{"id":21909,"date":"2022-07-24T04:52:00","date_gmt":"2022-07-23T20:52:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21909"},"modified":"2022-07-24T05:46:00","modified_gmt":"2022-07-23T21:46:00","slug":"chest%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e9%98%bf%e5%8f%b8%e5%8c%b9%e6%9e%97%e6%b2%bb%e7%96%97ards","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21909","title":{"rendered":"[Chest\u53d1\u8868\u8bba\u6587]\uff1a\u963f\u53f8\u5339\u6797\u6cbb\u7597ARDS"},"content":{"rendered":"\n

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 5<\/a>, P1275-1284, MAY 01, 2022<\/p>\n\n\n\n

Aspirin as a Treatment for ARDS: A Randomized, Placebo-Controlled Clinical Trial<\/h1>\n\n\n\n

Philip Toner, Andrew J. Boyle, James J. McNamee, et al<\/h3>\n\n\n\n

Chest 2022; 161: 1275-1284<\/h3>\n\n\n\n

Background<\/h3>\n\n\n\n

There is no pharmacologic treatment for ARDS. Platelets play an important role in the pathophysiology of ARDS. Preclinical, observational, and clinically relevant models of ARDS indicate aspirin as a potential therapeutic option.<\/p>\n\n\n\n

Research Question<\/h3>\n\n\n\n

Is enteral aspirin (75 mg, once daily) safe and effective in improving surrogate outcomes in adult patients with ARDS?<\/p>\n\n\n\n

Study Design and Methods<\/h3>\n\n\n\n

This randomized, double-blind (patient and investigator), allocation-concealed, placebo-controlled phase 2 trial was conducted in five UK ICUs. Patients fulfilling the Berlin definition of ARDS were randomly assigned at a 1:1 ratio to receive enteral aspirin (75 mg) or placebo, for a maximum of 14 days, using a computer-generated randomization schedule, with variable block size, stratified by vasopressor requirement. The primary end point was oxygenation index (OI) on day 7. Secondary outcomes included safety parameters and other respiratory physiological markers. Analyses were by intention to treat.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

The trial was stopped early, due to slow recruitment, after 49 of a planned 60 patients were recruited. Twenty-four patients were allocated to aspirin and 25 to placebo. There was no significant difference in day 7 OI [aspirin group: unadjusted mean, 54.4 (SD 26.8); placebo group: 42.4 (SD 25); mean difference, 12.0; 95% CI, \u20136.1 to 30.1; P<\/em> = .19]. Aspirin did not significantly impact the secondary outcomes. There was no difference in the number of adverse events between the groups (13 in each; OR, 1.04; 95% CI, 0.56-1.94; P<\/em> = .56).<\/p>\n\n\n\n

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Interpretation<\/h3>\n\n\n\n

Aspirin was well tolerated but did not improve OI or other physiological outcomes; a larger trial is not feasible in its current design.<\/p>\n\n\n\n

Trial Registration<\/h3>\n\n\n\n

ClinicalTrials.gov<\/a>; No.: NCT02326350<\/a>; URL: www.clinicaltrials.gov<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSU […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21909"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21909"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21909\/revisions"}],"predecessor-version":[{"id":21910,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21909\/revisions\/21910"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}