{"id":21171,"date":"2022-02-10T05:20:00","date_gmt":"2022-02-09T21:20:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=21171"},"modified":"2022-02-10T05:54:31","modified_gmt":"2022-02-09T21:54:31","slug":"jama%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e4%bb%a5%e8%89%b2%e5%88%97%e5%8c%bb%e5%8a%a1%e4%ba%ba%e5%91%98%e6%8e%a5%e7%a7%8d%e7%ac%ac%e4%b8%89%e9%92%88%e6%96%b0%e5%86%a0%e7%97%85mrna%e7%96%ab","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=21171","title":{"rendered":"[JAMA\u53d1\u8868\u8bba\u6587]\uff1a\u4ee5\u8272\u5217\u533b\u52a1\u4eba\u5458\u63a5\u79cd\u7b2c\u4e09\u9488\u65b0\u51a0\u75c5mRNA\u75ab\u82d7\u4e0e\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u7684\u76f8\u5173\u6027"},"content":{"rendered":"\n

Original Investigation January 10, 2022<\/p>\n\n\n\n

Association of a Third Dose of BNT162b2 Vaccine With Incidence of SARS-CoV-2 Infection Among Health Care Workers in Israel<\/h1>\n\n\n\n

Avishay\u00a0Spitzer,\u00a0Yoel\u00a0Angel,\u00a0Or\u00a0Marudi,\u00a0et al<\/h3>\n\n\n\n

JAMA.\u00a0<\/em>2022;327(4):341-349. doi:10.1001\/jama.2021.23641<\/h3>\n\n\n\n

Key Points<\/p>\n\n\n\n

Question<\/strong>  What is the association between immunization with a third (booster) dose of BNT162b2 vaccine (Pfizer-BioNTech) and the incidence of SARS-CoV-2 infection among immunocompetent health care workers?<\/p>\n\n\n\n

Findings<\/strong>  In this cohort study of 1928 health care workers in Israel who were previously vaccinated with a 2-dose series of BNT162b2, administration of a booster dose compared with not receiving one was significantly associated with lower risk of SARS-CoV-2 infection during a median of 39 days of follow-up (adjusted hazard ratio, 0.07).<\/p>\n\n\n\n

Meaning<\/strong>  Among health care workers previously vaccinated with a 2-dose series of BNT162b2, administration of a booster dose compared with not receiving one was significantly associated with a lower rate of SARS-CoV-2 infection in short-term follow-up.<\/a>Abstract<\/p>\n\n\n\n

Importance<\/strong>  Administration of a BNT162b2 booster dose (Pfizer-BioNTech) to fully vaccinated individuals aged 60 years and older was significantly associated with lower risk of SARS-CoV-2 infection and severe illness. Data are lacking on the effectiveness of booster doses for younger individuals and health care workers.<\/p>\n\n\n\n

Objective<\/strong>  To estimate the association of a BNT162b2 booster dose with SARS-CoV-2 infections among health care workers who were previously vaccinated with a 2-dose series of BNT162b2.<\/p>\n\n\n\n

Design, Setting, and Participants<\/strong>  This was a prospective cohort study conducted at a tertiary medical center in Tel Aviv, Israel. The study cohort included 1928 immunocompetent health care workers who were previously vaccinated with a 2-dose series of BNT162b2, and had enrolled between August 8 and 19, 2021, with final follow-up reported through September 20, 2021. Screening for SARS-CoV-2 infection was performed every 14 days. Anti\u2013spike protein receptor binding domain IgG titers were determined at baseline and 1 month after enrollment. Cox regression with time-dependent analysis was used to estimate hazard ratios of SARS-CoV-2 infection between booster-immunized status and 2-dose vaccinated (booster-nonimmunized) status.<\/p>\n\n\n\n

Exposures<\/strong>  Vaccination with a booster dose of BNT162b2 vaccine.<\/p>\n\n\n\n

Main Outcomes and Measures<\/strong>  The primary outcome was SARS-CoV-2 infection, as confirmed by reverse transcriptase\u2013polymerase chain reaction.<\/p>\n\n\n\n

Results<\/strong>  Among 1928 participants, the median age was 44 years (IQR, 36-52 years) and 1381 were women (71.6%). Participants completed the 2-dose vaccination series a median of 210 days (IQR, 205-213 days) before study enrollment. A total of 1650 participants (85.6%) received the booster dose. During a median follow-up of 39 days (IQR, 35-41 days), SARS-CoV-2 infection occurred in 44 participants (incidence rate, 60.2 per 100\u202f000 person-days); 31 (70.5%) were symptomatic. Five SARS-CoV-2 infections occurred in booster-immunized participants and 39 in booster-nonimmunized participants (incidence rate, 12.8 vs 116 per 100\u202f000 person-days, respectively). In a time-dependent Cox regression analysis, the adjusted hazard ratio of SARS-CoV-2 infection for booster-immunized vs booster-nonimmunized participants was 0.07 (95% CI, 0.02-0.20).<\/p>\n\n\n\n

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Conclusions and Relevance<\/strong>  Among health care workers at a single center in Israel who were previously vaccinated with a 2-dose series of BNT162b2, administration of a booster dose compared with not receiving one was associated with a significantly lower rate of SARS-CoV-2 infection over a median of 39 days of follow-up. Ongoing surveillance is required to assess durability of the findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

Original Investigation January 10, 2022 Associatio […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21171"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=21171"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21171\/revisions"}],"predecessor-version":[{"id":21172,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/21171\/revisions\/21172"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=21171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=21171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=21171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}