{"id":25799,"date":"2024-05-26T04:14:00","date_gmt":"2024-05-25T20:14:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=25799"},"modified":"2024-05-26T07:10:53","modified_gmt":"2024-05-25T23:10:53","slug":"jama-intern-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%88%90%e5%b9%b4%e4%bd%8f%e9%99%a2%e6%82%a3%e8%80%85%e4%b8%ad%e8%82%ba%e7%82%8e%e8%af%8a%e6%96%ad%e7%9a%84%e9%94%99%e8%af%af","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=25799","title":{"rendered":"[JAMA Intern Med\u53d1\u8868\u8bba\u6587]\uff1a\u6210\u5e74\u4f4f\u9662\u60a3\u8005\u4e2d\u80ba\u708e\u8bca\u65ad\u7684\u9519\u8bef"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

March 25, 2024<\/p>\n\n\n\n

Inappropriate Diagnosis of Pneumonia Among Hospitalized Adults<\/h1>\n\n\n\n

Ashwin B. Gupta, Scott A. Flanders, Lindsay A. Petty, et al<\/h3>\n\n\n\n

JAMA Intern Med. <\/em>Published online March 25, 2024. doi:10.1001\/jamainternmed.2024.0077<\/h3>\n\n\n\n

<\/a>Key Points<\/p>\n\n\n\n

Question<\/strong>  In hospitalized patients diagnosed with pneumonia, what is the incidence of and factors associated with inappropriate diagnosis?<\/p>\n\n\n\n

Findings<\/strong>  In this cohort study of 17\u202f290 hospitalized adults treated for pneumonia in 48 Michigan hospitals, 12.0% were inappropriately diagnosed. Older patients, those with dementia, and those presenting with altered mental status had the highest risk of being inappropriately diagnosed, and for those inappropriately diagnosed, receipt of a full antibiotic duration was associated with antibiotic-associated adverse events.<\/p>\n\n\n\n

Meaning<\/strong>  Inappropriate diagnosis of pneumonia among hospitalized adults is common, particularly among older adults with geriatric syndromes, and may be harmful.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Little is known about incidence of, risk factors for, and harms associated with inappropriate diagnosis of community-acquired pneumonia (CAP).<\/p>\n\n\n\n

Objective<\/strong>  To characterize inappropriate diagnosis of CAP in hospitalized patients.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  This prospective cohort study, including medical record review and patient telephone calls, took place across 48 Michigan hospitals. Trained abstractors retrospectively assessed hospitalized patients treated for CAP between July 1, 2017, and March 31, 2020. Patients were eligible for inclusion if they were adults admitted to general care with a discharge diagnostic code of pneumonia who received antibiotics on day 1 or 2 of hospitalization. Data were analyzed from February to December 2023.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  Inappropriate diagnosis of CAP was defined using a National Quality Forum\u2013endorsed metric as CAP-directed antibiotic therapy in patients with fewer than 2 signs or symptoms of CAP or negative chest imaging. Risk factors for inappropriate diagnosis were assessed and, for those inappropriately diagnosed, 30-day composite outcomes (mortality, readmission, emergency department visit, Clostridioides difficile <\/em>infection, and antibiotic-associated adverse events) were documented and stratified by full course (>3 days) vs brief (\u22643 days) antibiotic treatment using generalized estimating equation models adjusting for confounders and propensity for treatment.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0Of the 17\u202f290 hospitalized patients treated for CAP, 2079 (12.0%) met criteria for inappropriate diagnosis (median [IQR] age, 71.8 [60.1-82.8] years; 1045 [50.3%] female), of whom 1821 (87.6%) received full antibiotic courses. Compared with patients with CAP, patients inappropriately diagnosed were older (adjusted odds ratio [AOR], 1.08; 95% CI, 1.05-1.11 per decade) and more likely to have dementia (AOR, 1.79; 95% CI, 1.55-2.08) or altered mental status on presentation (AOR, 1.75; 95% CI, 1.39-2.19). Among those inappropriately diagnosed, 30-day composite outcomes for full vs brief treatment did not differ (25.8% vs 25.6%; AOR, 0.98; 95% CI, 0.79-1.23). Full vs brief duration of antibiotic treatment among patients was associated with antibiotic-associated adverse events (31 of 1821 [2.1%] vs 1 of 258 [0.4%];\u00a0P<\/em>\u2009=\u2009.03).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  In this cohort study, inappropriate diagnosis of CAP among hospitalized adults was common, particularly among older adults, those with dementia, and those presenting with altered mental status. Full-course antibiotic treatment of those inappropriately diagnosed with CAP may be harmful.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  March 25, 2024 I […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25799"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25799"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25799\/revisions"}],"predecessor-version":[{"id":25983,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25799\/revisions\/25983"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25799"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25799"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}