{"id":22595,"date":"2022-10-06T04:56:00","date_gmt":"2022-10-05T20:56:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=22595"},"modified":"2022-10-06T08:08:17","modified_gmt":"2022-10-06T00:08:17","slug":"jama%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%84%bf%e7%ab%a5%e5%92%8c%e9%9d%92%e5%b0%91%e5%b9%b4%e8%87%aa%e5%b7%b1%e9%87%87%e9%9b%86%e9%bc%bb%e6%8b%ad%e5%ad%90%e4%b8%8e%e5%8c%bb%e5%8a%a1","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=22595","title":{"rendered":"[JAMA\u53d1\u8868\u8bba\u6587]\uff1a\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u81ea\u5df1\u91c7\u96c6\u9f3b\u62ed\u5b50\u4e0e\u533b\u52a1\u4eba\u5458\u91c7\u6837\u65b0\u51a0\u75c5\u6bd2\u68c0\u6d4b\u7ed3\u679c\u7684\u4e00\u81f4\u6027"},"content":{"rendered":"\n

Original Investigation <\/p>\n\n\n\n

August 26, 2022<\/p>\n\n\n\n

Concordance of SARS-CoV-2 Results in Self-collected Nasal Swabs vs Swabs Collected by Health Care Workers in Children and Adolescents<\/h1>\n\n\n\n

Jesse J.\u00a0Waggoner,\u00a0Miriam B.\u00a0Vos,\u00a0Erika A.\u00a0Tyburski,\u00a0et al<\/h3>\n\n\n\n

JAMA.\u00a0<\/em>Published online August 26, 2022. doi:10.1001\/jama.2022.14877<\/h3>\n\n\n\n

Key Points<\/p>\n\n\n\n

Question<\/strong>  Are children and adolescents, aged 4 to 14 years, able to adequately self-collect nasal swabs for SARS-CoV-2 testing after hearing and seeing brief and age-appropriate instructions?<\/p>\n\n\n\n

Findings<\/strong>  In a cross-sectional study of 197 symptomatic children and adolescents, self-collected nasal swabs that were positive for SARS-CoV-2 agreed with results from health care worker\u2013collected swabs in 97.8% of participants, while self-collected swabs that were negative agreed with health care worker\u2013collected swabs in 98.1% of participants.<\/p>\n\n\n\n

Meaning<\/strong>  SARS-CoV-2 detection in nasal swabs that were self-collected by school-aged children and adolescents, following simple instructions, demonstrated high agreement with results following collection by health care workers.<\/a><\/p>\n\n\n\n

Abstract<\/p>\n\n\n\n

Importance<\/strong>  Despite the expansion of SARS-CoV-2 testing, available tests have not received Emergency Use Authorization for performance with self-collected anterior nares (nasal) swabs from children younger than 14 years because the effect of pediatric self-swabbing on SARS-CoV-2 test sensitivity is unknown.<\/p>\n\n\n\n

Objective<\/strong>  To characterize the ability of school-aged children to self-collect nasal swabs for SARS-CoV-2 testing compared with collection by health care workers.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  Cross-sectional study of 197 symptomatic children and adolescents aged 4 to 14 years old. Individuals were recruited based on results of testing in the Children\u2019s Healthcare of Atlanta system from July to August 2021.<\/p>\n\n\n\n

Exposures<\/strong>  Children and adolescents were given instructional material consisting of a short instructional video and a handout with written and visual steps for self-swab collection. Participants first provided a self-collected nasal swab. Health care workers then collected a second specimen.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was SARS-CoV-2 detection and relative quantitation by cycle threshold (Ct) in self- vs health care worker\u2013collected nasal swabs when tested with a real-time reverse transcriptase\u2013polymerase chain reaction test with Emergency Use Authorization.<\/p>\n\n\n\n

Results<\/strong>\u00a0\u00a0Among the study participants, 108 of 194 (55.7%) were male and the median age was 9 years (IQR, 6-11). Of the 196 participants, 87 (44.4%) tested positive for SARS-CoV-2 and 105 (53.6%) tested negative by both self- and health care worker\u2013collected swabs. Two children tested positive by self- or health care worker\u2013collected swab alone; 1 child had an invalid health care worker swab. Compared with health care worker\u2013collected swabs, self-collected swabs had 97.8% (95% CI, 94.7%-100.0%) and 98.1% (95% CI, 95.6%-100.0%) positive and negative percent agreement, respectively, and SARS-CoV-2 Ct values did not differ significantly between groups (mean [SD] Ct, self-swab: 26.7 [5.4] vs health care worker swab: 26.3 [6.0];\u00a0P<\/em>\u2009=\u2009.65).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  After hearing and seeing simple instructional materials, children and adolescents aged 4 to 14 years self-collected nasal swabs that closely agreed on SARS-CoV-2 detection with swabs collected by health care workers.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation  August 26, 2022 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/22595"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22595"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/22595\/revisions"}],"predecessor-version":[{"id":22596,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/22595\/revisions\/22596"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}