{"id":24365,"date":"2023-08-10T04:23:00","date_gmt":"2023-08-09T20:23:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=24365"},"modified":"2023-08-10T06:37:50","modified_gmt":"2023-08-09T22:37:50","slug":"intensive-care-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%84%9f%e6%9f%93%e6%80%a7%e4%bc%91%e5%85%8b%e6%82%a3%e8%80%85%e9%99%90%e5%88%b6%e9%9d%99%e8%84%89%e6%b6%b2%e4%bd%93%e7%9a%84%e9%95%bf","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=24365","title":{"rendered":"[Intensive Care Med\u53d1\u8868\u8bba\u6587]\uff1a\u611f\u67d3\u6027\u4f11\u514b\u60a3\u8005\u9650\u5236\u9759\u8109\u6db2\u4f53\u7684\u957f\u671f\u6548\u679c"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock<\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">Maj\u2010Brit N\u00f8rregaard Kj\u00e6r, Tine Sylvest Meyhoff, Praleene Sivapalan, et al<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">Intensive Care Med\u00a02023 Jun 18.\u00a0doi: 10.1007\/s00134-023-07114-8.\u00a0Online ahead of print<\/h3>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p><strong>Purpose:&nbsp;<\/strong>To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy in Septic Shock in Intensive Care (CLASSIC) trial.<\/p>\n\n\n\n<p><strong>Methods:&nbsp;<\/strong>We conducted the pre-planned analyses of mortality, health-related quality of life (HRQoL) using EuroQol (EQ)-5D-5L index values and EQ visual analogue scale (VAS), and cognitive function using Mini Montreal Cognitive Assessment (Mini MoCA) test at 1 year. Deceased patients were assigned numerical zero for HRQoL as a state equal to death and zero for cognitive function outcomes as worst possible score, and we used multiple imputation for missing data on HRQoL and cognitive function.<\/p>\n\n\n\n<p><strong>Results:\u00a0<\/strong>Among 1554 randomized patients, we obtained 1-year data on mortality in 97.9% of patients, HRQoL in 91.3%, and cognitive function in 86.3%. One-year mortality was 385\/746 (51.3%) in the restrictive-fluid group versus 383\/767 (49.9%) in the standard-fluid group, absolute risk difference 1.5%-points [99% confidence interval (CI) - 4.8 to 7.8]. Mean differences were 0.00 (99% CI - 0.06 to 0.05) for EQ-5D-5L index values, - 0.65 for EQ VAS (- 5.40 to 4.08), and - 0.14 for Mini MoCA (- 1.59 to 1.14) for the restrictive-fluid group versus the standard-fluid group. The results for survivors only were similar in both groups.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs00134-023-07114-8\/MediaObjects\/134_2023_7114_Fig1_HTML.png?as=webp\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs00134-023-07114-8\/MediaObjects\/134_2023_7114_Fig2_HTML.png?as=webp\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs00134-023-07114-8\/MediaObjects\/134_2023_7114_Fig3_HTML.png?as=webp\" alt=\"\"\/><\/figure>\n\n\n\n<p><strong>Conclusions:&nbsp;<\/strong>Among adult ICU patients with septic shock, restrictive versus standard IV fluid therapy resulted in similar survival, HRQoL, and cognitive function at 1 year, but clinically important differences could not be ruled out.<\/p>\n\n\n\n<p><strong>Trial registration:&nbsp;<\/strong>ClinicalTrials.gov&nbsp;<a href=\"http:\/\/clinicaltrials.gov\/show\/NCT03668236\">NCT03668236<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Long-term effects of restriction of intravenous fluid i [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24365"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24365"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24365\/revisions"}],"predecessor-version":[{"id":24366,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24365\/revisions\/24366"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}