{"id":21385,"date":"2022-05-18T05:42:00","date_gmt":"2022-05-17T21:42:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21385"},"modified":"2022-05-18T06:12:51","modified_gmt":"2022-05-17T22:12:51","slug":"chest%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%8d%b1%e9%87%8d%e7%97%85%e6%82%a3%e8%80%85%e4%be%b5%e8%a2%ad%e6%80%a7%e5%bf%b5%e7%8f%a0%e8%8f%8c%e6%84%9f%e6%9f%93%e7%9a%84%e5%8d%b1%e9%99%a9","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21385","title":{"rendered":"[Chest\u53d1\u8868\u8bba\u6587]\uff1a\u5371\u91cd\u75c5\u60a3\u8005\u4fb5\u88ad\u6027\u5ff5\u73e0\u83cc\u611f\u67d3\u7684\u5371\u9669\u56e0\u7d20\uff1a\u7cfb\u7edf\u56de\u987e\u4e0emeta\u5206\u6790"},"content":{"rendered":"\n

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 161, ISSUE 2<\/a>, P345-355, FEBRUARY 01, 2022<\/p>\n\n\n\n

Risk Factors for Invasive\u00a0Candida<\/em>\u00a0Infection in Critically Ill Patients: A Systematic Review and Meta-analysis<\/h1>\n\n\n\n

Daniel O. Thomas-R\u00fcddel, Peter Schlattmann, Mathias Pletz, et al<\/h3>\n\n\n\n

Chest 2022; 161: 345-355<\/h3>\n\n\n\n

Background<\/h3>\n\n\n\n

Current guidelines recommend empirical antifungal therapy in patients with sepsis with high risk of invasive Candida<\/em> infection. However, many different risk factors have been derived from multiple studies. These risk factors lack specificity, and broad application would render most ICU patients eligible for empirical antifungal therapy.<\/p>\n\n\n\n

Research Question<\/h3>\n\n\n\n

What risk factors for invasive Candida<\/em> infection can be identified by a systematic review and meta-analysis?<\/p>\n\n\n\n

Study Design and Methods<\/h3>\n\n\n\n

We searched PubMed, Web of Science, ScienceDirect, Biomed Central, and Cochrane and extracted the raw and adjusted OR for each risk factor associated with invasive Candida<\/em> infection. We calculated pooled ORs for risk factors present in more than one study.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

We included 34 studies in our meta-analysis resulting in the assessment of 29 possible risk factors. Risk factors for invasive Candida<\/em> infection included demographic factors, comorbid conditions, and medical interventions. Although demographic factors do not play a role for the development of invasive Candida<\/em> infection, comorbid conditions (eg, HIV, Candida<\/em>colonization) and medical interventions have a significant impact. The risk factors associated with the highest risk for invasive Candida<\/em> infection were broad-spectrum antibiotics (OR, 5.6; 95% CI, 3.6-8.8), blood transfusion (OR, 4.9; 95% CI, 1.5-16.3), Candida<\/em> colonization (OR, 4.7; 95% CI, 1.6-14.3), central venous catheter (OR, 4.7; 95% CI, 2.7-8.1), and total parenteral nutrition (OR, 4.6; 95% CI, 3.3-6.3). However, dependence between the various risk factors is probably high.<\/p>\n\n\n\n

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Interpretation<\/h3>\n\n\n\n

Our systematic review and meta-analysis identified patient- and treatment-related factors that were associated with the risk for the development of invasive Candida<\/em> infection in the ICU. Most of the factors identified were either related to medical interventions during intensive care or to comorbid conditions.<\/p>\n","protected":false},"excerpt":{"rendered":"

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 161, I […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21385"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21385"}],"version-history":[{"count":2,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21385\/revisions"}],"predecessor-version":[{"id":21823,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21385\/revisions\/21823"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21385"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21385"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21385"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}