{"id":24498,"date":"2023-10-12T04:03:00","date_gmt":"2023-10-11T20:03:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=24498"},"modified":"2023-10-12T05:47:08","modified_gmt":"2023-10-11T21:47:08","slug":"lancet-infect-dis%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e8%8b%b1%e6%a0%bc%e5%85%b0%e6%b5%81%e6%84%9f%e5%97%9c%e8%a1%80%e6%9d%86%e8%8f%8c%e8%a1%80%e6%b8%85%e5%9e%8ba%e4%be%b5%e8%a2%ad%e6%80%a7","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=24498","title":{"rendered":"[Lancet Infect Dis\u53d1\u8868\u8bba\u6587]\uff1a\u82f1\u683c\u5170\u6d41\u611f\u55dc\u8840\u6746\u83cc\u8840\u6e05\u578bA\u4fb5\u88ad\u6027\u75be\u75c5\u7684\u8d8b\u52bf"},"content":{"rendered":"\n

ARTICLES|ONLINE FIRST<\/a><\/p>\n\n\n\n

Trends in invasive Haemophilus influenzae<\/em> serotype a disease in England from 2008\u201309 to 2021\u201322: a prospective national surveillance study<\/h1>\n\n\n\n

Marta Bertran, Joshua C D'Aeth, Erjola Hani, et al<\/h3>\n\n\n\n

Lancet Infect Dis Published:June 22, 2023DOI:https:\/\/doi.org\/10.1016\/S1473-3099(23)00188-3<\/a><\/h3>\n\n\n\n

Summary<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

Invasive Haemophilus influenzae<\/em> serotype a (Hia) disease is rare, with most cases reported among Indigenous populations in North America. In England, national surveillance was enhanced following an increase in laboratory-confirmed invasive Hia disease since the 2016\u201317 epidemiological year. This study aimed to describe the epidemiological trends, clinical characteristics of cases, and assess potential genomic drivers.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

Hospital laboratories in England routinely submit invasive H influenzae<\/em> isolates to the UK Health Security Agency for confirmation and serotyping. In this prospective national surveillance study we contacted the general practitioners and clinicians of all patients with laboratory-confirmed invasive Hia from the 2008\u201309 to the 2021\u201322 epidemiological year to complete a clinical questionnaire on demographics, underlying conditions, clinical presentation, complications, outcomes, and travel history of the patient. All Hia invasive isolates from residents in England were included in the study; non-invasive isolates were excluded. Multilocus sequence typing (MLST), whole genome single-nucleotide polymorphism, and k-mer-based analysis of bacterial isolates were performed following Illumina whole-genome sequencing (WGS). Outcomes included epidemiological trends, clinical characteristics of confirmed Hia cases, and genomic analyses.<\/p>\n\n\n\n

Findings<\/h3>\n\n\n\n

From the 2008\u201309 to the 2021\u201322 epidemiological years, there were 52 cases of invasive infection with\u00a0H influenzae<\/em>\u00a0serotype a in England (25 [48%] in female patients and 27 [52%] in male patients). There were zero to two annual Hia cases (accounting for <0\u00b75% of serotyped\u00a0H influenzae<\/em>\u00a0isolates) until 2015\u201316, after which cases increased across England to 19 cases in 2021\u201322 (incidence 0\u00b703 cases per 100\u2009000), when Hia accounted for 19 (4%) of 484 serotyped\u00a0H influenzae<\/em>\u00a0isolates, 19 (19%) of 100 capsulated cases, and 37% (19 of 52) of all\u00a0H influenzae<\/em>\u00a0cases between 2008\u201309 and 2021\u201322. Most of the recent increase in cases occurred among individuals aged 65 years and older (17 [33%] of 52), who typically presented with bacteraemic pneumonia (13 [76%] of 17), and infants younger than 1 year, who had the highest incidence and were more likely to present with meningitis (five [50%] of ten). Overall case fatality rate was 7\u00b77% (95% CI 2\u00b71\u201319\u00b77; four of 52 patients). WGS found that closely related MLST sequence types ST1511 (20 [39%] of 51), ST23 (13 [25%] of 51), and ST56 (seven [14%] of 51) accounted for most cases, with no evidence of serotype b strains switching capsule to Hia. Duplication of the capsule operon, associated with more severe disease, was present in 32 (80%) of 40 of these sequence types. Analysis of the core and accessory genome content grouped most isolates into a single strain.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Interpretation<\/h3>\n\n\n\n

The persistent increase in invasive Hia cases across England and across all age groups suggests widespread transmission, consistent with reports from other European countries, and will require close monitoring.<\/p>\n\n\n\n

Funding<\/h3>\n\n\n\n

UK Health Security Agency.<\/p>\n","protected":false},"excerpt":{"rendered":"

ARTICLES|ONLINE FIRST Trends in invasive Haemophil […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24498"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24498"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24498\/revisions"}],"predecessor-version":[{"id":24500,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24498\/revisions\/24500"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}