{"id":20957,"date":"2021-12-25T04:39:00","date_gmt":"2021-12-24T20:39:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=20957"},"modified":"2021-12-25T05:45:00","modified_gmt":"2021-12-24T21:45:00","slug":"bmj%e5%9c%a3%e8%af%9e%e4%b8%93%e5%88%8a%ef%bc%9a%e9%a3%9f%e6%8c%87%e4%b8%8e%e7%8e%af%e6%8c%87%e9%95%bf%e5%ba%a6%e6%af%94%e5%80%bc%e6%98%af%e5%90%a6%e4%b8%ba%e5%b9%b8%e8%bf%90%e7%9a%84%e7%94%9f","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=20957","title":{"rendered":"[BMJ\u5723\u8bde\u4e13\u520a]\uff1a\u98df\u6307\u4e0e\u73af\u6307\u957f\u5ea6\u6bd4\u503c\u662f\u5426\u4e3a\u5e78\u8fd0\u7684\u751f\u7269\u6807\u5fd7\u7269\uff1f"},"content":{"rendered":"\n

Research<\/strong> Christmas 2021: Get Lucky<\/p>\n\n\n\n

Giving science the finger\u2014is the second-to-fourth digit ratio (2D:4D) a biomarker of good luck? A cross sectional study<\/h1>\n\n\n\n

James M Smoliga<\/a>,\u00a0Lucas K Fogaca, Jessica S Siplon, et al<\/h3>\n\n\n\n

BMJ<\/em>\u00a02021;\u00a0375\u00a0doi:\u00a0https:\/\/doi.org\/10.1136\/bmj-2021-067849<\/a>\u00a0(Published 15 December 2021)Cite this as:\u00a0BMJ<\/em>\u00a02021;375:e067849<\/h3>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Objectives<\/strong> To explore whether random chance, weak research methodology, or inappropriate reporting can lead to claims of statistically significant (yet, biologically meaningless) biomarker associations, using as a model the relation between a common surrogate of prenatal testosterone exposure, second-to-fourth digit ratio (2D:4D), and a random indicator of good luck.<\/p>\n\n\n\n

Design<\/strong> Cross sectional study.<\/p>\n\n\n\n

Setting<\/strong> University sports performance laboratory in the United States. Data were collected from May 2015 to February 2017.<\/p>\n\n\n\n

Participants<\/strong> 176 adults (74 women, 102 men), including university students, faculty, and staff with no history of injuries, disease, or medical conditions that would affect digit length.<\/p>\n\n\n\n

Main outcome measures<\/strong> 2D:4D, body composition parameters potentially influenced by androgens (bone mineral content, bone mineral density, body fat percentage), and good luck (using poker hands from randomly selected playing cards as a surrogate).<\/p>\n\n\n\n

Results<\/strong> 2D:4D significantly correlated with select body composition parameters (Spearman\u2019s r<\/em>s<\/sub> range \u22120.26 to 0.23; P<0.05), but the correlations varied by sex, participant hand measured, and the method of measuring 2D:4D (by photocopy or radiography). However, the strongest correlation observed was between right hand 2D:4D in men measured by radiograph and poker hand rank (r<\/em>s<\/sub>=0.28, P=0.004).<\/p>\n\n\n\n

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Conclusions<\/strong> Greater prenatal exposure to testosterone, as estimated by a lower 2D:4D, significantly increases good luck in adulthood, and also modulates body composition (albeit to a lesser degree). While these findings are consistent with a wealth of research reporting that 2D:4D is related to many seemingly disparate outcomes, they are not meant to provide confirmatory evidence that 2D:4D is a universal biomarker of nearly everything. Instead, the associations between 2D:4D and good luck are simply due to chance, and provide a \u201chandy\u201d example of the reproducibility crisis within medical and scientific research. Biologically sound hypotheses, pre-registration of trials, strong methodological and statistical analyses, transparent reporting of negative results, and unbiased interpretation of data are all necessary for biomarker studies and other areas of clinical research.<\/p>\n","protected":false},"excerpt":{"rendered":"

Research Christmas 2021: Get Lucky Giving science […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/20957"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20957"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/20957\/revisions"}],"predecessor-version":[{"id":20958,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/20957\/revisions\/20958"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}