{"id":21849,"date":"2022-09-03T05:46:00","date_gmt":"2022-09-02T21:46:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21849"},"modified":"2022-09-03T06:40:20","modified_gmt":"2022-09-02T22:40:20","slug":"bmj%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e9%95%bf%e6%9c%9f%e6%96%b0%e5%86%a0%e8%82%ba%e7%82%8e%e7%97%87%e7%8a%b6%e5%9c%a8%e6%8e%a5%e7%a7%8d%e7%96%ab%e8%8b%97%e5%90%8e%e7%9a%84%e5%8f%98","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21849","title":{"rendered":"[BMJ\u53d1\u8868\u8bba\u6587]\uff1a\u65b0\u51a0\u80ba\u708e\u957f\u671f\u540e\u9057\u75c7\u5728\u63a5\u79cd\u75ab\u82d7\u540e\u7684\u53d8\u5316"},"content":{"rendered":"\n

Research<\/strong><\/p>\n\n\n\n

Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study<\/h1>\n\n\n\n

Daniel Ayoubkhani<\/a>, Charlotte Bermingham, Koen B Pouwels, et al<\/h3>\n\n\n\n

BMJ<\/em> 2022; 377 doi: https:\/\/doi.org\/10.1136\/bmj-2021-069676<\/a> (Published 18 May 2022)Cite this as: BMJ<\/em> 2022;377:e069676<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Objective<\/strong> To estimate associations between covid-19 vaccination and long covid symptoms in adults with SARS-CoV-2 infection before vaccination.<\/p>\n\n\n\n

Design<\/strong> Observational cohort study.<\/p>\n\n\n\n

Setting<\/strong> Community dwelling population, UK.<\/p>\n\n\n\n

Participants<\/strong> 28\u2009356 participants in the Office for National Statistics COVID-19 Infection Survey aged 18-69 years who received at least one dose of an adenovirus vector or mRNA covid-19 vaccine after testing positive for SARS-CoV-2 infection.<\/p>\n\n\n\n

Main outcome measure<\/strong> Presence of long covid symptoms at least 12 weeks after infection over the follow-up period 3 February to 5 September 2021.<\/p>\n\n\n\n

Results<\/strong> Mean age of participants was 46 years, 55.6% (n=15\u2009760) were women, and 88.7% (n=25\u2009141) were of white ethnicity. Median follow-up was 141 days from first vaccination (among all participants) and 67 days from second vaccination (83.8% of participants). 6729 participants (23.7%) reported long covid symptoms of any severity at least once during follow-up. A first vaccine dose was associated with an initial 12.8% decrease (95% confidence interval \u221218.6% to \u22126.6%, P<0.001) in the odds of long covid, with subsequent data compatible with both increases and decreases in the trajectory (0.3% per week, 95% confidence interval \u22120.6% to 1.2% per week, P=0.51). A second dose was associated with an initial 8.8% decrease (95% confidence interval \u221214.1% to \u22123.1%, P=0.003) in the odds of long covid, with a subsequent decrease by 0.8% per week (\u22121.2% to \u22120.4% per week, P<0.001). Heterogeneity was not found in associations between vaccination and long covid by sociodemographic characteristics, health status, hospital admission with acute covid-19, vaccine type (adenovirus vector or mRNA), or duration from SARS-CoV-2 infection to vaccination.<\/p>\n\n\n\n

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Conclusions<\/strong> The likelihood of long covid symptoms was observed to decrease after covid-19 vaccination and evidence suggested sustained improvement after a second dose, at least over the median follow-up of 67 days. Vaccination may contribute to a reduction in the population health burden of long covid, although longer follow-up is needed.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research Trajectory of long covid symptoms after covid- […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21849"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21849"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21849\/revisions"}],"predecessor-version":[{"id":21936,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21849\/revisions\/21936"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}