{"id":23201,"date":"2023-01-07T05:02:00","date_gmt":"2023-01-06T21:02:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=23201"},"modified":"2023-01-07T09:46:30","modified_gmt":"2023-01-07T01:46:30","slug":"clin-infect-dis%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e8%80%90beta%e5%86%85%e9%85%b0%e8%83%ba%e8%82%ba%e7%82%8e%e9%93%be%e7%90%83%e8%8f%8c%e6%b2%bb%e7%96%97%e5%90%8e%e7%9a%84%e5%8a%a8","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=23201","title":{"rendered":"[Clin Infect Dis\u53d1\u8868\u8bba\u6587]\uff1a\u8010Beta\u5185\u9170\u80fa\u80ba\u708e\u94fe\u7403\u83cc\u6cbb\u7597\u540e\u7684\u52a8\u529b\u5b66"},"content":{"rendered":"\n

\u03b2-Lactam\u2013Resistant\u00a0Streptococcus pneumoniae<\/em> Dynamics Following Treatment: A Dose-Response Meta-analysis\u00a0<\/h1>\n\n\n\n

Matas Griskaitis,\u00a0\u00a0Luis Furuya-Kanamori,\u00a0\u00a0Kasim Allel,\u00a0\u00a0et al<\/h3>\n\n\n\n

Clinical Infectious Diseases<\/em>, Volume 75, Issue 11, 1 December 2022, Pages 1962\u20131970,\u00a0https:\/\/doi.org\/10.1093\/cid\/ciac293<\/a><\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background<\/p>\n\n\n\n

Patient exposure to antibiotics promotes the emergence of drug-resistant pathogens. The aim of this study was to identify whether the temporal dynamics of resistance emergence at the individual-patient level were predictable for specific pathogen-drug classes.<\/p>\n\n\n\n

Methods<\/p>\n\n\n\n

Following a systematic review, a novel robust error meta-regression method for dose-response meta-analysis was used to estimate the odds ratio (OR) for carrying resistant bacteria during and following treatment compared to baseline. Probability density functions fitted to the resulting dose-response curves were then used to optimize the period during and\/or after treatment when resistant pathogens were most likely to be identified.<\/p>\n\n\n\n

Results<\/p>\n\n\n\n

Studies of Streptococcus pneumoniae<\/em> treatment with \u03b2-lactam antibiotics demonstrated a peak in resistance prevalence among patients 4 days after completing treatment with a 3.32-fold increase in odds (95% confidence interval [CI], 1.71\u20136.46). Resistance waned more gradually than it emerged, returning to preexposure levels 1 month after treatment (OR, 0.98 [95% CI, .55\u20131.75]). Patient isolation during the peak dose-response period would be expected to reduce the risk that a transmitted pathogen is resistant equivalently to a 50% longer isolation window timed from the first day of treatment.<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
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Conclusions<\/p>\n\n\n\n

Predictable temporal dynamics of resistance levels have implications both for surveillance and control.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u03b2-Lactam\u2013Resistant\u00a0Streptococcus pneumoniae Dynamics Fo […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23201"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23201"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23201\/revisions"}],"predecessor-version":[{"id":23354,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/23201\/revisions\/23354"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=23201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=23201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}