{"id":25668,"date":"2024-05-04T04:52:00","date_gmt":"2024-05-03T20:52:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=25668"},"modified":"2024-05-04T06:00:22","modified_gmt":"2024-05-03T22:00:22","slug":"chest%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%ae%9e%e4%bd%93%e5%99%a8%e5%ae%98%e7%a7%bb%e6%a4%8d%e5%8f%97%e4%bd%93%e7%9a%84%e5%86%9b%e5%9b%a2%e8%8f%8c%e7%97%85","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=25668","title":{"rendered":"[Chest\u53d1\u8868\u8bba\u6587]\uff1a\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u53d7\u4f53\u7684\u519b\u56e2\u83cc\u75c5"},"content":{"rendered":"\n

Chest Infections: Original Research<\/p>\n\n\n\n

Legionnaires Disease in Solid Organ Transplant Recipients: A Decade-Long Nationwide Study in France<\/h1>\n\n\n\n

Guillaume\u00a0Thizy,\u00a0Adrien\u00a0Flahault,\u00a0Anne\u00a0Scemla, et al<\/h3>\n\n\n\n

Chest 2024; 165: 507-520<\/h3>\n\n\n\n

https:\/\/doi.org\/10.1016\/j.chest.2023.09.033<\/a><\/h3>\n\n\n\n

Background<\/h3>\n\n\n\n

Legionnaires disease (LD) is a rare, life-threatening opportunistic bacterial infection that poses a significant risk to patients with impaired cell-mediated immunity such as solid organ transplant recipients. However, the epidemiologic features, clinical presentation, and outcomes of LD in this population are poorly described.<\/p>\n\n\n\n

Research Question<\/h3>\n\n\n\n

What are the clinical manifestations, radiologic presentation, risk factors for severity, treatment, and outcome of LD in solid organ transplant recipients?<\/p>\n\n\n\n

Study Design and Methods<\/h3>\n\n\n\n

In this 10-year multicenter retrospective cohort study in France, where LD notification is mandatory, patients were identified by hospital discharge databases. Diagnosis of LD relied on positive culture findings from any respiratory sample, positive urinary antigen test (UAT) results, positive specific serologic findings, or a combination thereof. Severe LD was defined as admission to the ICU.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

One hundred one patients from 51 transplantation centers were eligible; 64 patients (63.4%) were kidney transplant recipients. Median time between transplantation and LD was 5.6 years (interquartile range, 1.5-12 years). UAT results were positive in 92%\u00a0of patients (89\/97). Among 31 patients with positive culture findings in respiratory samples,\u00a0Legionella pneumophila<\/em>\u00a0serogroup 1 was identified in 90%. Chest CT imaging showed alveolar consolidation in 98%\u00a0of patients (54 of 57), ground-glass opacity in 63%\u00a0of patients (36 of 57), macronodules in 21%\u00a0of patients (12 of 57), and cavitation in 8.8%\u00a0of patients (5 of 57). Fifty-seven patients (56%) were hospitalized in the ICU. In multivariate analysis, severe LD was associated with negative UAT findings at presentation (P<\/em>\u00a0= .047), lymphopenia (P<\/em>\u00a0= .014), respiratory symptoms (P<\/em>\u00a0= .010), and pleural effusion (P<\/em>\u00a0= .039). The 30-day and 12-month mortality rates were 8%\u00a0(8 of 101) and 20%\u00a0(19 of 97), respectively. In multivariate analysis, diabetes mellitus was the only factor associated with 12-month mortality (hazard ratio, 3.2; 95%\u00a0OR, 1.19-8.64;\u00a0P<\/em>\u00a0= .022).<\/p>\n\n\n\n

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Interpretation<\/h3>\n\n\n\n

LD is a late and severe complication occurring in solid organ transplant recipients that may present as pulmonary nodules on which diabetes impacts its long-term prognosis.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chest Infections: Original Research Legionnaires Diseas […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25668"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25668"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25668\/revisions"}],"predecessor-version":[{"id":25669,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25668\/revisions\/25669"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25668"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25668"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25668"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}