{"id":25808,"date":"2024-05-30T04:57:00","date_gmt":"2024-05-29T20:57:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=25808"},"modified":"2024-05-30T05:52:27","modified_gmt":"2024-05-29T21:52:27","slug":"jama-netw-open%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87-%e8%af%8a%e6%96%ad%e8%82%9d%e7%b4%a0%e8%af%b1%e5%af%bc%e8%a1%80%e5%b0%8f%e6%9d%bf%e5%87%8f%e5%b0%91%e7%9a%84%e5%87%86%e7%a1%ae%e6%80%a7","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=25808","title":{"rendered":"[JAMA Netw Open\u53d1\u8868\u8bba\u6587]: \u8bca\u65ad\u809d\u7d20\u8bf1\u5bfc\u8840\u5c0f\u677f\u51cf\u5c11\u7684\u51c6\u786e\u6027"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

Hematology<\/p>\n\n\n\n

March 26, 2024<\/p>\n\n\n\n

Accuracy of Diagnosing Heparin-Induced Thrombocytopenia<\/h1>\n\n\n\n

Emil List\u00a0Larsen,\u00a0Henning\u00a0Nilius,\u00a0Jan-Dirk\u00a0Studt,\u00a0et al<\/h3>\n\n\n\n

JAMA Netw Open.\u00a0<\/em>2024;7(3):e243786. doi:10.1001\/jamanetworkopen.2024.3786<\/h3>\n\n\n\n

<\/a>Key Points<\/p>\n\n\n\n

Question<\/strong>  Is the current diagnostic practice for suspected heparin-induced thrombocytopenia (HIT) accurate?<\/p>\n\n\n\n

Findings<\/strong>  In this diagnostic study of 1318 patients suspected of having HIT, the 4Ts score produced 9.0% false negatives; chemiluminescent immunoassay produced 4.5%; and the recommended algorithm (4Ts score followed by chemiluminescent immunoassay) produced 13.5%. These same tests produced 49.0%, 6.0%, and 4.1% false positives, respectively.<\/p>\n\n\n\n

Meaning<\/strong>  In this study, a substantial number of patients with suspected HIT were misclassified, which could lead to delayed diagnosis or overtreatment.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Heparin-induced thrombocytopenia (HIT) is a life-threatening condition that requires urgent diagnostic clarification. However, knowledge of the diagnostic utility of the recommended diagnostic tests is limited in clinical practice.<\/p>\n\n\n\n

Objective<\/strong>  To evaluate the current diagnostic practice for managing the suspicion of HIT.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  This prospective diagnostic study was conducted from January 2018 to May 2021 among consecutive patients with suspected HIT from 11 study centers in Switzerland, Germany, and the United States. Detailed clinical data and laboratory information were recorded. Platelet factor 4\/heparin antibodies were quantified using an automated chemiluminescent immunoassay (CLIA). A washed-platelet heparin-induced platelet activation (HIPA) test was used as a reference standard to define HIT.<\/p>\n\n\n\n

Exposures<\/strong>  Suspicion of HIT.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was the diagnostic accuracy of the 4Ts score, the CLIA, and the recommended algorithm serially combining both tests.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0Of 1448 patients included between 2018 and 2021, 1318 were available for the current analysis (median [IQR] age, 67 [57-75] years; 849 [64.6%] male). HIPA was positive in 111 patients (prevalence, 8.4%). The most frequent setting was intensive care unit (487 [37.0%]) or cardiovascular surgery (434 [33.0%]). The 4Ts score was low risk in 625 patients (46.8%). By 2\u2009\u00d7\u20092 table, the numbers of patients with false-negative results were 10 (9.0%; 4Ts score), 5 (4.5%; CLIA), and 15 (13.5%; recommended diagnostic algorithm). The numbers of patients with false-positive results were 592 (49.0%; 4Ts score), 73 (6.0%; CLIA), and 50 (4.1%; recommended diagnostic algorithm), respectively.<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  In this diagnostic study of patients suspected of having HIT, when the recommended diagnostic algorithm was used in clinical practice, antibody testing was required in half the patients. A substantial number of patients were, however, still misclassified, which could lead to delayed diagnosis or overtreatment. Development of improved diagnostic algorithms for HIT diagnosis should be pursued.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  Hematology March 26,& […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25808"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25808"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25808\/revisions"}],"predecessor-version":[{"id":25809,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25808\/revisions\/25809"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25808"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25808"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}