{"id":25292,"date":"2024-02-08T04:59:00","date_gmt":"2024-02-07T20:59:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=25292"},"modified":"2024-02-08T05:52:08","modified_gmt":"2024-02-07T21:52:08","slug":"intensive-care-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%89%8b%e6%9c%af%e7%9b%b8%e5%85%b3%e6%80%a5%e6%80%a7%e8%82%be%e6%8d%9f%e4%bc%a4%e7%9a%84%e6%b5%81%e8%a1%8c%e7%97%85%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=25292","title":{"rendered":"[Intensive Care Med\u53d1\u8868\u8bba\u6587]\uff1a\u624b\u672f\u76f8\u5173\u6025\u6027\u80be\u635f\u4f24\u7684\u6d41\u884c\u75c5\u5b66"},"content":{"rendered":"\n

Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study<\/h1>\n\n\n\n

Zarbock, A., Weiss, R., Albert, F.\u00a0et al.<\/em><\/h3>\n\n\n\n

Intensive Care Med<\/em>\u00a049<\/strong>, 1441\u20131455 (2023)<\/h3>\n\n\n\n

https:\/\/doi.org\/10.1007\/s00134-023-07169-7<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Purpose<\/h3>\n\n\n\n

The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries and health care systems is unclear.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

We conducted an international prospective, observational, multi-center study in 30 countries in patients undergoing major surgery (>\u20092-h duration and postoperative intensive care unit (ICU) or high dependency unit admission). The primary endpoint was the occurrence of PO-AKI within 72 h of surgery defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Secondary endpoints included PO-AKI severity and duration, use of renal replacement therapy (RRT), mortality, and ICU and hospital length of stay.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

We studied 10,568 patients and 1945 (18.4%) developed PO-AKI (1236 (63.5%) KDIGO stage 1500 (25.7%) KDIGO stage 2209 (10.7%) KDIGO stage 3). In 33.8% PO-AKI was persistent, and 170\/1945 (8.7%) of patients with PO-AKI received RRT in the ICU. Patients with PO-AKI had greater ICU (6.3% vs. 0.7%) and hospital (8.6% vs. 1.4%) mortality, and longer ICU (median 2 (Q1-Q3, 1\u20133) days vs. 3 (Q1-Q3, 1\u20136) days) and hospital length of stay (median 14 (Q1-Q3, 9\u201324) days vs. 10 (Q1-Q3, 7\u201317) days). Risk factors for PO-AKI included older age, comorbidities (hypertension, diabetes, chronic kidney disease), type, duration and urgency of surgery as well as intraoperative vasopressors, and aminoglycosides administration.<\/p>\n\n\n\n

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Conclusion<\/h3>\n\n\n\n

In a comprehensive multinational study, approximately one in five patients develop PO-AKI after major surgery. Increasing severity of PO-AKI is associated with a progressive increase in adverse outcomes. Our findings indicate that PO-AKI represents a significant burden for health care worldwide.<\/p>\n","protected":false},"excerpt":{"rendered":"

Epidemiology of surgery associated acute kidney injury […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25292"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25292"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25292\/revisions"}],"predecessor-version":[{"id":25293,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25292\/revisions\/25293"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}