{"id":24718,"date":"2023-11-27T04:25:00","date_gmt":"2023-11-26T20:25:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=24718"},"modified":"2023-11-27T05:38:41","modified_gmt":"2023-11-26T21:38:41","slug":"cid%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%97%a2%e5%be%80%e8%87%aa%e8%ba%ab%e5%85%8d%e7%96%ab%e7%96%be%e7%97%85%e4%bc%b4%e9%9a%8f%e6%9b%b4%e4%b8%ba%e4%b8%a5%e9%87%8d%e7%9a%84%e6%96%b0","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=24718","title":{"rendered":"[CID\u53d1\u8868\u8bba\u6587]\uff1a\u65e2\u5f80\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u4f34\u968f\u66f4\u4e3a\u4e25\u91cd\u7684\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3"},"content":{"rendered":"\n

JOURNAL ARTICLE<\/p>\n\n\n\n

Preexisting Autoimmunity Is Associated With Increased Severity of Coronavirus Disease 2019: A Retrospective Cohort Study Using Data From the National COVID Cohort Collaborative (N3C) <\/h1>\n\n\n\n

Arjun S Yadaw,\u00a0\u00a0David K Sahner,\u00a0\u00a0Hythem Sidky,\u00a0\u00a0et al<\/h3>\n\n\n\n

Clinical Infectious Diseases<\/em>, Volume 77, Issue 6, 15 September 2023, Pages 816\u2013826<\/h3>\n\n\n\n

https:\/\/doi.org\/10.1093\/cid\/ciad294<\/a><\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/p>\n\n\n\n

Identifying individuals with a higher risk of developing severe coronavirus disease 2019 (COVID-19) outcomes will inform targeted and more intensive clinical monitoring and management. To date, there is mixed evidence regarding the impact of preexisting autoimmune disease (AID) diagnosis and\/or immunosuppressant (IS) exposure on developing severe COVID-19 outcomes.<\/p>\n\n\n\n

Methods<\/p>\n\n\n\n

A retrospective cohort of adults diagnosed with COVID-19 was created in the National COVID Cohort Collaborative enclave. Two outcomes, life-threatening disease and hospitalization, were evaluated by using logistic regression models with and without adjustment for demographics and comorbidities.<\/p>\n\n\n\n

Results<\/p>\n\n\n\n

Of the 2 453 799 adults diagnosed with COVID-19, 191 520 (7.81%) had a preexisting AID diagnosis and 278 095 (11.33%) had a preexisting IS exposure. Logistic regression models adjusted for demographics and comorbidities demonstrated that individuals with a preexisting AID (odds ratio [OR], 1.13; 95% confidence interval [CI]: 1.09\u20131.17;\u00a0P<\/em>\u00a0< .001), IS exposure (OR, 1.27; 95% CI: 1.24\u20131.30;\u00a0P<\/em>\u00a0< .001), or both (OR, 1.35; 95% CI: 1.29\u20131.40;\u00a0P<\/em>\u00a0< .001) were more likely to have a life-threatening disease. These results were consistent when hospitalization was evaluated. A sensitivity analysis evaluating specific IS revealed that tumor necrosis factor inhibitors were protective against life-threatening disease (OR, 0.80; 95% CI: .66\u2013.96;\u00a0P<\/em>\u00a0= .017) and hospitalization (OR, 0.80; 95% CI: .73\u2013.89;\u00a0P<\/em>\u00a0< .001).<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Conclusions<\/p>\n\n\n\n

Patients with preexisting AID, IS exposure, or both are more likely to have a life-threatening disease or hospitalization. These patients may thus require tailored monitoring and preventative measures to minimize negative consequences of COVID-19.<\/p>\n","protected":false},"excerpt":{"rendered":"

JOURNAL ARTICLE Preexisting Autoimmunity Is Associated […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24718"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24718"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24718\/revisions"}],"predecessor-version":[{"id":24719,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24718\/revisions\/24719"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}