{"id":21206,"date":"2022-02-14T05:22:00","date_gmt":"2022-02-13T21:22:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21206"},"modified":"2022-02-14T05:44:38","modified_gmt":"2022-02-13T21:44:38","slug":"nejm%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%9c%a8%e5%9d%a6%e6%a1%91%e5%b0%bc%e4%ba%9a%e5%b9%bc%e5%b9%b4%e4%bd%bf%e7%94%a8%e8%9a%8a%e5%b8%90%e4%b8%8e%e6%88%90%e5%b9%b4%e5%ad%98%e6%b4%bb","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21206","title":{"rendered":"[NEJM\u53d1\u8868\u8bba\u6587]\uff1a\u5728\u5766\u6851\u5c3c\u4e9a\u5e7c\u5e74\u4f7f\u7528\u868a\u5e10\u4e0e\u6210\u5e74\u5b58\u6d3b\u7387"},"content":{"rendered":"\n

ORIGINAL ARTICLE<\/a><\/p>\n\n\n\n

Mosquito Net Use in Early Childhood and Survival to Adulthood in Tanzania<\/h1>\n\n\n\n

G\u00fcnther Fink, Sigilbert Mrema, Salim Abdulla, et al<\/h3>\n\n\n\n

N Engl J Med 2022; 386:428-436
DOI: 10.1056\/NEJMoa2112524<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

BACKGROUND<\/h2>\n\n\n\n

It has been hypothesized that in high-transmission settings, malaria control in early childhood (<5 years of age) might delay the acquisition of functional immunity and shift child deaths from younger to older ages.<\/p>\n\n\n\n

METHODS<\/h2>\n\n\n\n

We used data from a 22-year prospective cohort study in rural southern Tanzania to estimate the association between early-life use of treated nets and survival to adulthood. All the children born between January 1, 1998, and August 30, 2000, in the study area were invited to enroll in a longitudinal study from 1998 through 2003. Adult survival outcomes were verified in 2019 through community outreach and mobile telephones. We used Cox proportional-hazards models to estimate the association between the use of treated nets in early childhood and survival to adulthood, adjusting for potential confounders.<\/a><\/p>\n\n\n\n

RESULTS<\/h2>\n\n\n\n

A total of 6706 children were enrolled. In 2019, we verified information on the vital status of 5983 participants (89%). According to reports of early-life community outreach visits, approximately one quarter of children never slept under a treated net, one half slept under a treated net some of the time, and the remaining quarter always slept under a treated net. Participants who were reported to have used treated nets at half the early-life visits or more had a hazard ratio for death of 0.57 (95% confidence interval [CI], 0.45 to 0.72) as compared with those who were reported to have used treated nets at less than half the visits. The corresponding hazard ratio between 5 years of age and adulthood was 0.93 (95% CI, 0.58 to 1.49).<\/p>\n\n\n\n

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CONCLUSIONS<\/h2>\n\n\n\n

In this long-term study of early-life malaria control in a high-transmission setting, the survival benefit from early-life use of treated nets persisted to adulthood. (Funded by the Eckenstein-Geigy Professorship and others.)<\/p>\n","protected":false},"excerpt":{"rendered":"

ORIGINAL ARTICLE Mosquito Net Use in Early Childhood an […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21206"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21206"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21206\/revisions"}],"predecessor-version":[{"id":21207,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21206\/revisions\/21207"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21206"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21206"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}