ascertain the association between maternal-newborn ABO blood group incongruence and lower risk of bacterial infection in newborns.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  This cohort study used linked patient-level datasets for all singleton live births between January 1, 2014, and December 31, 2020, in hospitals and health centers in Ontario, Canada. The cohort comprised maternal-newborn pairs with known ABO blood groups. Data analysis was conducted between February and May 2024.<\/p>\n\n\n\n

Exposure<\/strong>  Maternal-newborn ABO blood group incongruence vs congruence.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was a bacterial infection arising in newborns within 30 days of birth. Bacterial infection was cultured from either blood, cerebrospinal fluid, urine, or lung specimen. Secondary outcomes were a bacterial infection with 7 days and 90 days of birth. Modified Poisson regression generated adjusted relative risks (ARRs) and 95% CIs, adjusted for neonatal sex and preterm birth.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0A total of 138 207 maternal-newborn pairs (maternal mean [SD] age, 31.8 [5.1] years among those with ABO blood group incongruency and 31.5 [5.1] years among those with ABO blood group congruency; newborn mean [SD] gestational age, 38.5 [2.3] weeks among those with incongruency and 38.4 [2.5] weeks among those with congruency; 19\u202f475 males [51.3%] with incongruency and 52\u202f041 males [51.9%] with congruency) were analyzed. Of these pairs, 37 953 (27.5%) had ABO blood group incongruency and 100 254 (72.5%) had ABO blood group congruency. Within 30 days of birth, 328 (8.6 per 1000) newborns in the incongruent group and 1029 (10.3 per 1000) newborns in the congruent group experienced a bacterial infection, corresponding to an ARR of 0.91 (95% CI, 0.81-1.03). The ARRs for bacterial infection within 7 days and 90 days of birth were 0.89 (95% CI, 0.73-1.09) and 0.86 (95% CI, 0.78-0.94), respectively.<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  This cohort study found no association between maternal-newborn ABO blood group incongruence and risk of bacterial infection in newborns within 30 and 7 days of birth. However, incongruence was associated with a decreased risk of bacterial infection within 90 days of birth.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  Pediatrics October 30 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27137"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27137"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27137\/revisions"}],"predecessor-version":[{"id":27533,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/27137\/revisions\/27533"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=27137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=27137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}