{"id":21338,"date":"2022-05-08T05:28:00","date_gmt":"2022-05-07T21:28:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21338"},"modified":"2022-05-08T06:15:15","modified_gmt":"2022-05-07T22:15:15","slug":"jama%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%96%b0%e5%86%a0%e8%82%ba%e7%82%8e%e6%82%a3%e8%80%85ards%e4%b8%8e%e8%bd%ac%e5%87%baicu%e5%90%8e%e6%82%a3%e8%80%85%e5%ae%b6%e5%b1%9e%e5%88%9b","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21338","title":{"rendered":"[JAMA\u53d1\u8868\u8bba\u6587]\uff1a\u65b0\u51a0\u80ba\u708e\u60a3\u8005ARDS\u4e0e\u8f6c\u51faICU\u540e\u60a3\u8005\u5bb6\u5c5e\u521b\u4f24\u540e\u5e94\u6fc0\u969c\u788d\u75c7\u72b6\u7684\u76f8\u5173\u6027"},"content":{"rendered":"\n

Original Investigation Caring for the Critically Ill PatientFebruary 18, 2022<\/p>\n\n\n\n

Association of COVID-19 Acute Respiratory Distress Syndrome With Symptoms of Posttraumatic Stress Disorder in Family Members After ICU Discharge<\/h1>\n\n\n\n

Elie\u00a0Azoulay,\u00a0Matthieu\u00a0Resche-Rigon,\u00a0Bruno\u00a0Megarbane, et al<\/h3>\n\n\n\n

JAMA.\u00a0<\/em>Published online February 18, 2022. doi:10.1001\/jama.2022.2017<\/h3>\n\n\n\n

Key Points<\/p>\n\n\n\n

Question<\/strong>  Is the risk of posttraumatic stress disorder (PTSD) symptoms in family members of intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS) due to COVID-19 different from that of family members of patients with non\u2013COVID-19 ARDS?<\/p>\n\n\n\n

Findings<\/strong>  In a prospective cohort study of 517 family members of ICU patients, PTSD-related symptoms at 90 days after ICU discharge were significantly more common in family members of patients with COVID-19 ARDS compared with non\u2013COVID-19 ARDS (35% vs 19%). In a multivariable analysis adjusting for age, sex, and level of social support, COVID-19 ARDS was independently associated with PTSD-related symptoms in family members (odds ratio, 2.05).<\/p>\n\n\n\n

Meaning<\/strong>  ARDS due to COVID-19 was associated with a greater risk-adjusted rate of PTSD symptoms among family members compared with ARDS from other causes.<\/a>Abstract<\/p>\n\n\n\n

Importance<\/strong>  Persistent physical and mental disorders are frequent in survivors of COVID-19\u2013related acute respiratory distress syndrome (ARDS). However, data on these disorders among family members are scarce.<\/p>\n\n\n\n

Objective<\/strong>  To determine the association between patient hospitalization for COVID-19 ARDS vs ARDS from other causes and the risk of posttraumatic stress disorder (PTSD)\u2013related symptoms in family members.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  Prospective cohort study in 23 intensive care units (ICUs) in France (January 2020 to June 2020 with final follow-up ending in October 2020). ARDS survivors and family members (1 family member per patient) were enrolled.<\/p>\n\n\n\n

Exposures<\/strong>  Family members of patients hospitalized for ARDS due to COVID-19 vs ARDS due to other causes.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was family member symptoms of PTSD at 90 days after ICU discharge, measured by the Impact of Events Scale-Revised (score range, 0 [best] to 88 [worst]; presence of PTSD symptoms defined by score >22). Secondary outcomes were family member symptoms of anxiety and depression at 90 days assessed by the Hospital Anxiety and Depression Scale (score range, 0 [best] to 42 [worst]; presence of anxiety or depression symptoms defined by subscale scores \u22657). Multivariable logistic regression models were used to determine the association between COVID-19 status and outcomes.<\/p>\n\n\n\n

Results<\/strong>  Among 602 family members and 307 patients prospectively enrolled, 517 (86%) family members (median [IQR] age, 51 [40-63] years; 72% women; 48% spouses; 26% bereaved because of the study patient\u2019s death; 303 [50%] family members of COVID-19 patients) and 273 (89%) patients (median [IQR] age, 61 [50-69] years; 34% women; 181 [59%] with COVID-19) completed the day-90 assessment. Compared with non\u2013COVID-19 ARDS, family members of patients with COVID-19 ARDS had a significantly higher prevalence of symptoms of PTSD (35% [103\/293] vs 19% [40\/211]; difference, 16% [95% CI, 8%-24%]; P<\/em>\u2009<\u2009.001), symptoms of anxiety (41% [121\/294] vs 34% [70\/207]; difference, 8% [95% CI, 0%-16%]; P<\/em>=\u2009.05), and symptoms of depression (31% [91\/291] vs 18% [37\/209]; difference, 13% [95% CI, 6%-21%]; P<\/em><\u2009.001). In multivariable models adjusting for age, sex, and level of social support, COVID-19 ARDS was significantly associated with increased risk of PTSD-related symptoms in family members (odds ratio, 2.05 [95% CI, 1.30 to 3.23]).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  Among family members of patients hospitalized in the ICU with ARDS, COVID-19 disease, as compared with other causes of ARDS, was significantly associated with increased risk of symptoms of PTSD at 90 days after ICU discharge.<\/p>\n\n\n\n

Trial Registration<\/strong>  ClinicalTrials.gov Identifier: NCT04341519<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation Caring for the Critically I […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21338"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21338"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21338\/revisions"}],"predecessor-version":[{"id":21339,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21338\/revisions\/21339"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}