{"id":24674,"date":"2023-10-23T04:41:00","date_gmt":"2023-10-22T20:41:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=24674"},"modified":"2023-10-23T06:09:38","modified_gmt":"2023-10-22T22:09:38","slug":"chest%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e9%99%8d%e9%92%99%e7%b4%a0%e5%8e%9f%e6%8c%87%e5%af%bc%e7%9a%84%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e6%82%a3%e8%80%85%e6%8a%97","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=24674","title":{"rendered":"[Chest\u53d1\u8868\u8bba\u6587]\uff1a\u964d\u9499\u7d20\u539f\u6307\u5bfc\u7684\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u60a3\u8005\u6297\u751f\u7d20\u5904\u65b9"},"content":{"rendered":"\n

CHEST INFECTIONS: ORIGINAL RESEARCH|\u00a0VOLUME 164, ISSUE 3<\/a>,\u00a0P596-605,\u00a0SEPTEMBER 2023<\/p>\n\n\n\n

Procalcitonin-Guided Antibiotic Prescription in Patients With COVID-19: A Multicenter Observational Cohort Study<\/h1>\n\n\n\n

Lisa M. Hessels, Esther Speksnijder, Nienke Paternotte, et al<\/h3>\n\n\n\n

Chest 2023; 164: 596-605 Published:April 26, 2023<\/h3>\n\n\n\n

DOI:https:\/\/doi.org\/10.1016\/j.chest.2023.04.032<\/a><\/h3>\n\n\n\n

Background<\/h3>\n\n\n\n

Despite the low rate of bacterial coinfection, antibiotics are very commonly prescribed in hospitalized patients with COVID-19.<\/p>\n\n\n\n

Research Question<\/h3>\n\n\n\n

Does the use of a procalcitonin (PCT)-guided antibiotic protocol safely reduce the use of antibiotics in patients with a COVID-19 infection?<\/p>\n\n\n\n

Study Design and Methods<\/h3>\n\n\n\n

In this multicenter cohort, three groups of patients with COVID-19 were compared in terms of antibiotic consumption, namely one group treated based on a PCT-algorithm in one hospital (n = 216) and two control groups, consisting of patients from the same hospital (n = 57) and of patients from three similar hospitals (n = 486) without PCT measurements during the same period. The primary end point was antibiotic prescription in the first week of admission.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

Antibiotic prescription during the first 7\u00a0days was 26.8%\u00a0in the PCT group, 43.9%\u00a0in the non-PCT group in the same hospital, and 44.7%\u00a0in the non-PCT group in other hospitals. Patients in the PCT group had lower odds of receiving antibiotics in the first 7\u00a0days of admission (OR, 0.33; 95%\u00a0CI, 0.16-0.66 compared with the same hospital; OR, 0.42; 95%\u00a0CI, 0.28-0.62 compared with the other hospitals). The proportion of patients receiving antibiotic prescription during the total admission was 35.2%, 43.9%, and 54.5%, respectively. The PCT group had lower odds of receiving antibiotics during the total admission only when compared with the other hospitals (OR, 0.23; 95%\u00a0CI, 0.08-0.63). There were no significant differences in other secondary end points, except for readmission in the PCT group vs\u00a0the other hospitals group.<\/p>\n\n\n\n

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Interpretation<\/h3>\n\n\n\n

PCT-guided antibiotic prescription reduces antibiotic prescription rates in hospitalized patients with COVID-19, without major safety concerns.<\/p>\n","protected":false},"excerpt":{"rendered":"

CHEST INFECTIONS: ORIGINAL RESEARCH|\u00a0VOLUME 164, ISSUE […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24674"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24674"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24674\/revisions"}],"predecessor-version":[{"id":24675,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24674\/revisions\/24675"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}