{"id":19255,"date":"2020-09-22T05:49:28","date_gmt":"2020-09-21T21:49:28","guid":{"rendered":"http:\/\/csccm.org.cn\/?p=19255"},"modified":"2020-09-26T07:27:36","modified_gmt":"2020-09-25T23:27:36","slug":"lancet-infect-dis%e5%8f%91%e8%a1%a8%e8%ae%ba%e6%96%87%ef%bc%9a%e4%b8%ad%e5%9b%bd%e6%ad%a6%e6%b1%8981%e5%90%8d%e6%96%b0%e5%86%a0%e8%82%ba%e7%82%8e%e6%82%a3%e8%80%85%e7%9a%84%e5%bd%b1%e5%83%8f","status":"publish","type":"post","link":"https:\/\/csccm.org.cn\/?p=19255","title":{"rendered":"[Lancet Infect Dis\u53d1\u8868\u8bba\u6587]\uff1a\u4e2d\u56fd\u6b66\u6c4981\u540d\u65b0\u51a0\u80ba\u708e\u60a3\u8005\u7684\u5f71\u50cf\u5b66\u8868\u73b0\uff1a\u63cf\u8ff0\u6027\u7814\u7a76"},"content":{"rendered":"\n

ARTICLES|\u00a0VOLUME 20, ISSUE 4<\/a>,\u00a0P425-434,\u00a0APRIL 01, 2020<\/p>\n\n\n\n

Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study<\/h1>\n\n\n\n

Heshui Shi, Xiaoyu Han, Nanchuan Jiang, et al<\/h3>\n\n\n\n

Lancet Infect Dis 2020; 20: 425-434<\/h3>\n\n\n\n

Summary \u6458\u8981<\/h2>\n\n\n\n

Background \u80cc\u666f<\/h3>\n\n\n\n

A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were successively reported in Wuhan, China. We aimed to describe the CT findings across different timepoints throughout the disease course.<\/p>\n\n\n\n

\u4e2d\u56fd\u6b66\u6c49\u8fde\u7eed\u62a5\u544a\u4e86\u4e00\u7ec4\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u5bfc\u81f4\u7684\u80ba\u708e(COVID-19)\u60a3\u8005\u3002\u6211\u4eec\u65e8\u5728\u63cf\u8ff0\u75c5\u7a0b\u4e2d\u4e0d\u540c\u65f6\u95f4\u70b9CT\u5f71\u50cf\u5b66\u8868\u73b0\u3002<\/p>\n\n\n\n

Methods \u65b9\u6cd5<\/h3>\n\n\n\n

Patients with COVID-19 pneumonia (confirmed by next-generation sequencing or RT-PCR) who were admitted to one of two hospitals in Wuhan and who underwent serial chest CT scans were retrospectively enrolled. Patients were grouped on the basis of the interval between symptom onset and the first CT scan: group 1 (subclinical patients; scans done before symptom onset), group 2 (scans done \u22641 week after symptom onset), group 3 (>1 week to 2 weeks), and group 4 (>2 weeks to 3 weeks). Imaging features and their distribution were analysed and compared across the four groups.<\/p>\n\n\n\n

\u56de\u987e\u6027\u7eb3\u5165\u6b66\u6c492\u5bb6\u533b\u9662\u6536\u6cbb\u7684\u63a5\u53d7\u7cfb\u5217\u80f8\u90e8CT\u626b\u63cf\u7684COVID-19\u80ba\u708e\u60a3\u8005\uff08\u6839\u636e\u4e8c\u4ee3\u6d4b\u5e8f\u6216RT-PCR\u786e\u8bca\uff09\u3002\u6839\u636e\u53d1\u75c5\u8ddd\u9996\u6b21CT\u626b\u63cf\u7684\u65f6\u95f4\u95f4\u9694\uff0c\u5c06\u60a3\u8005\u5206\u7ec4\uff1a1\u7ec4\uff08\u4e9a\u4e34\u5e8a\u60a3\u8005\uff1b\u53d1\u75c5\u524d\u8fdb\u884c\u626b\u63cf\uff09\uff0c2\u7ec4\uff08\u626b\u63cf\u8ddd\u53d1\u75c51\u5468\u5185\uff09\uff0c3\u7ec4\uff081-2\u5468\u4e4b\u95f4\uff09\uff0c4\u7ec4\uff082-3\u5468\u4e4b\u95f4\uff09\u3002\u5206\u6790\u5f71\u50cf\u5b66\u7279\u5f81\u53ca\u5206\u5e03\uff0c\u5e76\u8fdb\u884c\u7ec4\u95f4\u6bd4\u8f83\u3002<\/p>\n\n\n\n

Findings \u7ed3\u679c<\/h3>\n\n\n\n

81 patients admitted to hospital between Dec 20, 2019, and Jan 23, 2020, were retrospectively enrolled. The cohort included 42 (52%) men and 39 (48%) women, and the mean age was 49\u00b75 years (SD 11\u00b70). The mean number of involved lung segments was 10\u00b75 (SD 6\u00b74) overall, 2\u00b78 (3\u00b73) in group 1, 11\u00b71 (5\u00b74) in group 2, 13\u00b70 (5\u00b77) in group 3, and 12\u00b71 (5\u00b79) in group 4. The predominant pattern of abnormality observed was bilateral (64 [79%] patients), peripheral (44 [54%]), ill-defined (66 [81%]), and ground-glass opacification (53 [65%]), mainly involving the right lower lobes (225 [27%] of 849 affected segments). In group 1 (n=15), the predominant pattern was unilateral (nine [60%]) and multifocal (eight [53%]) ground-glass opacities (14 [93%]). Lesions quickly evolved to bilateral (19 [90%]), diffuse (11 [52%]) ground-glass opacity predominance (17 [81%]) in group 2 (n=21). Thereafter, the prevalence of ground-glass opacities continued to decrease (17 [57%] of 30 patients in group 3, and five [33%] of 15 in group 4), and consolidation and mixed patterns became more frequent (12 [40%] in group 3, eight [53%] in group 4).<\/p>\n\n\n\n

2019\u5e7412\u670820\u65e5\u81f32020\u5e741\u670823\u65e5\u95f4\uff0c\u5171\u670981\u540d\u60a3\u8005\u5165\u9662\u6cbb\u7597\u3002\u5176\u4e2d\u7537\u602742\u540d(52%)\uff0c\u5973\u602739\u540d (48%)\uff0c\u5e73\u5747\u5e74\u9f84 49\u00b75 \u5c81 (SD 11\u00b70)\u3002\u5e73\u5747\u53d7\u7d2f\u80ba\u6bb5\u6570\u4e3a 10\u00b75 (SD 6\u00b74)\uff0c1\u7ec4 2\u00b78 (3\u00b73)\uff0c2\u7ec4 11\u00b71 (5\u00b74)\uff0c3\u7ec4 13\u00b70 (5\u00b77)\uff0c4\u7ec4 12\u00b71 (5\u00b79)\u3002\u89c2\u5bdf\u5230\u7684\u5f71\u50cf\u5b66\u5f02\u5e38\u4e3b\u8981\u5305\u62ec\u53cc\u4fa7 (64\u540d [79%] \u60a3\u8005)\uff0c\u5916\u5468 (44 [54%])\uff0c\u8fb9\u754c\u4e0d\u6e05 (66 [81%])\u53ca\u78e8\u73bb\u7483\u5f71 (53 [65%])\uff0c\u4e3b\u8981\u7d2f\u53ca\u53f3\u4e0b\u53f6 (849\u4e2a\u53d7\u7d2f\u80ba\u6bb5\u7684225\u4e2a [27%])\u30021\u7ec4 (n=15) \u60a3\u8005\u4e2d\uff0c\u4e3b\u8981\u5f02\u5e38\u4e3a\u5355\u4fa7 (9 [60%]) \u53ca\u591a\u53f6 (8 [53%]) \u78e8\u73bb\u7483\u5f71 (14 [93%])\u30022\u7ec4 (n=21) \u60a3\u8005\u75c5\u53d8\u8fc5\u901f\u8fdb\u5c55\u4e3a\u53cc\u4fa7 (19 [90%])\uff0c\u5f25\u6f2b\u6027 (11 [52%])\uff0c\u78e8\u73bb\u7483\u75c5\u53d8 (17 [81%])\u3002\u6b64\u540e\uff0c\u78e8\u73bb\u7483\u5f71\u6bd4\u4f8b\u9010\u6e10\u964d\u4f4e (3\u7ec430\u540d\u60a3\u8005\u4e2d17\u540d [57%]\uff0c4\u7ec415\u540d\u60a3\u8005\u4e2d5\u540d [33%])\uff0c\u5b9e\u53d8\u548c\u6df7\u5408\u8868\u73b0\u9010\u6e10\u589e\u52a0 (3\u7ec4\u4e2d12\u540d [40%] \u60a3\u8005\uff0c4\u7ec4\u4e2d8\u540d [53%] \u60a3\u8005)\u3002<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n
\"\"\/<\/figure>\n\n\n\n

Interpretation \u7ed3\u8bba<\/h3>\n\n\n\n

COVID-19 pneumonia manifests with chest CT imaging abnormalities, even in asymptomatic patients, with rapid evolution from focal unilateral to diffuse bilateral ground-glass opacities that progressed to or co-existed with consolidations within 1\u20133 weeks. Combining assessment of imaging features with clinical and laboratory findings could facilitate early diagnosis of COVID-19 pneumonia.<\/p>\n\n\n\n

COVID-19\u80ba\u708e\u8868\u73b0\u4e3a\u80f8\u90e8CT\u5f71\u50cf\u5f02\u5e38\uff0c\u5373\u4f7f\u5728\u65e0\u75c7\u72b6\u60a3\u8005\u4e5f\u662f\u5982\u6b64\uff0c\u4e14\u57281-3\u5468\u5185\u4ece\u5c40\u7076\u6027\u5355\u4fa7\u78e8\u73bb\u7483\u5f71\u8fc5\u901f\u8fdb\u5c55\u4e3a\u5f25\u6f2b\u6027\u53cc\u4fa7\u819c\u73bb\u7483\u5f71\uff0c\u8fdb\u800c\u53d1\u5c55\u4e3a\u6216\u5408\u5e76\u5b9e\u53d8\u3002\u4e34\u5e8a\u548c\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u8054\u5408\u5f71\u50cf\u5b66\u8868\u73b0\u6709\u52a9\u4e8e\u65e9\u671f\u8bca\u65adCOVID-19\u80ba\u708e\u3002<\/p>\n\n\n\n

Funding<\/h3>\n\n\n\n

None.<\/p>\n","protected":false},"excerpt":{"rendered":"

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