{"id":21840,"date":"2022-07-17T05:07:00","date_gmt":"2022-07-16T21:07:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21840"},"modified":"2022-07-17T10:44:50","modified_gmt":"2022-07-17T02:44:50","slug":"intensive-care-medicine%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%af%94%e8%be%838%e5%a4%a9%e4%b8%8e15%e5%a4%a9%e6%8a%97%e7%94%9f%e7%b4%a0%e6%b2%bb%e7%96%97%e9%93%9c%e7%bb%bf%e5%81%87%e5%8d%95","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21840","title":{"rendered":"[Intensive Care Medicine\u53d1\u8868\u8bba\u6587]\uff1a\u6bd4\u8f838\u5929\u4e0e15\u5929\u6297\u751f\u7d20\u6cbb\u7597\u94dc\u7eff\u5047\u5355\u80de\u83cc\u547c\u5438\u673a\u76f8\u5173\u80ba\u708e\u6210\u5e74\u60a3\u8005"},"content":{"rendered":"\n<ul><li>Original <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00134-022-06690-5#article-info\">Published:\u00a0<time datetime=\"2022-05-13\">13 May 2022<\/time><\/a><\/li><\/ul>\n\n\n\n<h1 class=\"wp-block-heading\">Comparison of 8 versus 15&nbsp;days of antibiotic therapy for&nbsp;<em>Pseudomonas aeruginosa<\/em>&nbsp;ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial<\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">Adrien Bougl\u00e9,\u00a0Sophie Tuffet,\u00a0Laura Federici,\u00a0et al<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">Intensive Care Med 13 May 2022<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">https:\/\/doi.org\/10.1007\/s00134-022-06690-5<\/h3>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"Abs1\">Abstract<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Purpose<\/h3>\n\n\n\n<p>Compared to long duration of antibiotic therapy, a short duration has a comparable clinical efficacy for ventilator-associated pneumonia (VAP), with the exception of documented VAP of non-fermenting Gram-negative bacilli (NF-GNB), including&nbsp;<em>Pseudomonas aeruginosa<\/em>&nbsp;(PA). We aimed to assess the non-inferiority of a short duration of antibiotics (8&nbsp;days) vs. prolonged antibiotic therapy (15&nbsp;days) in VAP due to PA (PA-VAP).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Methods<\/h3>\n\n\n\n<p>We conducted a nationwide, randomized, open-labeled, multicenter, non-inferiority trial to evaluate optimal duration of antibiotic treatment in PA-VAP. Eligible patients were adults with diagnosis of PA-VAP and randomly assigned in 1:1 ratio to receive a short-duration treatment (8&nbsp;days) or a long-duration treatment (15&nbsp;days). A pre-specified analysis was used to assess a composite endpoint combining mortality and PA-VAP recurrence rate during hospitalization in the intensive care unit (ICU) within 90&nbsp;days.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Results<\/h3>\n\n\n\n<p>In intention-to-treat population (<em>n<\/em>\u2009=\u2009186), the percentage of patients who reached the composite endpoint was 25.5% (<em>N<\/em>\u2009=\u200925\/98) in the 15-day group versus 35.2% (<em>N<\/em>\u2009=\u200931\/88) in the 8-day group (difference 9.7%, 90% confidence interval (CI) 0.0\u201321.2%). The percentage of recurrence of PA-VAP during the ICU stay was 9.2% in the 15-day group versus 17% in the 8-day group. The two groups had similar median days of mechanical ventilation, of ICU stay, number of extra pulmonary infections and acquisition of multidrug-resistant (MDR) pathogens during ICU stay.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs00134-022-06690-5\/MediaObjects\/134_2022_6690_Fig1_HTML.png?as=webp\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs00134-022-06690-5\/MediaObjects\/134_2022_6690_Fig2_HTML.png?as=webp\" alt=\"\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Conclusions<\/h3>\n\n\n\n<p>Our study showed no differences in the composite or separate outcomes (90-day mortality or VAP recurrence) between short- and long-duration treatments for PA-VAP. However, the lack of power limits the interpretation of this study<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Original Published:\u00a013 May 2022 Comparison of 8 versus  [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21840"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21840"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21840\/revisions"}],"predecessor-version":[{"id":21841,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21840\/revisions\/21841"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}