{"id":25814,"date":"2024-05-31T04:42:00","date_gmt":"2024-05-30T20:42:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=25814"},"modified":"2024-05-31T06:04:46","modified_gmt":"2024-05-30T22:04:46","slug":"bmj%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%be%b3%e5%a4%a7%e5%88%a9%e4%ba%9a%e6%96%b0%e5%8d%97%e5%a8%81%e5%b0%94%e5%a3%ab%e5%b7%9e%e4%bd%8f%e9%99%a2%e6%82%a3%e8%80%85%e4%b8%ad%e7%9a%84","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=25814","title":{"rendered":"[BMJ\u53d1\u8868\u8bba\u6587]\uff1a\u6fb3\u5927\u5229\u4e9a\u65b0\u5357\u5a01\u5c14\u58eb\u5dde\u4f4f\u9662\u60a3\u8005\u4e2d\u7684\u8c35\u5984\u4e0e\u5076\u53d1\u6027\u75f4\u5446"},"content":{"rendered":"\n

Research<\/strong><\/p>\n\n\n\n

Delirium and incident dementia in hospital patients in New South Wales, Australia: retrospective cohort study<\/h1>\n\n\n\n

Emily H Gordon<\/a>, David D Ward<\/a>, Hao Xiong<\/a>, et al<\/h3>\n\n\n\n

BMJ<\/em>\u00a02024;\u00a0384\u00a0doi:\u00a0https:\/\/doi.org\/10.1136\/bmj-2023-077634<\/a>\u00a0(Published 27 March 2024)Cite this as:\u00a0BMJ<\/em>\u00a02024;384:e077634<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Objectives<\/strong> To determine the strength and nature of the association between delirium and incident dementia in a population of older adult patients without dementia at baseline.<\/p>\n\n\n\n

Design<\/strong> Retrospective cohort study using large scale hospital administrative data.<\/p>\n\n\n\n

Setting<\/strong> Public and private hospitals in New South Wales, Australia between July 2001 and March 2020.<\/p>\n\n\n\n

Participants<\/strong> Data were extracted for 650\u2009590 hospital patients aged \u226565 years. Diagnoses of dementia and delirium were identified from ICD-10 (international classification of diseases, 10th revision) codes. Patients with dementia at baseline were excluded. Delirium-no delirium pairs were identified by matching personal and clinical characteristics, and were followed for more than five years.<\/p>\n\n\n\n

Main outcome measures<\/strong> Cox proportional hazards models and Fine-Gray hazard models were used to estimate the associations of delirium with death and incident dementia, respectively. Delirium-outcome dose-response associations were quantified, all analyses were performed in men and women separately, and sensitivity analyses were conducted.<\/p>\n\n\n\n

Results<\/strong>\u00a0The study included 55\u2009211 matched pairs (48% men, mean age 83.4 years, standard deviation 6.5 years). Collectively, 58% (n=63\u2009929) of patients died and 17% (n=19\u2009117) had a newly reported dementia diagnosis during 5.25 years of follow-up. Patients with delirium had 39% higher risk of death (hazard ratio 1.39, 95% confidence interval 1.37 to 1.41) and three times higher risk of incident dementia (subdistribution hazard ratio 3.00, 95% confidence interval 2.91 to 3.10) than patients without delirium. The association with dementia was stronger in men (P=0.004). Each additional episode of delirium was associated with a 20% increased risk of dementia (subdistribution hazard ratio 1.20, 95% confidence interval 1.18 to 1.23).<\/p>\n\n\n\n

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Conclusions<\/strong> The study findings suggest delirium was a strong risk factor for death and incident dementia among older adult patients. The data support a causal interpretation of the association between delirium and dementia. The clinical implications of delirium as a potentially modifiable risk factor for dementia are substantial.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research Delirium and incident dementia in hospital pat […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25814"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25814"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25814\/revisions"}],"predecessor-version":[{"id":25815,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25814\/revisions\/25815"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}