{"id":25288,"date":"2024-02-07T04:39:00","date_gmt":"2024-02-06T20:39:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=25288"},"modified":"2024-02-07T05:27:40","modified_gmt":"2024-02-06T21:27:40","slug":"blue-journal%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%a4%a7%e5%89%82%e9%87%8f%e5%90%b8%e5%85%a5no%e6%b2%bb%e7%96%97%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e5%af%bc%e8%87%b4","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=25288","title":{"rendered":"[Blue Journal\u53d1\u8868\u8bba\u6587]\uff1a\u5927\u5242\u91cf\u5438\u5165NO\u6cbb\u7597\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u5bfc\u81f4\u7684\u6025\u6027\u4f4e\u6c27\u6027\u547c\u5438\u529f\u80fd\u8870\u7aed"},"content":{"rendered":"\n

High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial<\/h1>\n\n\n\n

<\/a>Raffaele Di Fenza,\u00a0\u00a0Naman S. Shetty,\u00a0\u00a0<\/a>Stefano Gianni,\u00a0et al<\/h3>\n\n\n\n

Am J Respir Crit Care Med 2023; 208: 1293-1304<\/h3>\n\n\n\n

Abstract<\/p>\n\n\n\n

Rationale:<\/strong> The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown.<\/p>\n\n\n\n

Objectives:<\/strong> The primary outcome was the change in arterial oxygenation (PaO2<\/sub>\/FiO2<\/sub>) at 48 hours. The secondary outcomes included: time to reach a PaO2<\/sub>\/FiO2<\/sub>.300mmHg for at least 24 hours, the proportion of participants with a PaO2<\/sub>\/FiO2<\/sub>.300mmHg at 28 days, and survival at 28 and at 90 days.<\/p>\n\n\n\n

Methods:<\/strong> Mechanically ventilated adults with COVID-19 pneumonia were enrolled in a phase II, multicenter, single-blind, randomized controlled parallel-arm trial. Participants in the intervention arm received inhaled nitric oxide at 80 ppm for 48 hours, compared with the control group receiving usual care (without placebo).<\/p>\n\n\n\n

Measurements and Main Results:<\/strong>\u00a0A total of 193 participants were included in the modified intention-to-treat analysis. The mean change in PaO2<\/sub>\/FiO2<\/sub>\u00a0ratio at 48 hours was 28.3mmHg in the intervention group and 21.4mmHg in the control group (mean difference, 39.1mmHg; 95% credible interval [CrI], 18.1 to 60.3). The mean time to reach a PaO2<\/sub>\/FiO2<\/sub>.300mmHg in the interventional group was 8.7 days, compared with 8.4 days for the control group (mean difference, 0.44; 95% CrI, 23.63 to 4.53). At 28 days, the proportion of participants attaining a PaO2<\/sub>\/FiO2<\/sub>.300mmHg was 27.7% in the inhaled nitric oxide group and 17.2% in the control subjects (risk ratio, 2.03; 95% CrI, 1.11 to 3.86). Duration of ventilation and mortality at 28 and 90 days did not differ. No serious adverse events were reported.<\/p>\n\n\n\n

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Conclusions:<\/strong> The use of high-dose inhaled nitric oxide resulted in an improvement of PaO2<\/sub>\/FiO2<\/sub> at 48 hours compared with usual care in adults with acute hypoxemic respiratory failure due to COVID-19.<\/p>\n","protected":false},"excerpt":{"rendered":"

High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respi […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25288"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25288"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25288\/revisions"}],"predecessor-version":[{"id":25289,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/25288\/revisions\/25289"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}