{"id":23203,"date":"2023-02-28T04:14:00","date_gmt":"2023-02-27T20:14:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=23203"},"modified":"2023-02-28T07:17:42","modified_gmt":"2023-02-27T23:17:42","slug":"clin-infect-dis%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%88%90%e4%ba%ba%e5%a4%9a%e7%b3%bb%e7%bb%9f%e7%82%8e%e7%97%87%e7%bb%bc%e5%90%88%e5%be%81","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=23203","title":{"rendered":"[Clin Infect Dis\u53d1\u8868\u8bba\u6587]\uff1a\u6210\u4eba\u591a\u7cfb\u7edf\u708e\u75c7\u7efc\u5408\u5f81"},"content":{"rendered":"\n

Multisystem Inflammatory Syndrome in Adults: Case Finding Through Systematic Review of Electronic Medical Records <\/h1>\n\n\n\n

Michael Melgar,\u00a0\u00a0Julia Haston,\u00a0\u00a0Jennifer DeCuir,\u00a0\u00a0et al<\/h3>\n\n\n\n

Clinical Infectious Diseases<\/em>, Volume 75, Issue 11, 1 December 2022, Pages 1903\u20131911,\u00a0https:\/\/doi.org\/10.1093\/cid\/ciac303<\/a><\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/p>\n\n\n\n

Multisystem inflammatory syndrome in adults (MIS-A) is a severe condition temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.<\/p>\n\n\n\n

Methods<\/p>\n\n\n\n

In this retrospective cohort study, we applied the US Centers for Disease Control and Prevention (CDC) case definition to identify diagnosed and undiagnosed MIS-A cases among adults discharged during April 2020\u2013January 2021 from 4 Atlanta, Georgia hospitals affiliated with a single medical center. Non\u2013MIS-A coronavirus disease 2019 (COVID-19) hospitalizations were identified using International Classification of Diseases, Tenth Revision, Clinical Modification<\/em>encounter code U07.1. We calculated the ratio of MIS-A to COVID-19 hospitalizations, compared demographic characteristics of the 2 cohorts, and described clinical characteristics of MIS-A patients.<\/p>\n\n\n\n

Results<\/p>\n\n\n\n

We identified 11 MIS-A cases, none of which were diagnosed by the treatment team, and 5755 COVID-19 hospitalizations (ratio 1:523). Compared with patients with COVID-19, patients with MIS-A were more likely to be younger than 50 years (72.7% vs 26.1%, P<\/em> < .01) and to be non-Hispanic Black (81.8% vs 50.0%, P<\/em> = .04). Ten patients with MIS-A (90.9%) had at least 1 underlying medical condition. Two MIS-A patients (18.2%) had a previous episode of laboratory-confirmed COVID-19, occurring 37 and 55 days prior to admission. All MIS-A patients developed left ventricular systolic dysfunction. None had documented mucocutaneous involvement. All required intensive care, all received systemic corticosteroids, 8 (72.7%) required mechanical ventilation, 2 (18.2%) required mechanical cardiovascular circulatory support, and none received intravenous immunoglobulin. Two (18.2%) died or were discharged to hospice.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

Conclusions<\/p>\n\n\n\n

MIS-A is a severe but likely underrecognized complication of SARS-CoV-2 infection. Improved recognition of MIS-A is needed to quantify its burden and identify populations at highest risk.<\/p>\n","protected":false},"excerpt":{"rendered":"

Multisystem Inflammatory Syndrome in Adults: Case Findi […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23203"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23203"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23203\/revisions"}],"predecessor-version":[{"id":23655,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23203\/revisions\/23655"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23203"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23203"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23203"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}