{"id":22600,"date":"2022-10-07T04:47:00","date_gmt":"2022-10-06T20:47:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=22600"},"modified":"2022-10-07T07:15:54","modified_gmt":"2022-10-06T23:15:54","slug":"bmj%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87-%e9%87%87%e7%94%a8%e6%a3%80%e6%b5%8b%e5%92%8c%e6%b2%bb%e7%96%97%e6%96%b9%e5%bc%8f%e8%a1%a5%e5%85%85%e7%bb%b4%e7%94%9f%e7%b4%a0d%e9%98%9f%e5%85%a8%e5%9b%a0","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=22600","title":{"rendered":"[BMJ\u53d1\u8868\u8bba\u6587]: \u91c7\u7528\u68c0\u6d4b\u548c\u6cbb\u7597\u65b9\u5f0f\u8865\u5145\u7ef4\u751f\u7d20D\u961f\u5168\u56e0\u6025\u6027\u547c\u5438\u9053\u611f\u67d3\u548c\u65b0\u51a0\u80ba\u708e\u7684\u5f71\u54cd"},"content":{"rendered":"\n

Research<\/strong><\/p>\n\n\n\n

Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT)<\/h1>\n\n\n\n

David A Jolliffe<\/a>, Hayley Holt, Matthew Greenig,\u00a0et al<\/h3>\n\n\n\n

BMJ<\/em>\u00a02022;\u00a0378\u00a0doi:\u00a0https:\/\/doi.org\/10.1136\/bmj-2022-071230<\/a>\u00a0(Published 07 September 2022)Cite this as:\u00a0BMJ<\/em>\u00a02022;378:e071230<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Objective<\/strong> To determine the effect of population level implementation of a test-and-treat approach to correction of suboptimal vitamin D status (25-hydroxyvitamin D (25(OH)D) <75 nmol\/L) on risk of all cause acute respiratory tract infection and covid 19.<\/p>\n\n\n\n

Design<\/strong> Phase 3 open label randomised controlled trial.<\/p>\n\n\n\n

Setting<\/strong> United Kingdom.<\/p>\n\n\n\n

Participants<\/strong> 6200 people aged \u226516 years who were not taking vitamin D supplements at baseline.<\/p>\n\n\n\n

Interventions<\/strong> Offer of a postal finger prick test of blood 25(OH)D concentration with provision of a six month supply of lower dose vitamin D (800 IU\/day, n=1550) or higher dose vitamin D (3200 IU\/day, n=1550) to those with blood 25(OH)D concentration <75 nmol\/L, compared with no offer of testing or supplementation (n=3100). Follow-up was for six months.<\/p>\n\n\n\n

Main outcome measures<\/strong> The primary outcome was the proportion of participants with at least one swab test or doctor confirmed acute respiratory tract infection of any cause. A secondary outcome was the proportion of participants with swab test confirmed covid-19. Logistic regression was used to calculate odds ratios and associated 95% confidence intervals. The primary analysis was conducted by intention to treat.<\/p>\n\n\n\n

Results<\/strong>\u00a0Of 3100 participants offered a vitamin D test, 2958 (95.4%) accepted and 2674 (86.3%) had 25(OH)D concentrations <75 nmol\/L and received vitamin D supplements (n=1328 lower dose, n=1346 higher dose). Compared with 136\/2949 (4.6%) participants in the no offer group, at least one acute respiratory tract infection of any cause occurred in 87\/1515 (5.7%) in the lower dose group (odds ratio 1.26, 95% confidence interval 0.96 to 1.66) and 76\/1515 (5.0%) in the higher dose group (1.09, 0.82 to 1.46). Compared with 78\/2949 (2.6%) participants in the no offer group, 55\/1515 (3.6%) developed covid-19 in the lower dose group (1.39, 0.98 to 1.97) and 45\/1515 (3.0%) in the higher dose group (1.13, 0.78 to 1.63).<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Conclusions<\/strong> Among people aged 16 years and older with a high baseline prevalence of suboptimal vitamin D status, implementation of a population level test-and-treat approach to vitamin D supplementation was not associated with a reduction in risk of all cause acute respiratory tract infection or covid-19.<\/p>\n\n\n\n

Trial registration<\/strong> ClinicalTrials.gov NCT04579640<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research Effect of a test-and-treat approach to vitamin […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/22600"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22600"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/22600\/revisions"}],"predecessor-version":[{"id":22601,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/22600\/revisions\/22601"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}