{"id":21933,"date":"2022-07-23T04:38:00","date_gmt":"2022-07-22T20:38:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21933"},"modified":"2022-07-23T07:50:06","modified_gmt":"2022-07-22T23:50:06","slug":"lancet-respir-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e8%8b%b1%e5%9b%bd%e6%96%b0%e5%86%a0%e8%82%ba%e7%82%8e%e6%82%a3%e8%80%85%e9%95%bf%e6%9c%9f%e5%90%8e%e9%81%97%e7%97%87%e7%82%8e%e7%97%87","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21933","title":{"rendered":"[Lancet Respir Med\u53d1\u8868\u8bba\u6587]\uff1a\u82f1\u56fd\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u957f\u671f\u540e\u9057\u75c7\u708e\u75c7\u53cd\u5e94\u7684\u4e34\u5e8a\u7279\u5f81\u53ca\u5176\u4e0e\u4f4f\u9662\u540e\u4e00\u5e74\u6062\u590d\u7684\u76f8\u5173\u6027"},"content":{"rendered":"\n

ARTICLES|ONLINE FIRST<\/a><\/p>\n\n\n\n

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study<\/h1>\n\n\n\n

The PHOSP-COVID Collaborative Group<\/h3>\n\n\n\n

Lancet Respir Med Published:April 23, 2022<\/h3>\n\n\n\n

DOI:https:\/\/doi.org\/10.1016\/S2213-2600(22)00127-8<\/a><\/h3>\n\n\n\n

Summary<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for COVID-19, identify factors associated with patient-perceived recovery, and identify potential therapeutic targets by describing the underlying inflammatory profiles of the previously described recovery clusters at 5 months after hospital discharge.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study recruiting adults (aged \u226518 years) discharged from hospital with COVID-19 across the UK. Recovery was assessed using patient-reported outcome measures, physical performance, and organ function at 5 months and 1 year after hospital discharge, and stratified by both patient-perceived recovery and recovery cluster. Hierarchical logistic regression modelling was performed for patient-perceived recovery at 1 year. Cluster analysis was done using the clustering large applications k-medoids approach using clinical outcomes at 5 months. Inflammatory protein profiling was analysed from plasma at the 5-month visit. This study is registered on the ISRCTN Registry, ISRCTN10980107, and recruitment is ongoing.<\/p>\n\n\n\n

Findings<\/h3>\n\n\n\n

2320 participants discharged from hospital between March 7, 2020, and April 18, 2021, were assessed at 5 months after discharge and 807 (32\u00b77%) participants completed both the 5-month and 1-year visits. 279 (35\u00b76%) of these 807 patients were women and 505 (64\u00b74%) were men, with a mean age of 58\u00b77 (SD 12\u00b75) years, and 224 (27\u00b78%) had received invasive mechanical ventilation (WHO class 7\u20139). The proportion of patients reporting full recovery was unchanged between 5 months (501 [25\u00b75%] of 1965) and 1 year (232 [28\u00b79%] of 804). Factors associated with being less likely to report full recovery at 1 year were female sex (odds ratio 0\u00b768 [95% CI 0\u00b746\u20130\u00b799]), obesity (0\u00b750 [0\u00b734\u20130\u00b774]) and invasive mechanical ventilation (0\u00b742 [0\u00b723\u20130\u00b776]). Cluster analysis (n=1636) corroborated the previously reported four clusters: very severe, severe, moderate with cognitive impairment, and mild, relating to the severity of physical health, mental health, and cognitive impairment at 5 months. We found increased inflammatory mediators of tissue damage and repair in both the very severe and the moderate with cognitive impairment clusters compared with the mild cluster, including IL-6 concentration, which was increased in both comparisons (n=626 participants). We found a substantial deficit in median EQ-5D-5L utility index from before COVID-19 (retrospective assessment; 0\u00b788 [IQR 0\u00b774\u20131\u00b700]), at 5 months (0\u00b774 [0\u00b764\u20130\u00b788]) to 1 year (0\u00b775 [0\u00b762\u20130\u00b788]), with minimal improvements across all outcome measures at 1 year after discharge in the whole cohort and within each of the four clusters.<\/p>\n\n\n\n

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Interpretation<\/h3>\n\n\n\n

The sequelae of a hospital admission with COVID-19 were substantial 1 year after discharge across a range of health domains, with the minority in our cohort feeling fully recovered. Patient-perceived health-related quality of life was reduced at 1 year compared with before hospital admission. Systematic inflammation and obesity are potential treatable traits that warrant further investigation in clinical trials.<\/p>\n\n\n\n

Funding<\/h3>\n\n\n\n

UK Research and Innovation and National Institute for Health Research.<\/p>\n","protected":false},"excerpt":{"rendered":"

ARTICLES|ONLINE FIRST Clinical characteristics with inf […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21933"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21933"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21933\/revisions"}],"predecessor-version":[{"id":21935,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21933\/revisions\/21935"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}