{"id":24065,"date":"2023-06-17T04:55:00","date_gmt":"2023-06-16T20:55:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=24065"},"modified":"2023-06-17T05:53:10","modified_gmt":"2023-06-16T21:53:10","slug":"jama%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e5%90%8e%e6%80%a5%e6%80%a7%e6%9c%9f%e7%9a%84%e5%90%8e%e9%81%97%e7%97%87%e5%ae%9a%e4%b9%89","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=24065","title":{"rendered":"[JAMA\u53d1\u8868\u8bba\u6587]\uff1a\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u540e\u6025\u6027\u671f\u7684\u540e\u9057\u75c7\u5b9a\u4e49"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

May 25, 2023<\/p>\n\n\n\n

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection<\/h1>\n\n\n\n

Tanayott\u00a0Thaweethai,\u00a0Sarah E.\u00a0Jolley,\u00a0Elizabeth W.\u00a0Karlson,\u00a0et al<\/h3>\n\n\n\n

JAMA.\u00a0<\/em>Published online May 25, 2023. doi:10.1001\/jama.2023.8823<\/h3>\n\n\n\n

Key Points<\/p>\n\n\n\n

Question<\/strong>  What symptoms are differentially present in SARS-CoV-2\u2013infected individuals 6 months or more after infection compared with uninfected individuals, and what symptom-based criteria can be used to identify postacute sequelae of SARS-CoV-2 infection (PASC) cases?<\/p>\n\n\n\n

Findings<\/strong>  In this analysis of data from 9764 participants in the RECOVER adult cohort, a prospective longitudinal cohort study, 37 symptoms across multiple pathophysiological domains were identified as present more often in SARS-CoV-2\u2013infected participants at 6 months or more after infection compared with uninfected participants. A preliminary rule for identifying PASC was derived based on a composite symptom score.<\/p>\n\n\n\n

Meaning<\/strong>  A framework for identifying PASC cases based on symptoms is a first step to defining PASC as a new condition. These findings require iterative refinement that further incorporates clinical features to arrive at actionable definitions of PASC.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection<\/em> (PASC), also known as long COVID<\/em>. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals.<\/p>\n\n\n\n

Objective<\/strong>  To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  Prospective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling.<\/p>\n\n\n\n

Exposure<\/strong>  SARS-CoV-2 infection.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  PASC and 44 participant-reported symptoms (with severity thresholds).<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0A total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic\/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%]) were PASC positive at 6 months.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Conclusions and Relevance<\/strong>  A definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  May 25, 2023 Dev […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24065"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24065"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24065\/revisions"}],"predecessor-version":[{"id":24069,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/24065\/revisions\/24069"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}