{"id":21340,"date":"2022-03-06T05:14:00","date_gmt":"2022-03-05T21:14:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21340"},"modified":"2022-03-06T07:05:27","modified_gmt":"2022-03-05T23:05:27","slug":"nejm%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92mrna%e7%96%ab%e8%8b%97bnt162b2%e5%af%b9%e6%96%b0%e5%86%a0%e8%82%ba%e7%82%8e%e9%9d%92%e5%b0%91%e5%b9%b4%e5%8d%b1","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21340","title":{"rendered":"[NEJM\u53d1\u8868\u8bba\u6587]\uff1a\u65b0\u51a0\u75c5\u6bd2mRNA\u75ab\u82d7(BNT162b2)\u5bf9\u65b0\u51a0\u80ba\u708e\u9752\u5c11\u5e74\u5371\u91cd\u60a3\u8005\u7684\u6548\u679c"},"content":{"rendered":"\n

ORIGINAL ARTICLE<\/a><\/p>\n\n\n\n

Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents<\/h1>\n\n\n\n

Samantha M. Olson, Margaret M. Newhams, Natasha B. Halasa,\u00a0et al<\/h3>\n\n\n\n

N Engl J Med 2022; 386:713-723
DOI: 10.1056\/NEJMoa2117995<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

BACKGROUND<\/h2>\n\n\n\n

The increasing incidence of pediatric hospitalizations associated with coronavirus disease 2019 (Covid-19) caused by the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States has offered an opportunity to assess the real-world effectiveness of the BNT162b2 messenger RNA vaccine in adolescents between 12 and 18 years of age.<\/p>\n\n\n\n

METHODS<\/h2>\n\n\n\n

We used a case\u2013control, test-negative design to assess vaccine effectiveness against Covid-19 resulting in hospitalization, admission to an intensive care unit (ICU), the use of life-supporting interventions (mechanical ventilation, vasopressors, and extracorporeal membrane oxygenation), or death. Between July 1 and October 25, 2021, we screened admission logs for eligible case patients with laboratory-confirmed Covid-19 at 31 hospitals in 23 states. We estimated vaccine effectiveness by comparing the odds of antecedent full vaccination (two doses of BNT162b2) in case patients as compared with two hospital-based control groups: patients who had Covid-19\u2013like symptoms but negative results on testing for SARS-CoV-2 (test-negative) and patients who did not have Covid-19\u2013like symptoms (syndrome-negative).<\/a><\/p>\n\n\n\n

RESULTS<\/h2>\n\n\n\n

A total of 445 case patients and 777 controls were enrolled. Overall, 17 case patients (4%) and 282 controls (36%) had been fully vaccinated. Of the case patients, 180 (40%) were admitted to the ICU, and 127 (29%) required life support; only 2 patients in the ICU had been fully vaccinated. The overall effectiveness of the BNT162b2 vaccine against hospitalization for Covid-19 was 94% (95% confidence interval [CI], 90 to 96); the effectiveness was 95% (95% CI, 91 to 97) among test-negative controls and 94% (95% CI, 89 to 96) among syndrome-negative controls. The effectiveness was 98% against ICU admission and 98% against Covid-19 resulting in the receipt of life support. All 7 deaths occurred in patients who were unvaccinated.<\/p>\n\n\n\n

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CONCLUSIONS<\/h2>\n\n\n\n

Among hospitalized adolescent patients, two doses of the BNT162b2 vaccine were highly effective against Covid-19\u2013related hospitalization and ICU admission or the receipt of life support. (Funded by the Centers for Disease Control and Prevention.)<\/p>\n","protected":false},"excerpt":{"rendered":"

ORIGINAL ARTICLE Effectiveness of BNT162b2 Vaccine agai […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21340"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21340"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21340\/revisions"}],"predecessor-version":[{"id":21341,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21340\/revisions\/21341"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21340"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}