{"id":26507,"date":"2024-09-23T04:04:00","date_gmt":"2024-09-22T20:04:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=26507"},"modified":"2024-09-23T05:48:23","modified_gmt":"2024-09-22T21:48:23","slug":"intensive-care-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%bf%83%e8%84%8f%e5%a4%96%e7%a7%91%e6%9c%af%e5%90%8e%e6%82%a3%e8%80%85%e5%bf%ab%e9%80%9f%e8%be%93%e6%b3%a820%e7%99%bd%e8%9b%8b","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=26507","title":{"rendered":"[Intensive Care Med\u53d1\u8868\u8bba\u6587]\uff1a\u5fc3\u810f\u5916\u79d1\u672f\u540e\u60a3\u8005\u5feb\u901f\u8f93\u6ce820%\u767d\u86cb\u767d"},"content":{"rendered":"\n

Twenty percent human albumin solution fluid bolus administration therapy in patients after cardiac surgery-II: a multicentre randomised controlled trial<\/h1>\n\n\n\n

Wigmore, G.J., Deane, A.M., Presneill, J.J.\u00a0et al.<\/em><\/h3>\n\n\n\n

Intensive Care Med<\/em>\u00a050<\/strong>, 1075\u20131085 (2024)<\/h3>\n\n\n\n

https:\/\/doi.org\/10.1007\/s00134-024-07488-3<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Purpose<\/h3>\n\n\n\n

After cardiac surgery, fluid bolus therapy (FBT) with 20% human albumin may facilitate less fluid and vasopressor administration than FBT with crystalloids. We aimed to determine whether, after cardiac surgery, FBT with 20% albumin reduces the duration of vasopressor therapy compared with crystalloid FBT.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

We conducted a multicentre, parallel-group, open-label, randomised clinical trial in six intensive care units (ICUs) involving cardiac surgery patients deemed to require FBT. We randomised 240 patients to receive up to 400 mL of 20% albumin\/day as FBT, followed by 4% albumin for any subsequent FBT on that day, or to crystalloid FBT for at least the first 1000 mL, with use of crystalloid or 4% albumin FBT thereafter. The primary outcome was the cumulative duration of vasopressor therapy. Secondary outcomes included fluid balance.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

Of 480 randomised patients, 466 provided consent and contributed to the primary outcome (mean age 65 years; median EuroSCORE II 1.4). The cumulative median duration of vasopressor therapy was 7 (interquartile range [IQR] 0\u201319.6) hours\u00a0with 20% albumin and 10.8 (IQR 0\u201322.8) hours\u00a0with crystalloids (difference \u2212\u20093.8 h, 95% confidence interval [CI] \u2212\u20098 to 0.4;\u00a0P<\/em>\u2009=\u20090.08). Day one fluid balance was less with 20% albumin FBT (mean difference \u2212\u2009701 mL, 95% CI \u2212\u2009872 to \u2212\u2009530).<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

Conclusions<\/h3>\n\n\n\n

In patients after cardiac surgery, when compared to a crystalloid-based FBT, 20% albumin FBT was associated with a reduced positive fluid balance but did not significantly reduce the duration of vasopressor therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"

Twenty percent human albumin solution fluid bolus admin […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/26507"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26507"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/26507\/revisions"}],"predecessor-version":[{"id":26510,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/26507\/revisions\/26510"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}