{"id":21905,"date":"2022-07-07T04:39:00","date_gmt":"2022-07-06T20:39:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21905"},"modified":"2022-07-07T05:38:43","modified_gmt":"2022-07-06T21:38:43","slug":"blue-journal%e9%87%8d%e7%97%87%e5%bd%b1%e5%83%8f%ef%bc%9a%e6%9c%ba%e6%a2%b0%e9%80%9a%e6%b0%94%e6%96%b0%e5%86%a0%e8%82%ba%e7%82%8e%e6%82%a3%e8%80%85%e5%bf%ab%e9%80%9f%e8%b5%b7%e7%97%85%e7%9a%84","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21905","title":{"rendered":"[Blue Journal\u91cd\u75c7\u5f71\u50cf]\uff1a\u673a\u68b0\u901a\u6c14\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u5feb\u901f\u8d77\u75c5\u7684\u56ca\u6027\u652f\u6c14\u7ba1\u6269\u5f20"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Rapid-Onset Cystic Bronchiectasis in a Mechanically Ventilated Patient with COVID-19<\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">Michael Gilmartin\u00a0,\u00a0\u00a0Ahmad Basirat\u00a0,\u00a0\u00a0Conor Barry\u00a0,\u00a0et al<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">Am J Respir Crit Care Med Vol 205, Iss 6, pp 721\u2013722, Mar 15, 2022<\/h3>\n\n\n\n<p>A 40-year-old man presented to the ICU after intubation due to respiratory failure secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonitis. Past medical history revealed a history of intravenous drug use (heroin). Early blood and sputum cultures also grew a Panton-Valentine leukocidin\u2013positive\u00a0<em>Staphylococcus aureus<\/em>. Dexamethasone and antibiotics were administered and lung-protective ventilation and proning were instituted. Imaging during the first and second week of illness revealed rapid progression from pneumonitis to severe cystic bronchiectasis (<a href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.202103-0642IM#\">Figures 1<\/a>\u2013<a href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.202103-0642IM#\">3<\/a>). The patient developed persistent hypercapnic acidosis, despite high Ve. Bedside calculations revealed dead space ventilation ranging from 5.14 L\/min to 5.92 L\/min. The patient received a tracheostomy in his third week of stay to facilitate weaning of mechanical ventilation. After ICU discharge, he received rehabilitation for critical illness myopathy and developed a mild persistent productive cough. He was discharged to a step-down facility for ongoing rehabilitation 5 months after admission.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.atsjournals.org\/na101\/home\/literatum\/publisher\/thoracic\/journals\/content\/ajrccm\/2022\/ajrccm.2022.205.issue-6\/rccm.202103-0642im\/20220303\/images\/large\/rccm.202103-0642imf1.jpeg\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.atsjournals.org\/na101\/home\/literatum\/publisher\/thoracic\/journals\/content\/ajrccm\/2022\/ajrccm.2022.205.issue-6\/rccm.202103-0642im\/20220303\/images\/large\/rccm.202103-0642imf2.jpeg\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.atsjournals.org\/na101\/home\/literatum\/publisher\/thoracic\/journals\/content\/ajrccm\/2022\/ajrccm.2022.205.issue-6\/rccm.202103-0642im\/20220303\/images\/large\/rccm.202103-0642imf3.jpeg\" alt=\"\"\/><\/figure>\n\n\n\n<p>Bronchiectasis is characterized by abnormal bronchial wall thickening and luminal dilation due to a cycle of infection and inflammation (<a href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.202103-0642IM#\">1<\/a>). Its development is a known complication of severe respiratory infection and is a reported complication of SARS-CoV-2, found in up to 11% of cases (<a href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.202103-0642IM#\">2<\/a>\u2013<a href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.202103-0642IM#\">5<\/a>). The long-term sequelae of SARS-CoV-2 pneumonitis have yet to be fully elucidated. However, a number of authors have highlighted the potential for postinfective bronchiectasis to be an important issue (<a href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.202103-0642IM#\">6<\/a>,\u00a0<a href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.202103-0642IM#\">7<\/a>). This case is unusual for its rapid progression and highlights the association between SARS-CoV-2 and the development of bronchiectasis, particularly in the setting of Panton-Valentine leukocidin\u2013positive\u00a0<em>S. aureus<\/em>\u00a0coinfection.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rapid-Onset Cystic Bronchiectasis in a Mechanically Ven [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[16,13],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21905"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21905"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21905\/revisions"}],"predecessor-version":[{"id":21906,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21905\/revisions\/21906"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}