{"id":25371,"date":"2024-02-26T04:39:00","date_gmt":"2024-02-25T20:39:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=25371"},"modified":"2024-02-26T05:38:28","modified_gmt":"2024-02-25T21:38:28","slug":"lancet%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e7%96%ab%e8%8b%97%e6%8e%a5%e7%a7%8d%e4%b8%8e%e9%87%8d%e7%97%87%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e7%bb%93%e5%b1%80","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=25371","title":{"rendered":"[Lancet\u53d1\u8868\u8bba\u6587]\uff1a\u75ab\u82d7\u63a5\u79cd\u4e0e\u91cd\u75c7\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7ed3\u5c40"},"content":{"rendered":"\n

ARTICLES|ONLINE FIRST<\/a><\/p>\n\n\n\n

Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales<\/h1>\n\n\n\n

The HDR UK COALESCE Consortium<\/h3>\n\n\n\n

Lancet Published:January 15, 2024<\/h3>\n\n\n\n

DOI:https:\/\/doi.org\/10.1016\/S0140-6736(23)02467-4<\/a><\/h3>\n\n\n\n

Summary<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

Undervaccination (receiving fewer than the recommended number of SARS-CoV-2 vaccine doses) could be associated with increased risk of severe COVID-19 outcomes\u2014ie, COVID-19 hospitalisation or death\u2014compared with full vaccination (receiving the recommended number of SARS-CoV-2 vaccine doses). We sought to determine the factors associated with undervaccination, and to investigate the risk of severe COVID-19 outcomes in people who were undervaccinated in each UK nation and across the UK.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

We used anonymised, harmonised electronic health record data with whole population coverage to carry out cohort studies in England, Northern Ireland, Scotland, and Wales. Participants were required to be at least 5 years of age to be included in the cohorts. We estimated adjusted odds ratios for undervaccination as of June 1, 2022. We also estimated adjusted hazard ratios (aHRs) for severe COVID-19 outcomes during the period June 1 to Sept 30, 2022, with undervaccination as a time-dependent exposure. We combined results from nation-specific analyses in a UK-wide fixed-effect meta-analysis. We estimated the reduction in severe COVID-19 outcomes associated with a counterfactual scenario in which everyone in the UK was fully vaccinated on June 1, 2022.<\/p>\n\n\n\n

Findings<\/h3>\n\n\n\n

The numbers of people undervaccinated on June 1, 2022 were 26\u2005985\u2005570 (45\u00b78%) of 58\u2005967\u2005360 in England, 938\u2005420 (49\u00b78%) of 1\u2005885\u2005670 in Northern Ireland, 1\u2005709\u2005786 (34\u00b72%) of 4\u2005992\u2005498 in Scotland, and 773\u2005850 (32\u00b78%) of 2\u2005358\u2005740 in Wales. People who were younger, from more deprived backgrounds, of non-White ethnicity, or had a lower number of comorbidities were less likely to be fully vaccinated. There was a total of 40\u2005393 severe COVID-19 outcomes in the cohorts, with 14\u2005156 of these in undervaccinated participants. We estimated the reduction in severe COVID-19 outcomes in the UK over 4 months of follow-up associated with a counterfactual scenario in which everyone was fully vaccinated on June 1, 2022 as 210 (95% CI 94\u2013326) in the 5\u201315 years age group, 1544 (1399\u20131689) in those aged 16\u201374 years, and 5426 (5340\u20135512) in those aged 75 years or older. aHRs for severe COVID-19 outcomes in the meta-analysis for the age group of 75 years or older were 2\u00b770 (2\u00b761\u20132\u00b778) for one dose fewer than recommended, 3\u00b713 (2\u00b793\u20133\u00b734) for two fewer, 3\u00b761 (3\u00b713\u20134\u00b717) for three fewer, and 3\u00b708 (2\u00b789\u20133\u00b729) for four fewer.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Interpretation<\/h3>\n\n\n\n

Rates of undervaccination against COVID-19 ranged from 32\u00b78% to 49\u00b78% across the four UK nations in summer, 2022. Undervaccination was associated with an elevated risk of severe COVID-19 outcomes.<\/p>\n\n\n\n

Funding<\/h3>\n\n\n\n

UK Research and Innovation National Core Studies: Data and Connectivity.<\/p>\n","protected":false},"excerpt":{"rendered":"

ARTICLES|ONLINE FIRST Undervaccination and severe COVID […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25371"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25371"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25371\/revisions"}],"predecessor-version":[{"id":25372,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25371\/revisions\/25372"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25371"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25371"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}