{"id":23209,"date":"2023-03-28T05:10:00","date_gmt":"2023-03-27T21:10:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=23209"},"modified":"2023-03-28T05:52:03","modified_gmt":"2023-03-27T21:52:03","slug":"icu-management-practice-%e8%84%93%e6%af%92%e7%97%87%e6%82%a3%e8%80%85%e7%9a%84%e5%85%a8%e5%9f%ba%e5%9b%a0%e7%bb%84%e5%85%b3%e8%81%94%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=23209","title":{"rendered":"[ICU Management & Practice]: \u8113\u6bd2\u75c7\u60a3\u8005\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76"},"content":{"rendered":"\n

Genome-Wide Association Study of Patients With Sepsis<\/h1>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Sepsis is a systemic inflammatory response to infections accompanied by organ dysfunction. Sepsis has a high mortality rate of about 30%. Approximately 189 cases of sepsis per 100,000 people are reported per year. Many genetic studies have identified gene variants associated with the development and outcomes of sepsis. <\/p>\n\n\n\n

In this study, the researchers conduct the first genome-wide association study of 28-day survival in ICU patients with sepsis. The study was conducted in two stages. The first stage included 687 sepsis patients of European ancestry from the GEN-SEP network and 7.5 million imputed variants, while the second stage focused on the prioritised genetic variants and included 2,063 ICU sepsis patients of European ancestry and 701 African-American patients from the MESSI study. A meta-analysis of the two stages was then conducted, along with whole-blood transcriptomic, functional annotations and sensitivity analyses on the identified genes and variants. <\/p>\n\n\n\n

Eleven independent variants were prioritised in the first stage. Ten of the 11 prioritised variants were followed up in the second stage. Three of these variants reached the genome-wide significance threshold, including a missense variant in SAMD9.<\/em> SAMD9<\/em> could play a critical role in the inflammatory response during tissue injury and apoptosis. Study authors hypothesise that SAMD9<\/em> upregulation could potentially activate T cells and produce the accumulation of macrophages, conferring protection against the systemic dysregulation that occurs during sepsis. <\/p>\n\n\n\n

The first genomic-wide association study of 28-day sepsis survival identified novel variants associated with reduced survival. However, more studies need to be performed with a larger sample size to better assess the genetic effects on sepsis survival and to validate these findings.<\/p>\n\n\n\n

Source: Critical Care<\/a><\/p>\n\n\n\n

Image Credit: iStock<\/p>\n\n\n\n

\u00ab\u00ab PSP for Early Diagnosis of Post-Operative Peritonitis, Intra-abdominal Infection, Sepsis<\/a><\/p>\n\n\n\n

Vingmed Symposium: Identification of Sepsis Up to 72 hrs in Advance \u2013 PSP, a New Biomarker of Sepsis \u00bb\u00bb<\/a><\/p>\n\n\n\n

References:<\/h4>\n\n\n\n

Hernandez-Beeftink T, Guillen-Guio B, Lorenzo-Salazar JM et al. (2022) A genome-wide association study of survival in patients with sepsis<\/a>. Crit Care. 26:341.<\/p>\n\n\n\n

Published on : Wed, 9 Nov 2022<\/p>\n","protected":false},"excerpt":{"rendered":"

Genome-Wide Association Study of Patients With Sepsis S […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[24,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23209"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23209"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23209\/revisions"}],"predecessor-version":[{"id":23210,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23209\/revisions\/23210"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23209"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}