{"id":23502,"date":"2023-03-17T04:33:00","date_gmt":"2023-03-16T20:33:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=23502"},"modified":"2023-03-17T05:44:26","modified_gmt":"2023-03-16T21:44:26","slug":"jama%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e8%8d%af%e7%89%a9%e7%89%b9%e5%be%81%e4%b8%8e%e7%94%9f%e4%ba%a7%e5%8e%82%e5%ae%b6%e7%9b%b4%e6%8e%a5%e9%9d%a2%e5%90%91%e6%b6%88%e8%b4%b9%e8%80%85","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=23502","title":{"rendered":"[JAMA\u53d1\u8868\u8bba\u6587]\uff1a\u836f\u7269\u7279\u5f81\u4e0e\u751f\u4ea7\u5382\u5bb6\u76f4\u63a5\u9762\u5411\u6d88\u8d39\u8005\u7684\u5e7f\u544a\u8d39\u7528\u7684\u76f8\u5173\u6027"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

February 7, 2023<\/p>\n\n\n\n

Association Between Drug Characteristics and Manufacturer Spending on Direct-to-Consumer Advertising<\/h1>\n\n\n\n

Michael J.\u00a0DiStefano,\u00a0Jenny M.\u00a0Markell,\u00a0Caroline C.\u00a0Doherty,\u00a0et al<\/h3>\n\n\n\n

JAMA.\u00a0<\/em>2023;329(5):386-392. doi:10.1001\/jama.2022.23968<\/h3>\n\n\n\n

Key Points<\/p>\n\n\n\n

Question<\/strong>  What drug characteristics are associated with larger proportions of promotional spending allocated to direct-to-consumer advertising?<\/p>\n\n\n\n

Findings<\/strong>  In this exploratory cross-sectional study of 150 prescription drugs with the highest US sales in 2020, a higher proportion of promotional spending allocated to direct-to-consumer advertising was associated with drugs rated as having lower added clinical benefit than for those having higher added clinical benefit (absolute 14.3% increase in proportion) and with total drug sales (absolute 1.5% increase in proportion for every 10% increase in sales).<\/p>\n\n\n\n

Meaning<\/strong>  Lower added clinical benefit ratings and higher total drug sales were associated with higher spending on direct-to-consumer advertising as the share of the total; further research is needed to understand the implications of these findings.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Some drugs are heavily marketed through direct-to-consumer advertising.<\/p>\n\n\n\n

Objective<\/strong>  To identify drug characteristics associated with a greater share of promotional spending on advertising directly to consumers.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  Exploratory cross-sectional analysis of drug characteristics and promotional spending for the 150 top-selling branded prescription drugs in the US in 2020 as identified from IQVIA National Sales Perspectives data. Promotional spending data were provided by IQVIA ChannelDynamics.<\/p>\n\n\n\n

Exposures<\/strong>  Drug characteristics (total 2020 sales; total 2020 promotional spending; clinical benefit ratings; number of indications, off-label use; molecule type; nature of condition treated; administration type; generic availability; US Food and Drug Administration [FDA] approval year, World Health Organization anatomical therapeutic chemical classification; Medicare annual mean spending per beneficiary; percent sales attributable to the drug; market size; market competitiveness) assessed from health technology assessment agencies (France\u2019s Haute Autorit\u00e9 de Sant\u00e9 and Canada\u2019s Patented Medicine Prices Review Board) and drug data sources (Drugs@FDA, the FDA Purple Book, Lexicomp, Merative Marketscan Research Databases, and Medicare Spending by Drug data).<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  Proportion of total promotional spending allocated to direct-to-consumer-advertising for each drug.<\/p>\n\n\n\n

Results<\/strong>  The 2020 median proportion of promotional spending allocated to direct-to-consumer advertising was 13.5% (IQR, 1.96%-36.6%); median promotional spending, $20.9 million (IQR, $2.72-$131 million); and median total sales, $1.51 billion (IQR, $0.97-$2.26 billion). Of the 150 best-selling drugs, 16 were missing data and key covariates; therefore, the primary study sample comprised 134 drugs. After adjustment for multiple drug characteristics, the mean proportion of total promotional spending allocated to direct-to-consumer advertising for the remaining 134 drugs was an absolute 14.3% (95% CI, 1.43%-27.2%; P<\/em>\u2009=\u2009.03) higher for those with low added clinical benefit than for those with high added clinical benefit and an absolute 1.5% (95% CI, 0.44%-2.56%; P<\/em>\u2009=\u2009.005) higher for each 10% increase in total sales.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Conclusions and Relevance<\/strong>  Among top-selling US drugs in 2020, a rating of lower added benefit and higher total drug sales were associated with a higher proportion of manufacturer total promotional spending allocated to direct-to-consumer advertising. Further research is needed to understand the implications of these findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  February 7, 2023 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23502"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23502"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23502\/revisions"}],"predecessor-version":[{"id":23503,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23502\/revisions\/23503"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}