{"id":20763,"date":"2021-12-27T05:03:00","date_gmt":"2021-12-26T21:03:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=20763"},"modified":"2021-12-27T05:45:08","modified_gmt":"2021-12-26T21:45:08","slug":"bmj%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e6%8e%a5%e7%a7%8d%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92mrna%e7%96%ab%e8%8b%97%e5%90%8e%e6%97%b6%e9%97%b4%e4%b8%8e%e6%96%b0%e5%86%a0%e7%97%85%e6%af%92","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=20763","title":{"rendered":"[BMJ\u53d1\u8868\u8bba\u6587]\uff1a\u63a5\u79cd\u65b0\u51a0\u75c5\u6bd2mRNA\u75ab\u82d7\u540e\u65f6\u95f4\u4e0e\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u98ce\u9669"},"content":{"rendered":"\n<p><strong>Research<\/strong><\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"page-title\">Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection: test negative design study<\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">Ariel Israel<a rel=\"noreferrer noopener\" href=\"https:\/\/orcid.org\/0000-0003-4389-8896\" target=\"_blank\"><\/a>, Eugene Merzon<a rel=\"noreferrer noopener\" href=\"https:\/\/orcid.org\/0000-0001-5469-0236\" target=\"_blank\"><\/a>, Alejandro A Sch\u00e4ffer, et al<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><em>BMJ<\/em>\u00a02021;\u00a0375\u00a0doi:\u00a0<a href=\"https:\/\/doi.org\/10.1136\/bmj-2021-067873\">https:\/\/doi.org\/10.1136\/bmj-2021-067873<\/a>\u00a0(Published 25 November 2021)Cite this as:\u00a0<em>BMJ<\/em>\u00a02021;375:e067873<\/h3>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p id=\"p-2\"><strong>Objectives<\/strong>&nbsp;To determine whether time elapsed since the second injection of the Pfizer-BioNTech BNT162b2 mRNA vaccine was significantly associated with the risk of covid-19 infection after vaccination in people who received two vaccine injections.<\/p>\n\n\n\n<p id=\"p-3\"><strong>Design<\/strong>&nbsp;Test negative design study.<\/p>\n\n\n\n<p id=\"p-4\"><strong>Setting<\/strong>&nbsp;Electronic health records of a large state mandated healthcare organisation, Israel.<\/p>\n\n\n\n<p id=\"p-5\"><strong>Participants<\/strong>&nbsp;Adults aged \u226518 years who had received a reverse transcription polymerase chain reaction (RT-PCR) test between 15 May 2021 and 17 September 2021, at least three weeks after their second vaccine injection, had not received a third vaccine injection, and had no history of covid-19 infection.<\/p>\n\n\n\n<p id=\"p-6\"><strong>Main outcome measures<\/strong>&nbsp;Positive result for the RT-PCR test. Individuals who tested positive for SARS-CoV-2 and controls were matched for week of testing, age category, and demographic group (ultra-orthodox Jews, individuals of Arab ancestry, and the general population). Conditional logistic regression was adjusted for age, sex, socioeconomic status, and comorbid conditions.<\/p>\n\n\n\n<p id=\"p-7\"><strong>Results<\/strong>&nbsp;83\u2009057 adults received an RT-PCR test for SARS-CoV-2 during the study period and 9.6% had a positive result. Time elapsed since the vaccine injection was significantly longer in individuals who tested positive (P&lt;0.001). Adjusted odds ratio for infection at time intervals &gt;90 days since vaccination were significantly increased compared with the reference of &lt;90 days: 2.37 (95% confidence interval 1.67 to 3.36) for 90-119 days, 2.66 (1.94 to 3.66) for 120-149 days, 2.82 (2.07 to 3.84) for 150-179 days, and 2.82 (2.07 to 3.85) for \u2265180 days (P&lt;0.001 for each 30 day interval).<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.bmj.com\/content\/bmj\/375\/bmj-2021-067873\/F1.large.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.bmj.com\/content\/bmj\/375\/bmj-2021-067873\/F2.large.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<p id=\"p-8\"><strong>Conclusions<\/strong>&nbsp;In this large population of adults tested for SARS-CoV-2 by RT-PCR after two doses of mRNA BNT162b2 vaccine, a gradual increase in the risk of infection was seen for individuals who received their second vaccine dose after at least 90 days.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Elapsed time since BNT162b2 vaccine and risk o [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/20763"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20763"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/20763\/revisions"}],"predecessor-version":[{"id":20764,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/20763\/revisions\/20764"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20763"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20763"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20763"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}