{"id":20604,"date":"2021-11-23T04:55:00","date_gmt":"2021-11-22T20:55:00","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=20604"},"modified":"2021-11-23T05:51:57","modified_gmt":"2021-11-22T21:51:57","slug":"intensive-care-med%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e5%a4%a7%e5%89%82%e9%87%8fcpfa%e6%b2%bb%e7%96%97%e6%84%9f%e6%9f%93%e6%80%a7%e4%bc%91%e5%85%8b","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=20604","title":{"rendered":"[Intensive Care Med\u53d1\u8868\u8bba\u6587]\uff1a\u5927\u5242\u91cfCPFA\u6cbb\u7597\u611f\u67d3\u6027\u4f11\u514b"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial<\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">Elena Garbero,\u00a0Sergio Livigni,\u00a0Fiorenza Ferrari, et al<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">Intensive Care Med <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00134-021-06501-3#article-info\">Published:\u00a0<time datetime=\"2021-10-03\">03 October 2021<\/time><\/a><\/h3>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"Abs1\">Abstract<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Purpose<\/h3>\n\n\n\n<p>This study aimed at evaluating the efficacy and safety of high-dose (&gt;\u20090.2 L\/kg of treated plasma per day) coupled plasma filtration-adsorption (CPFA) in treating patients with septic shock.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Methods<\/h3>\n\n\n\n<p>Multicentre, randomised, adaptive trial, performed in 12 Italian intensive care units (ICUs). Patients aged 14 or more, admitted to the ICU with septic shock, or had developed it during the stay were eligible. The final outcome was mortality at discharge from the last hospital at which the patient received care.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Results<\/h3>\n\n\n\n<p>Between May 2015, and October 2017, 115 patients were randomised. The first interim analysis revealed a number of early deaths, prompting an unplanned analysis. Last hospital mortality was non-significantly higher in the CPFA (55.6%) than in the control group (46.2%,&nbsp;<em>p<\/em>\u2009=\u20090.35). The 90-day survival curves diverged in favour of the controls early after randomisation and remained separated afterwards (<em>p<\/em>\u2009=\u20090.100). An unplanned analysis showed higher mortality in CPFA compared to controls among patients without severe renal failure (<em>p<\/em>\u2009=\u20090.025); a dose\u2013response relationship was observed between treated plasma volume and mortality (<em>p<\/em>\u2009=\u20090.010).<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs00134-021-06501-3\/MediaObjects\/134_2021_6501_Fig1_HTML.png?as=webp\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs00134-021-06501-3\/MediaObjects\/134_2021_6501_Fig2_HTML.png?as=webp\" alt=\"\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs00134-021-06501-3\/MediaObjects\/134_2021_6501_Fig3_HTML.png?as=webp\" alt=\"\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Conclusion<\/h3>\n\n\n\n<p>The COMPACT-2 trial was stopped due to the possible harmful effect of CPFA in patients with septic shock. The harmful effect, if present, was particularly marked in the early phase of septic shock. Patients not requiring renal replacement therapy seemed most exposed to the possible harm, with evidence of a dose\u2013response effect. Until the mechanisms behind these results are fully understood, the use of CPFA for the treatment of patients with septic shock is not recommended.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>High dose coupled plasma filtration and adsorption in s [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[32,23],"tags":[],"_links":{"self":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/20604"}],"collection":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20604"}],"version-history":[{"count":1,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/20604\/revisions"}],"predecessor-version":[{"id":20605,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/20604\/revisions\/20605"}],"wp:attachment":[{"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20604"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20604"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csccm.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}