{"id":22056,"date":"2022-08-02T05:25:00","date_gmt":"2022-08-01T21:25:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=22056"},"modified":"2022-08-02T05:39:10","modified_gmt":"2022-08-01T21:39:10","slug":"lancet%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e7%be%8e%e5%9b%bd%e6%8e%a5%e7%a7%8d%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92mrna%e5%90%8e%e5%bf%83%e8%82%8c%e7%82%8e%e5%92%8c%e5%bf%83%e5%8c%85","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=22056","title":{"rendered":"[Lancet\u53d1\u8868\u8bba\u6587]\uff1a\u7f8e\u56fd\u63a5\u79cd\u65b0\u51a0\u75c5\u6bd2mRNA\u540e\u5fc3\u808c\u708e\u548c\u5fc3\u5305\u708e\u7684\u98ce\u9669"},"content":{"rendered":"\n

ARTICLES| VOLUME 399, ISSUE 10342<\/a>, P2191-2199, JUNE 11, 2022<\/p>\n\n\n\n

Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases<\/h1>\n\n\n\n

Hui-Lee Wong, Mao Hu, Cindy Ke Zhou,\u00a0et al<\/h3>\n\n\n\n

Lancet 2022; 399: 2191-2199<\/h3>\n\n\n\n

Summary<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

Several passive surveillance systems reported increased risks of myocarditis or pericarditis, or both, after COVID-19 mRNA vaccination, especially in young men. We used active surveillance from large health-care databases to quantify and enable the direct comparison of the risk of myocarditis or pericarditis, or both, after mRNA-1273 (Moderna) and BNT162b2 (Pfizer\u2013BioNTech) vaccinations.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

We conducted a retrospective cohort study, examining the primary outcome of myocarditis or pericarditis, or both, identified using the International Classification of Diseases diagnosis codes, occurring 1\u20137 days post-vaccination, evaluated in COVID-19 mRNA vaccinees aged 18\u201364 years using health plan claims databases in the USA. Observed (O) incidence rates were compared with expected (E) incidence rates estimated from historical cohorts by each database. We used multivariate Poisson regression to estimate the adjusted incidence rates, specific to each brand of vaccine, and incidence rate ratios (IRRs) comparing mRNA-1273 and BNT162b2. We used meta-analyses to pool the adjusted incidence rates and IRRs across databases.<\/p>\n\n\n\n

Findings<\/h3>\n\n\n\n

A total of 411 myocarditis or pericarditis, or both, events were observed among 15\u2008148\u2008369 people aged 18\u201364 years who received 16\u2008912\u2008716 doses of BNT162b2 and 10\u2008631\u2008554 doses of mRNA-1273. Among men aged 18\u201325 years, the pooled incidence rate was highest after the second dose, at 1\u00b771 (95% CI 1\u00b731 to 2\u00b723) per 100\u2008000 person-days for BNT162b2 and 2\u00b717 (1\u00b755 to 3\u00b704) per 100\u2008000 person-days for mRNA-1273. The pooled IRR in the head-to-head comparison of the two mRNA vaccines was 1\u00b743 (95% CI 0\u00b788 to 2\u00b734), with an excess risk of 27\u00b780 per million doses (\u201321\u00b788 to 77\u00b748) in mRNA-1273 recipients compared with BNT162b2.<\/p>\n\n\n\n

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Interpretation<\/h3>\n\n\n\n

An increased risk of myocarditis or pericarditis was observed after COVID-19 mRNA vaccination and was highest in men aged 18\u201325 years after a second dose of the vaccine. However, the incidence was rare. These results do not indicate a statistically significant risk difference between mRNA-1273 and BNT162b2, but it should not be ruled out that a difference might exist. Our study results, along with the benefit\u2013risk profile, continue to support vaccination using either of the two mRNA vaccines.<\/p>\n\n\n\n

Funding<\/h3>\n\n\n\n

US Food and Drug Administration.<\/p>\n","protected":false},"excerpt":{"rendered":"

ARTICLES| VOLUME 399, ISSUE 10342, P2191-2199 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/22056"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=22056"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/22056\/revisions"}],"predecessor-version":[{"id":22057,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/22056\/revisions\/22057"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=22056"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=22056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}