{"id":26847,"date":"2024-11-11T04:50:00","date_gmt":"2024-11-10T20:50:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=26847"},"modified":"2024-11-11T05:30:07","modified_gmt":"2024-11-10T21:30:07","slug":"nejm%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e4%b8%a5%e9%87%8d%e4%bd%8e%e6%b0%a7%e8%a1%80%e7%97%87%e6%82%a3%e8%80%85%e6%af%8f%e6%97%a524%e5%b0%8f%e6%97%b6%e6%88%9615%e5%b0%8f%e6%97%b6%e9%95%bf","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=26847","title":{"rendered":"[NEJM\u53d1\u8868\u8bba\u6587]\uff1a\u4e25\u91cd\u4f4e\u6c27\u8840\u75c7\u60a3\u8005\u6bcf\u65e524\u5c0f\u65f6\u621615\u5c0f\u65f6\u957f\u671f\u6c27\u7597"},"content":{"rendered":"\n

ORIGINAL ARTICLE<\/a><\/p>\n\n\n\n

Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia<\/h1>\n\n\n\n

Magnus\u00a0Ekstr\u00f6m,\u00a0Anders\u00a0Andersson,\u00a0Savvas\u00a0Papadopoulos,\u00a0et al<\/h3>\n\n\n\n

N Engl J Med\u00a02024;391:977-988<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

BACKGROUND<\/h3>\n\n\n\n

Long-term oxygen supplementation for at least 15 hours per day prolongs survival among patients with severe hypoxemia. On the basis of a nonrandomized comparison, long-term oxygen therapy has been recommended to be used for 24 hours per day, a more burdensome regimen.<\/p>\n\n\n\n

METHODS<\/h3>\n\n\n\n

To test the hypothesis that long-term oxygen therapy used for 24 hours per day does not result in a lower risk of hospitalization or death at 1 year than therapy for 15 hours per day, we conducted a multicenter, registry-based, randomized, controlled trial involving patients who were starting oxygen therapy for chronic, severe hypoxemia at rest. The patients were randomly assigned to receive long-term oxygen therapy for 24 or 15 hours per day. The primary outcome, assessed in a time-to-event analysis, was a composite of hospitalization or death from any cause within 1 year. Secondary outcomes included the individual components of the primary outcome assessed at 3 and 12 months.<\/a><\/p>\n\n\n\n

RESULTS<\/h3>\n\n\n\n

Between May 18, 2018, and April 4, 2022, a total of 241 patients were randomly assigned to receive long-term oxygen therapy for 24 hours per day (117 patients) or 15 hours per day (124 patients). No patient was lost to follow-up. At 12 months, the median patient-reported daily duration of oxygen therapy was 24.0 hours (interquartile range, 21.0 to 24.0) in the 24-hour group and 15.0 hours (interquartile range, 15.0 to 16.0) in the 15-hour group.\u00a0The risk of hospitalization or death within 1 year in the 24-hour group was not lower than that in the 15-hour group (mean rate, 124.7 and 124.5 events per 100 person-years, respectively; hazard ratio, 0.99; 95% confidence interval [CI], 0.72 to 1.36; 90% CI, 0.76 to 1.29; P=0.007 for nonsuperiority).\u00a0The groups did not differ substantially in the incidence of hospitalization for any cause, death from any cause, or adverse events.<\/p>\n\n\n\n

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CONCLUSIONS<\/h3>\n\n\n\n

Among patients with severe hypoxemia, long-term oxygen therapy used for 24 hours per day did not result in a lower risk of hospitalization or death within 1 year than therapy for 15 hours per day. (Funded by the Crafoord Foundation and others; REDOX ClinicalTrials.gov number, NCT03441204<\/a>.)<\/p>\n","protected":false},"excerpt":{"rendered":"

ORIGINAL ARTICLE Long-Term Oxygen Therapy for 24 or 15 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/26847"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26847"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/26847\/revisions"}],"predecessor-version":[{"id":27228,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/26847\/revisions\/27228"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}